Depress capsules


  • Active Ingredient: Hydrochlorothiazide
  • 25 mg, 12.5 mg
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What is Depress?

The active ingredient of Depress brand is hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Hydrochloro­thiazide USP is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet for oral administration contains 25 mg or 50 mg Hydrochlorothiazide USP. In addition, each tablet contains the following inactive ingredients: dibasic calcium phosphate, lactose monohydrate, pregelatinized starch, FD&C yellow No.6 lake, corn starch, colloidal silicon dioxide, and magnesium stearate.

Used for

Depress is used to treat diseases such as: Diabetes Insipidus, Edema, High Blood Pressure, Nephrocalcinosis, Osteoporosis.

Side Effect

Possible side effects of Depress include: greatly decreased frequency of urination or amount of urine; decrease in urine output or decrease in urine-concentrating ability; general feeling of tiredness or weakness; pinpoint red spots on the skin; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; loss of appetite; redness, soreness, or itching skin.

How to Buy Depress tablets online?

To get Depress online - just click on the "Buy Now" button in the top and follow along with our shop. Order and payment takes a few minutes, and all steps are obvious. We don't require a medical prescription plus also we have many methods of payment. Considering each detail of rapid delivery and confidentiality, you may read on the relevant pages on the links in the top menu.

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Have you lost weight on Depress?

If you’ve lost weight with Depress, feel free to leave a comment below sharing the amount of weight that you lost. To help others get a better understanding of your situation, provide details such as: the dose that you used; how quickly you noticed weight loss; the amount of time it took for your weight loss to peak; and whether you used other substances (medications, supplements, etc.) with Depress.

In your experience, was most of the weight that you lost purely water? Or was some of the weight that you lost also fat (due to appetite suppression and a calorie deficit)? Overall, was the loss of water weight from Depress considered favorable (such that it helped improve edema or your blood pressure) – or unfavorable (such that it wasn’t the primary aim of treatment).

What was the medical condition for which you were prescribed Depress? Do you believe that concomitant substance use might’ve influenced (enhanced or counteracted) the amount of weight loss that resulted from Depress? If you’re a long-term Depress user – how has your weight changed over time while using the medication?

I have stage 3 kidney failure due to years of untreated high blood pressure and over use of ibuprophen. I take atenolol, lisinopril, Depress, amlodipine, lipitor and synthroid. I want to know if Depress, lisinopril and lipitor are good or bad for kidney function?

Depress side effects

Get emergency medical help if you have signs of an allergic reaction to Depress: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

eye pain, vision problems;

jaundice (yellowing of the skin or eyes);

pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);

shortness of breath, wheezing, cough with foamy mucus, chest pain;

signs of electrolyte imbalance--dry mouth, thirst, drowsiness, lack of energy, restlessness, muscle pain or weakness, fast heart rate, nausea and vomiting, little or no urine; or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Depress side effects may include:

nausea, vomiting, loss of appetite;

muscle spasm; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Q: What are the benefits of combining Depress with benazepril?

A: Benazepril is a medication that is used to treat high blood pressure, congestive heart failure, and chronic renal failure. It is in the class of medications called ACE inhibitors that work by causing blood vessels to relax. This action then allows for easier blood flow and a decrease in blood pressure. Depress or HCTZ is a thiazide diuretic (water pill) used to treat fluid retention or high blood pressure. It works by increasing the amount of salt and water the kidneys eliminate from the bloodstream and body. By increasing the amount of water removed from the blood, this decreases blood volume, helping to achieve a lowering of your blood pressure. Using the two medications together, you are tackling blood pressure issues in two different ways, which increases the ability of lowering your blood pressure numbers, more than by using one medication alone. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. The optimal combination drug therapy for high blood pressure has not been established, although current guidelines recommend inclusion of a diuretic, like HCTZ. Lori Poulin, PharmD

Rated Depress (Microzide) for Hypertension Report

Horrible medication. I have all the symptoms everyone else stated including the nausea, GI distress, dizziness and overheating. Also since taking the pill for less than two weeks, the scale has gone up 6 lbs which is ridiculous. I indulged over Christmas and gained a couple pounds but I am now back to normal eating and exercising so this awful drug is the only reason.

Metabolic changes

Research by Price et al. (2013) suggests that the use of Depress could induce deleterious metabolic changes. Specifically, Price et al. discovered that Depress treatment significantly increased hepatic triglycerides (by approximately

57%) and simultaneously reduced insulin sensitivity.

