Amdopin tablets

Amdopin

  • Active Ingredient: Amlodipine
  • 10 mg, 5 mg, 2.5 mg
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What is Amdopin?

The active ingredient of Amdopin brand is amlodipine. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

Used for

Amdopin is used to treat diseases such as: Angina, Coronary Artery Disease, Heart Failure, High Blood Pressure, Migraine Prevention, Raynaud's Syndrome.

Side Effect

Possible side effects of Amdopin include: chest pain or discomfort; unable to sleep; dizziness; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; clay-colored stools; painful or difficult urination.

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Dosage of Amdopin Besylate

Dosage for the patients suffering from High blood pressure (hypertension):

Adult Dosage (ages 18-64 years)

  • Starting dose: 5 mg taken by mouth once per day.
  • Dose increases: Your doctor can change your dose based on your blood pressure levels. If your blood pressure is still not under control after 7–14 days, your doctor may increase your dose.
  • Maximum dose: 10 mg per day.

Child Dosage (ages 0-5 years): This medicine hasn’t been studied in children and shouldn’t be used in children younger than 6.

Child Dosage (ages 6-17 years): 2.5–5 mg taken by mouth once per day. Doses above 5 mg haven’t been studied in children and shouldn’t be used.

Senior Dosage (ages 65 years and older):

  • The recommended dose is 2.5 mg taken by mouth once per day.
  • Older people may course medicines more gradually over time. A regular adult dosage can create amounts of Amdopin to be more than normal level. If you’re a senior, you require a lower dose.

Special Considerations

Liver Disease: The Suggested dosage is 2 .5 mg taken by mouth once daily. Amdopin is treated by your liver. If your liver isn’t performing nicely, then more of this drugs may remain in your body for longer. This puts you prone to unwanted side effects. If you have serious liver difficulties, you will need less dose or a separate dosing routine.

More common side effects

The more common side effects that occur with Amdopin/benazepril include:

  • cough
  • dizziness
  • headache
  • swelling of your feet, ankles, and hands

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Cautions

Symptomatic hypotension with or without syncope possible, particularly with severe aortic stenosis; because of gradual onset of action, acute hypotension unlikely.

Worsening of angina and acute myocardial infarction (MI) can develop after dose is started or increased, particularly with severe obstructive CAD.

Peripheral edema may develop within 2-3 weeks of starting therapy.

Use with caution in patients with hypertrophic cardiomyopathy; reduction in afterload may worsen symptoms associated with this condition.

May reduce coronary perfusion and result in ischemia in patients with severe aortic stenosis; use caution.

Extensively metabolized by liver; titrate dose slowly with severe hepatic impairment.

Initiate at lower dose in the elderly.

Titrate dose every 7-14 days on a given dose; peak antihypertensive effect is delayed.

Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to Amdopin and may require dose reduction; monitor for symptoms of hypotension and edema when Amdopin is co-administered with CYP3A inhibitors to determine the need for dose adjustment.

Amdopin may increase systemic exposure of cyclosporine or tacrolimus when co-administered; frequent monitoring of trough blood levels of cyclosporine and tacrolimus recommended; adjust dose when appropriate

Hepatotoxicity

Chronic therapy with Amdopin is associated with a low rate of serum enzyme elevations at rates that are similar to matched control populations. The enzyme elevations are usually mild, transient and asymptomatic and may resolve even during continued therapy. Clinically apparent liver injury from Amdopin is rare and described only in isolated case reports. In the few idiosyncratic cases reported, the latency period to onset of liver injury was usually 4 to 12 weeks, but examples with prolonged latency have also been published (10 months and several years). The latency period is shorter with recurrence on reexposure, including several instances of recurrence after liver injury due to other calcium channel blockers. The pattern of serum enzyme elevations is usually mixed or cholestatic. Rash, fever and eosinophilia have not been described and autoantibodies are not typical.

Likelihood score: C (probable but rare cause of clinically apparent liver injury).

