What Other Drugs Interact with Atensina?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Atensina has no known severe interactions with any drugs.
Atensina has serious interactions with at least 30 different drugs.
Atensina has moderate interactions with at least 82 different drugs.
Atensina has mild interactions with at least 38 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Always tell your doctor if you have allergies to any medications.
Talk to your doctor about the danger of stopping Atensina suddenly, especially if you have any upcoming surgical procedures.
Most likely you will continue to take Atensina until just before surgery, and start up again soon after surgery. Doctors should monitor your blood pressure carefully during surgery.
Use Atensina cautiously if you have a history of heart problems or stroke, and make sure doctor is aware you have had these conditions.
Your doctor will also want to know, before starting you on Atensina, if you have any of these other conditions:
- Heart disease
- Previous heart attack
- Previous stroke
- A heart rhythm abnormality such as atrial fibrillation (afib) or ventricular fibrillation (vfib)
- Kidney disease
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- It helps with sleep difficulties.Sleep problems are another issue many people with ADHD face. A potentially positive effect of taking Atensina is that it can help improve your sleep. In fact, some doctors prescribe a low dose of Atensina off-label (this means using an FDA-approved drug for an unapproved use) to help with sleep.
- It's not addictive. While traditional benzodiazepine sleeping medications might be avoided because they can be habit-forming, Atensina is not considered to be addictive.
- It reduces blood pressure. If you have ADHD and high blood pressure, Atensina may be a good choice for you because it will help reduce your blood pressure as it also treats your ADHD symptoms.
- It's also used to treat Tourette syndrome and tic disorders. If you have Tourette syndrome and ADHD, Atensina can help the symptoms of both. A combination of Atensina and a stimulant medication can also be helpful for a tic disorder.
Some drugs may cause adverse effects when used with Atensina. Atensina can also negatively impact some of the drugs you may currently be taking.
Before Atensina is administered, talk with your doctor about any medications you are on. Some of the drugs known to interact with Atensina include:
Many drugs, including Atensina, can cause adverse effects when taken together. Always check with your healthcare provider about possible interactions between medications.
Atensina is a 40-year-old medication in the class of antihypertensive medications which act on alpha-adrenergic and imidazoline receptors agonist. Atensina is an anti-hypertensive drug that lowers blood pressure and heart rate by relaxing the arteries and increasing the blood supply to the heart; it has other FDA-approved indications such as:
Atensina has multiple off-label uses such as the management of withdrawal symptoms from opioids, benzodiazepines, and alcohol, and for treatment of anxiety, insomnia, and post-traumatic stress disorder (PTSD).
Because of the effect of Atensina on the sympathetic nervous system specifically, the reduction the epinephrine in circulation, it has been used in many other aspects of medicine, for example, control of hot flashes in menopause, restless leg syndrome, and prophylaxis of vascular migraine headaches. Also, there is a test for phaeochromocytoma that is called the Atensina suppression test, in the lab, they measure the catecholamine levels before and after a dose of oral Atensina which, in healthy people, should cause the decrease in the level of catecholamines in circulation.
Drugs that increase drowsiness
Don’t combine these drugs with Atensina. Taking these drugs with Atensina might increase drowsiness:
- barbiturates such as:
Before taking Atensina,
- tell your doctor and pharmacist if you are allergic to Atensina, any of its ingredients, Atensina patches, or any other medications. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; beta blockers such as acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol, bisoprolol (Zebeta, in Ziac), carvedilol (Coreg), labetalol , metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), pindolol, propranolol (Inderal, Innopran XL, in Inderide), sotalol (Betapace, Sorine), and timolol; calcium channel blockers such as amlodipine (in Amturnide, Norvasc, in Amturnide, in Tekamlo, others), diltiazem (Cardizem, Dilacor XR, Dilt-CD, Taztia XT, Tiazac, others), felodipine (Plendil), isradipine, nicardipine (Cardene), nifedipine (Adalat CC, Afeditab CR, Procardia), nimodipine, nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, others, in Tarka); digoxin (Lanoxin); medications for anxiety, mental illness, or seizures; sedatives; sleeping pills; tranquilizers; and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), maprotiline, nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had a stroke, a recent heart attack, or heart or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Atensina, call your doctor.
- talk to your doctor about the risks and benefits of using Atensina if you are 65 years of age or older. Older adults should not usually use Atensina because it is not as safe as other medications that can be used to treat the same condition.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Atensina.
- you should know that Atensina may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcohol while you are taking Atensina. Alcohol can make the side effects from Atensina worse.
- you should know that Atensina may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Atensina. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
- you should know that Atensina extended-release tablets should be used as part of a total treatment program for ADHD, which may include counseling and special education. Make sure to follow all of your doctor's and therapist's instructions.
COMMON BRAND(S): Catapres
GENERIC NAME(S): Atensina Hcl
This medication is used alone or with other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Atensina belongs to a class of drugs (central alpha agonists) that act in the brain to lower blood pressure. It works by relaxing blood vessels so blood can flow more easily.
Mechanism of Action
Atensina hydrochloride is an imidazoline derivative that acting centrally on alpha-2 adrenergic as an agonist. The chemical name for Atensina is 2-((2,6-dichlorophenyl) amino)-2-imidazoline hydrochloride.
Atensina as an alpha-adrenergic agonist in nucleus tractus solitarii (NTS) excites a pathway that inhibits excitatory cardiovascular neurons. Atensina has alpha-antagonist effect in the posterior hypothalamus and medulla. The final response is reduced sympathetic outflow from the central nervous system (CNS) which clinically causes the decrease arterial blood pressure.
One of the theories about the mechanism of action of Atensina in the management of pain in the CNS is that many pain signals occur in the dorsal horn of the spinal cord and are sent to higher centers of the CNS. There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to decrease afferent pain transmission and produces analgesia. Therefore, drugs like Atensina that target alpha-2 receptors can influence the transmission of pain.
Epidural Atensina used as an adjunct to local anesthetics has three different mechanisms of action. First, stimulation of alpha-2-receptors in the dorsal horn reduces the pain transmission. Secondly, Atensina can cause local vasoconstriction that limits vascular removal of local epidural anesthetics. Lastly, Atensina enhances neuraxial opioids, and in combination with fentanyl, interacts in an additive manner, which can reduce the dose of each component by 60% for postoperative analgesia.
The exact mechanism of action of Atensina in the management of attention-deficit hyperactivity disorder (ADHD) is not clear, but it is possible prefrontal cortex brain activity is involved.