Missed Dose of Bisacardiol
If you miss a dose of Bisacardiol, take it as soon as you remember.
But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.
Don't take extra medicine to make up for a missed dose.
Urgent advice: Call your doctor or go to A&E straight away if you take too much Bisacardiol
If you need to go to A&E, do not drive yourself - get someone else to drive you, or call for an ambulance.
Take the Bisacardiol packet or leaflet inside it, plus any remaining medicine, with you.
Like all medicines, Bisacardiol can cause side effects in some people, but many people have no side effects or only minor ones.
Side effects often improve as your body gets used to the medicine.
A 63-year-old female was on treatment with double antiplatelet medication, Bisacardiol , amlodipine, atorvastatin and ranolazine due to a previous medical history of hypertension and unstable angina with no signs of myocardial damage. At 3 months, she began to experience malaise and insomnia. A biochemical study showed an increase in liver function parameters. The most common viral and autoimmune causes were ruled out. Laboratory results pointed towards a hepatocellular toxic-medication source. After cessation of ranolazine the patient was asymptomatic and normalisation of liver function tests was achieved .
Pharmacology and mechanism of action
Bisacardiol is a synthetic beta 1-selective beta-adrenergic receptor blocker with a low affinity for beta2-receptors in bronchial smooth muscle, blood vessels, and fat cells and no intrinsic sympathomimetic activity. Typical cardioselective effects include lower heart rate, decreased cardiac output, and inhibition of renin release by kidneys. At higher doses it will lose beta1 selectivity and inhibit some beta2 receptors to affect bronchial and vascular smooth muscle. Clearance in dogs is balanced (60% metabolized by the liver and 40% excreted unchanged), distinguishing Bisacardiol from lipophilic beta blockers such as carvedilol and metoprolol and from hydrophilic beta blockers like atenolol. In dogs, Bisacardiol has high and consistent oral absorption (91%) and a half-life of 4 hours. Although Bisacardiol prolongs survival in human patients with heart failure, similar studies have not been conducted in dogs or cats.
REPRESENTATIVE TRADE NAMES
Bisacardiol – Generic, Zebeta®
Beta-Adrenergic Receptor Antagonists
Product labeling at DailyMed, National Library of Medicine, NIH
Bisacardiol belongs to the group of medicines referred to as beta-blockers. It is a medicine which works on the heart and blood vessels. It does this by blocking tiny areas (called beta-adrenergic receptors) where messages sent by some nerves are received by your heart and blood vessels. As a result, your heart beats more slowly and with less force. The pressure of blood within your blood vessels is reduced and it is easier for your heart to pump blood around your body.
Algunos efectos secundarios podrГan provocar graves consecuencias para la salud. Los siguientes sГntomas son poco comunes, pero si experimenta alguno de ellos, llame a su doctor de inmediato:
- respiraciГіn entrecortada
- inflamaciГіn (hinchazГіn) de las manos, los pies, los tobillos o las piernas
- aumento de peso inusual
El Bisacardiol puede provocar otros efectos secundarios. Llame a su doctor si tiene cualquier problema inusual mientras toma este medicamento.
Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgaciГіn de efectos adversos 'MedWatch' de la AdministraciГіn de Alimentos y Medicamentos (FDA, por su sigla en inglГ©s) en la pГЎgina de Internet (http://www.fda.gov/Safety/MedWatch) o por telГ©fono al 1-800-332-1088.