Aldactazine tablets

Aldactazine

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Aldactazine?

The active ingredient of Aldactazine brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Aldactazine is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Aldactazine include: clear or bloody discharge from the nipple; loss of appetite; muscle pain or cramps; vomiting of blood or material that looks like coffee grounds; painful or difficult urination.

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Side Effects

While Aldactazine has been proven to be effective – over time – in combating both hirsutism (excess hair growth) and acne in women with Polycystic Ovary Syndrome (PCOS ), it is also important to consider the potential side effects this drug may cause in your body.

The list of potential side effects from Aldactazine is extensive and worrisome; including side effects such as: headaches, diarrhea, cramps, stomach pain, drowsiness, fatigue or lack of energy, rashes, nausea and vomiting.

Ironically – particularly for women with PCOS – this drug can also cause irregular and abnormal menstrual periods and bleeding, irregular or increased hair growth on parts of the body and scalp hair loss; all symptoms of PCOS !10 Patients should be aware that Aldactazine could aggravate some of their PCOS symptoms.

Other, more serious side effects include (but are not limited to):

  • Fluid and electrolytes imbalance (including: low sodium, low magnesium and high potassium)
  • Tarry black stools
  • Breast enlargement and tenderness
  • Confusion and/or unsteadiness
  • Inability to move arms or legs
  • Yellowing of the skin or eyes
  • Difficulty with breathing
  • Difficulty with urination
  • Rapid Heartbeat or changes in heartbeat
  • Numbness, tingling, pain or burning in the hands or feet
  • Pain in the upper right part of the stomach
  • Flu-like Symptoms

Also, because of the effect of Aldactazine on the body’s potassium levels, your doctor should give you detailed advice for a reduced-salt (sodium) diet and daily exercise program. Avoid potassium-containing salt substitutes while you are taking this medication. Also talk with your doctor about the amount of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) that you may have in your diet.

The good news is that if you experience any of these side effects while taking Aldactazine, they will usually go away once you stop using the drug. Whether to take Aldactazine or not is an important decision best left to you and your doctor. You must consider the many potential side effects, combined with your own current medical history, to make an informed decision.

What other drugs will affect Aldactazine?

Taking this medicine with other drugs that make you dizzy or lower your blood pressure can worsen these effects. Ask your doctor before taking a sleeping pill, opioid pain medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

heart or blood pressure medicine (especially ace inhibitors, angiotensin receptor blockers, or another diuretic);

medicine to prevent a blood clot; or

This list is not complete. Other drugs may interact with Aldactazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Generic Name: Aldactazine (spir ON oh LAK tone)Brand Names: Aldactone, CaroSpir

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 9, 2018.

Aldactazine for Acne

Aldactazine is sometimes used off-label to treat women with persistent adult acne due to increased androgen levels, because the drug is able to inhibit the activity of sebaceous glands (small skin glands that releases an oily, lubricating substance called sebum).

The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess.

Why is this medication prescribed?

Aldactazine is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Aldactazine is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Summary

Aldactone (Aldactazine) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat diuretic induced low potassium and high blood pressure. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to taking any medication.

Rated Aldactazine (Aldactone) for Acne Report

I was on hormonal BCP since I was 17 and stopped taking it at 26 because the estrogen was giving me migraines. I got the nexplanon implant that doesn't contain estrogen, and after a month I had horrible hormonal acne all over my chin and started getting cystic acne mostly on my cheeks. I got prescribed spiro and a retinol cream. The first week I took 50 mg of spiro and after that started taking 100 mg daily. It's been a little less than 2 months but most of my acne is gone, mostly scarring is left. The retinol dries out my skin a lot so I use it every other night. Within the past couple of weeks I've been experiencing food aversions and nausea, so I'm still trying to figure out how to deal with that. I think the pros definitely outweigh the cons of taking spiro, it's still early on so I'm hoping it will continue to improve my acne. I think some people who have had negative experiences might need to fix their diet. I've always been pretty conscious of what I eat, making sure I have fruits/veggies everyday (fiber) and drink a gallon of water per day. I'm not sure about taking spiro long term due to the possible side effects though.

Digoxin

Taking digoxin with Aldactazine may increase the effects of digoxin. Your doctor may monitor you closely if you take these drugs together.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.


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