Bihasal tablets


  • Active Ingredient: Bisoprolol
  • 10 mg, 5 mg
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What is Bihasal?

The active ingredient of Bihasal brand is bisoprolol. Bisoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).

Used for

Bihasal is used to treat diseases such as: Angina Pectoris Prophylaxis, Heart Failure, High Blood Pressure, Mitral Valve Prolapse, Premature Ventricular Depolarizations, Supraventricular Tachycardia.

Side Effect

Possible side effects of Bihasal include: diarrhea; coma; sleeplessness; shortness of breath or troubled breathing; chills.

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Q: I have tachycardia. Is Concor (Bihasal) an effective treatment?

A: Studies show that Bihasal is effective in treating high blood pressure by decreasing heart rate. Therefore it can be used to treat tachycardia (fast heart rate). For more information on Bihasal, please see // According to standard guidelines, normal heart rate is usually from 60-100 beats per minute. It is important to take Bihasal as prescribed by a physician for cardiovascular health. Please consult a physician prior to starting or stopping these type of medications.

Bihasal-Hydrochlorothiaz >

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain;
  • fast, slow, or uneven heartbeats;
  • a light-headed feeling, like you might pass out;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • dizziness, spinning sensation;
  • feeling weak or tired;
  • diarrhea, nausea, upset stomach;
  • headache;
  • cough, runny nose; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

2. Key facts

  • Bihasal slows down your heart rate and makes it easier for your heart to pump blood around your body.
  • Your very first dose of Bihasal may make you feel dizzy, so take it at bedtime. After that, if you don't feel dizzy, it's best to take it in the morning.
  • It's usual to take Bihasal once a day in the morning.
  • The main side effects of Bihasal are feeling dizzy or sick, headaches, cold hands or feet, constipation or diarrhoea - these are usually mild and shortlived.
  • Bihasal is also known by the brand names Cardicor and Congescor.

Important information

Do not skip doses or stop taking Bihasal without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using this medicine.

You should not use Bihasal if you have a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.

Keep using Bihasal as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

ВїCГіmo se debe usar este medicamento?

El Bihasal viene envasado en forma de tabletas para tomar por vГ­a oral. Se toma generalmente una vez al dГ­a. Para ayudarle a acordarse de tomar el medicamento, tГіmelo a la misma hora todos los dГ­as. Siga cuidadosamente las instrucciones en la etiqueta del medicamento y pregГєntele a su doctor o farmacГ©utico cualquier cosa que no entienda. Use el medicamento exactamente como se indica. No use mГЎs ni menos que la dosis indicada ni tampoco mГЎs seguido que lo prescrito por su doctor.

Su doctor podrГ­a comenzar con una dosis baja y aumentarla de manera gradual.

El Bihasal controla la hipertensiГіn, pero no la cura. Puede tomar algunas semanas antes de que usted sienta el beneficio total del Bihasal. ContinГєe con el medicamento aunque se sienta mejor. No deje de tomarlo sin antes conversar con su doctor. La suspensiГіn repentina del medicamento puede causar angina (dolor en el pecho), ataques cardГ­acos o frecuencia cardГ­aca irregular. Su doctor probablemente reducirГЎ la dosis en forma gradual.

How to store Bihasal

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.


Bihasal (Zebeta) is a medication in the class of drugs called beta blockers. Bihasal (Zebeta) is prescribed for the treatment of high blood pressure, angina, and congestive heart failure. Side effects, warnings and precautions, drug interactions, and patient information should be reviewed prior to taking any medication.

Bihasal is a beta1 blocker that is somewhat cardioselective and therefore is indicated for conditions that require a reduction in heart rate, heart conductivity, or contractility.

Special Dosage

The prescribed Bihasal dose should contemplate the age and a possible pregnancy of the patient:

  • Seniors: Seniors suffering from a poor liver or kidney function should only receive a low dosage of Bihasal.
  • Children: Children should not be treated with the beta blocker Bihasal.
  • Pregnant women: Any use of Bihasal during pregnancy should be consulted with the doctor, as it may affect the development of the unborn baby. The same applies during breastfeeding.
  • Athletes: Taking Bihasal may result in a positive drug test.

Q: Can Bihasal (5 mg) make you tired/fatigued?