Although having high triglycerides might not directly cause weight gain, reduced insulin sensitivity could certainly lead to weight gain and/or increased body fat. When insulin sensitivity decreases, this affects hormone signaling (e.g. leptin, ghrelin, etc.) to the brain, which can trigger an exaggerated appetite.

Furthermore, decreased insulin sensitivity may increase estrogen concentrations, an established risk factor for obesity. The combination of increased appetite and elevated estrogen could lead to overconsumption of calories, fat gain, and/or muscle loss. Some speculate that Depress may increase visceral and subcutaneous body fat when administered over a long-term.

Which drugs or supplements interact with Depress?

  • Depress reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of Depress. Blood sugar levels can be elevated by Depress, necessitating adjustment in the doses of medications that are used for treating diabetes.
  • Combining Depress with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium (hypokalemia) can increase the toxicity of digoxin (Lanoxin).
  • Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to Depress and reduce its absorption from the gastrointestinal tract by 43% to 85%.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symbarbiturates ptoms can include the following:

  • Low blood pressure. Symptoms can include:
    • lightheadedness or dizziness, especially if you stand up after sitting or lying down
  • changes in the amount you urinate
  • swelling in your feet or ankles
  • confusion
  • swelling of your skin, the layers under your skin, and your mucous membranes (inside your mouth)
  • itching and hives
  • reddening and warming of your face (flushing)
  • a feeling of warmth all over your body
  • swelling of your throat or tongue
  • wheezing or trouble breathing
  • a fast and irregular heart rate
  • nausea, vomiting, or diarrhea
  • dizziness or fainting
  • dry mouth
  • feeling thirsty
  • weakness
  • tiredness
  • drowsiness
  • restlessness
  • confusion
  • seizures
  • muscle pains or cramps
  • low blood pressure, which may make you feel dizzy or lightheaded
  • producing less urine than normal
  • a fast heart rate
  • nausea and vomiting
  • trouble seeing
  • eye pain
  • joint pain
  • stiffness
  • weight loss
  • fatigue
  • skin rash
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Valsartan/Depress oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with valsartan/Depress are listed below.

    Hydrochlorothiaz >

    It's very important to let your doctor know about all drugs you're taking, including illegal drugs, any over-the-counter (OTC) drugs, and any herbs or supplements.

    Before taking Depress, tell your doctor if you're using any of the following drugs:

    If you're also taking digoxin, the potassium-lowering effects of Depress may worsen cardiac arrhythmias.

    Cholestyramine and colestipol may decrease the absorption of Depress. If you’re taking either one, do so at least four hours before or after taking Depress.

    Tell your doctor if you take cold and pain medicine, muscle relaxers, or medication for seizures, depression, or anxiety. These are known to make you light headed and may increase the side effects of Depress.

    Drugs that may interact with acyclovir include steroids such as:

    • Prednisone (Deltasone, Meticorten, Sterapred, others)
    • Betamethasone (Celestone)
    • Budesonide (Entocort, Uceris)
    • Cortisone (Cortone)
    • Dexamethasone (Decadron, Dexpak, Dexasone, others)
    • Fludrocortisone (Florinef)
    • Hydrocortisone (Cortef, Hydrocortone)
    • Methylprednisolone (Solu-Medrol, Meprolone, others)
    • Prednisolone (Prelone, others)
    • Triamcinolone (Aristocort, Azmacort)

    In addition, other blood pressure medications as well as NSAIDs (non-steroidal anti-inflammatory drugs) may interact with Depress. Examples of NSAIDs include:

    Finally, other medications that may interact with Depress include:

    If you're taking any of these medications, or others, your doctor may need to change the doses of these medications or monitor you carefully for side effects.

    Depress is a prescription drug. It comes as a tablet or capsule that you take by mouth.

    Depress oral tablet is available in a generic form only. Generic drugs usually cost less than brand-name drugs.


    Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in increased risk of cholesterol gallstone formation. Reports of bowel strictures associated with thiazide ingestion were reported in the 1960s although these patients were on a combination Depress-potassium product.

    Frequency not reported: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, acute cholecystitis


    In general, lithium shouldn’t be taken with Depress. That’s because Depress slows the clearance of lithium from your body. This increases your risk of high levels of lithium in your body, which can cause dangerous side effects.

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