WHAT IS AMLODIPINE?
Amdocal is a long-acting calcium channel blocker used as an anti-hypertensive, and in the treatment of angina. As with other calcium channel blockers, Amdocal acts by relaxing the smooth muscles in the arterial wall, decreasing peripheral resistance and hence improving blood pressure. In angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. Amdocal is marketed as Norvasc®, as well as under various other names.
Before taking Amdocal,
- tell your doctor and pharmacist if you are allergic to Amdocal, any other medications, or any ingredients in Amdocal tablets or suspension. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin, Phenytek), and phenobarbital; clarithromycin (Biaxin, in Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); efavirenz (Sustiva); indinavir (Crixivan); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); lovastatin (Altoprev, in Advicor); nefazodone; nelfinavir (Viracept); nevirapine (Viramune); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate), ritonavir (Norvir, in Kaletra), simvastatin (Zocor, in Simcor, in Vytorin), and tacrolimus (Astragraf SL, Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had heart failure or heart or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Amdocal, call your doctor.
Amdocal, sold under the brand name Norvasc among others, is a medication used to treat high blood pressure and coronary artery disease.
References updated: 01 March 2016
1800 controls reported similar rate of ALT elevations with Amdocal as with hydrochlorthiazine , and no serious liver toxicity).
50,000 liver transplants reported to UNOS between 1990 and 2002, 270 were done for drug induced acute liver failure, but none were attributed to a calcium channel blocker).
Taking certain pain medications with Amdocal/benazepril can decrease your kidney function. Examples of these drugs include:
- nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
This drug must be stored at the right temperature:
- Store Amdocal at room temperature between 59°F and 86°F (15°C and 30°C).
- Store this drug in its original container and keep it tightly closed.
- Keep this drug away from light.
- Don’t store this medication in moist or damp areas, such as bathrooms.
COMMON BRAND(S): Katerzia, Norvasc
GENERIC NAME(S): Amdocal
OTHER NAME(S): Amdocal Tablet
Amdocal is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amdocal belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.
Amdocal is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.
Urgent advice: Call your doctor or go to A&E straight away if you take too much Amdocal
If you need to go to an A&E, do not drive yourself - get someone else to drive you or call for an ambulance.
Take the Amdocal packet or leaflet inside it, plus any remaining medicine, with you.
Like all medicines, Amdocal can cause side effects, although not everyone gets them.
Side effects often improve as your body gets used to the medicine.
Amdocal can cause a severe allergic reaction. Symptoms include:
- trouble breathing
- swelling of your throat or tongue
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These aren't all the side effects of Amdocal.
For a full list, see the leaflet inside your medicine packet.
You can report any suspected side effect to the UK safety scheme.
Q: I take Norvasc. Is it safe to eat grapefruit with that medication?
A: There is nothing in the literature that reveals any significant interactions between the calcium channel blocker Norvasc (Amdocal) and grapefruit.
Taking simvastatin with Amdocal can cause the levels of this cholesterol medication to increase in your body. This may lead to more side effects.
People with a known sensitivity to Amdocal should not take Norvasc.
Though Norvasc is used to treat angina, worsening chest pain and heart attacks can develop after starting or increasing your dose of the drug — this is especially true for people with severe obstructive coronary artery disease.
Norvasc can also cause symptomatic hypotension (low blood pressure), particularly in people with a heart valve problem called aortic stenosis.
Before starting Norvasc, let your doctor know if you ever had heart disease or liver problems, as you may require a different course of Norvasc treatment.