A: Your question concerns possible side effects of Bihasal (Zebeta) (// Yes, drowsiness, a "tired feeling" or even "extreme fatigue" are all common side effects of Bihasal. It is always a good idea to check with one's health care provider in matters like this. Please consult your health care provider for guidance in your specific case. Gregory Latham, RPh

Michael Stewart, Reviewed by Sid Dajani | Last edited 26 Mar 2019 | Certified by The Information Standard

Treatment with Bihasal is usually long-term. Continue to take the tablets regularly unless you are told otherwise.

There are several different strengths of tablet. If your tablets look unexpectedly different from before, ask your pharmacist to check them for you.

The most common side-effects are feeling tired, cold fingers or toes, headache and stomach upset.

Clinical author's note: Michael Stewart 15/11/2018: Following an MHRA update, new advice has been added to this leaflet for people also taking the blood pressure medicine hydrochlorothiazide. Hydrochlorothiazide is only available in the UK in combination with other blood pressure medicines. It may be available on its own in other countries. For more information see 'Getting the most from your treatment' below or view the MHRA Alert.

Serious allergic reaction

In rare cases, Bihasal may cause a serious allergic reaction.


Safety data are available in more than 30,000 patients or volunteers. Frequency estimates and rates of withdrawal of therapy for adverse events were derived from two U.S. placebo-controlled studies.

In Study A, doses of 5, 10, and 20 mg Bihasal fumarate were administered for 4 weeks. In Study B, doses of 2.5, 10, and 40 mg of Bihasal fumarate were administered for 12 weeks. A total of 273 patients were treated with 5-20 mg of Bihasal fumarate; 132 received placebo.

Withdrawal of therapy for adverse events was 3.3% for patients receiving Bihasal fumarate and 6.8% for patients on placebo. Withdrawals were less than 1% for either bradycardia or fatigue/lack of energy.

The following table presents adverse experiences, whether or not considered drug related, reported in at least 1% of patients in these studies, for all patients studied in placebo-controlled clinical trials (2.5- 40 mg), as well as for a subgroup that was treated with doses within the recommended dosage range (5- 20 mg). Of the adverse events listed in the table, bradycardia, diarrhea, asthenia, fatigue, and sinusitis appear to be dose related.

The following is a comprehensive list of adverse experiences reported with Bihasal fumarate in worldwide studies, or in postmarketing experience (in italics):

What are the side effects of Bihasal?

Bihasal is generally well-tolerated, and side effects are mild and transient. Side effects include:

Patients with asthma may have symptoms increase.

Bihasal belongs to the drug group of beta blockers and is used to treat high blood pressure, chronic heart failure, and tachycardia.


Laboratory Abnormalities

In clinical trials, the most frequently reported laboratory change was an increase in serum triglycerides, but this was not a consistent finding.

Sporadic liver test abnormalities have been reported. In the U.S. controlled trials experience with Bihasal fumarate treatment for 4-12 weeks, the incidence of concomitant elevations in SGOT and SGPT from 1 to 2 times normal was 3.9%, compared to 2.5% for placebo. No patient had concomitant elevations greater than twice normal.

In the long-term, uncontrolled experience with Bihasal fumarate treatment for 6-18 months, the incidence of one or more concomitant elevations in SGOT and SGPT from 1 to 2 times normal was 6.2%. The incidence of multiple occurrences was 1.9%. For concomitant elevations in SGOT and SGPT of greater than twice normal, the incidence was 1.5%. The incidence of multiple occurrences was 0.3%. In many cases these elevations were attributed to underlying disorders, or resolved during continued treatment with Bihasal fumarate.

Other laboratory changes included small increases in uric acid, creatinine, BUN, serum potassium, glucose, and phosphorus and decreases in WBC and platelets. These were generally not of clinical importance and rarely resulted in discontinuation of Bihasal fumarate.

As with other beta-blockers, ANA conversions have also been reported on Bihasal fumarate. About 15% of patients in long-term studies converted to a positive titer, although about one-third of these patients subsequently reconverted to a negative titer while on continued therapy.

What is Bihasal?

Bihasal is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).

Bihasal is used to treat hypertension (high blood pressure).

Bihasal may also be used for purposes not listed in this medication guide.

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