Outcome and Management

The severity of liver injury from Amdopin ranges from mild and transient serum enzyme elevations to self-limited jaundice. Complete recovery is expected after stopping the drug and recovery is usually rapid (4 to 8 weeks). Cases with chronic or fulminant liver injury due to Amdopin have not been reported. Little information is available on recurrence with rechallenge but there may be some degree of cross-sensitivity to hepatotoxicity with other calcium channel blockers.

Drug Class: Cardiovascular Agents, Calcium Channel Blockers

Special dosage considerations

For people with liver problems: Amdopin/benazepril is processed by your liver. If your liver isn’t working well, more of the drug may stay in your body longer, putting you at risk for side effects. If you have severe liver problems, your doctor will likely start you on 2.5 mg Amdopin/10 mg benazepril.

For people with kidney problems: Your dosage of Amdopin/benazepril doesn’t need to be adjusted if you have mild or moderate kidney disease. If you have severe kidney disease, you shouldn’t use this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Amdopin/benazepril oral capsule is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

What to do if you miss a dose: If you miss a dose, take it as soon as you remember. If it’s been more than 12 hours since you missed a dose, skip the missed dose and just take your next dose at the regular time.

If you skip or miss doses: If you skip or miss doses, your blood pressure may get worse. This could lead to serious problems, such as stroke or heart attack.

If you take too much: You have a higher risk of having side effects caused by this drug. You may also have the following symptoms:

  • trouble breathing
  • very low blood pressure
  • fast heartbeats

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You’ll know whether this drug is working when you check your blood pressure at home. If your blood pressure is at or below the goal your doctor set for you, the medication is working.

Keep these considerations in mind if your doctor prescribes Amdopin/benazepril for you.

Amdopin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • swelling of the hands, feet, ankles, or lower legs
  • headache
  • upset stomach
  • nausea
  • stomach pain
  • dizziness or lightheadedness
  • drowsiness
  • excessive tiredness
  • flushing

How it works

Amdopin belongs to a class of drugs called calcium channel blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Amdopin blocks calcium from entering certain tissues and arteries. This makes it easier for them to relax so that blood can flow more easily to your heart. This in turn helps lower your blood pressure, and reduces your risk of heart attack or stroke. If you’re taking Amdopin for chest pain, this drug reduces your risk of hospitalization and surgeries due to chest pain.

Amdopin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with Amdopin are listed below.

On this page

  1. About Amdopin
  2. Key facts
  3. Who can and can't take Amdopin
  4. How and when to take it
  5. Side effects
  6. How to cope with side effects
  7. Pregnancy and breastfeeding
  8. Cautions with other medicines
  9. Common questions

How to use Amdopin BESYLATE

Read the Patient Information Leaflet if available from your pharmacist before you start taking Amdopin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

Some brands of the liquid form of this medication should be shaken before use, while other brands should not be shaken before use. Check the manufacturer's information or ask your pharmacist for specific directions. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

If used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase, chest pain continues or worsens).

Q: I just started Norvasc and have hypothyroidism. Could this medicine affect my thyroid?

A: Norvasc (Amdopin) is a calcium channel blocker used to treat high blood pressure and other heart conditions. Generally speaking, drug interactions fall into three main categories: Drug-drug (i.e., prescription, over-the-counter, herbals, dietary supplements) interactions occur when two or more drugs react with each other. Drug-diet (food/drink) interactions result from drugs reacting with foods or drinks. Drug-disease interactions may occur when an existing medical condition makes certain drugs potentially harmful. Potential drug interactions 1) Norvasc has an interaction with grapefruit juice. It is best to avoid grapefruit and grapefruit juice while taking Norvasc. Taking them together may lead to increased side effects from Norvasc. According to prescribing information, Norvasc is not expected to affect the thyroid. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD., BCPS

Before you start taking Amdopin Besylate, inform your doctors if:

  • If you had any liver problems
  • Had heart attack
  • If you have any allergies to any other medicines, or foods.
  • If you are pregnant or you are planning for a pregnancy.
  • If you are breastfeeding.
  • If you are planning to have any surgery.

Do not take this Amdopin Besylate if:

  • You had an allergic reaction after taking this medication earlier.
  • If you don’t remember the dose prescribed by your doctor.
  • If the expiry date has passed.
  • If the package is torn.

What should I avoid while taking Amdopin?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.


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