Aldactacine tablets

Aldactacine

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Aldactacine?

The active ingredient of Aldactacine brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Aldactacine is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Aldactacine include: lump in the breast or under the arm; vomiting of blood or material that looks like coffee grounds; chest pain; nervousness; redness or swelling of the breast.

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Rated Aldactacine (Aldactone) for Hypertension Report

i was taking it for high blood pressure, and also I was overweight. It worked like a charm my BP was right on the dot and I lost 65 lbs in 3 months, I felt great. Then I came off of it and over time my BP is high again and all the weight I lost came back and I have been feeling like crap ever since. I will be going to my Dr, to be put back on it.

Before taking this medicine

You should not use Aldactacine if you are allergic to it, or if you have:

Addison's disease (an adrenal gland disorder);

high levels of potassium in your blood (hyperkalemia);

if you are unable to urinate; or

if you are also taking eplerenone.

To make sure Aldactacine is safe for you, tell your doctor if you have ever had:

an electrolyte imbalance (such as low levels of magnesium in your blood);

In animal studies, Aldactacine caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk.

It is not known whether Aldactacine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Aldactacine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Complications

When considering whether or not to take Aldactacine to address your androgen-related PCOS symptoms, you should be aware of the following cautions regarding this drug, in order to avoid potentially dangerous complications:

    • Potassium supplementation and salt substitutes (containing potassium) should not be taken while taking Aldactacine as this may cause potentially high – and deadly – potassium levels in your body (a condition called hyperkalemia). Your potassium levels will need to be closely monitored, especially during the first twelve months of use and whenever the dosage is increased.

Rated Aldactacine (Aldactone) for Congestive Heart Failure Report

I have been taking 50mg./day for about a year now. I have developed gynecomastia which has developed to the extent that I wear a sports bra to hold my chest in and hide the development. My doctor will not take me off this drug since it seems to be helping my heart condition.

Cautions

Gynecomastia reported and usually reversible

Hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, and hyperglycemia may occur

Asymptomatic hyperuricemia can occur and rarely gout may occur; monitor serum electrolytes, uric acid, and blood glucose periodically In cirrhosis, avoid electrolyte and acid/base imbalances that might lead to hepatic encephalopathy

Hyperkalemia may occur; monitor serum potassium within 1 week of initiation or titration of Aldactacine and regularly thereafter; if hyperkalemia occurs, reduce dose or discontinue treatment and treat hyperkalemia

Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function, particularly in salt-depleted patients or those taking angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs)

Missed Dose of Aldactacine

Take your missed dose of Aldactacine as soon as you remember it.

Skip your missed dose if it's almost time for your next dose.

Don't "double-dose" to make up for a missed dose.

Aldactacine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • vomiting
  • diarrhea
  • stomach pain or cramps
  • enlarged or painful breasts in men or women
  • irregular menstrual periods
  • vaginal bleeding in post-menopausal ('after the change of life', the end of monthly menstrual periods) women
  • difficulty maintaining or achieving an erection
  • deepening of voice
  • increased hair growth on parts of the body
  • drowsiness
  • tiredness
  • restlessness

Treatment Options

So you doctor has suggested Aldactacine as a treatment option for your PCOS . What exactly is this drug, and how does it function in the body? Is this the right PCOS treatment for you?

Summary

Aldactone (Aldactacine) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat diuretic induced low potassium and high blood pressure. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to taking any medication.

Lithium

Taking lithium with Aldactacine can increase the effects of lithium. Your doctor may lower your dosage of lithium if you take these drugs together.

Warnings

Aldactacine has been shown to be tumorigenic in chronic toxicity studies in rats; use only for specified indications.

This medication contains Aldactacine. Do not take Aldactone if you are allergic to Aldactacine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Why is this medication prescribed?

Aldactacine is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Aldactacine is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Introduction

Aldactacine is an aldosterone receptor antagonist and potassium-sparing diuretic widely used in the therapy of edema, particularly in patients with cirrhosis in which hyperaldosteronism appears to play a major role. Aldactacine has been linked to rare cases of clinically apparent drug induced liver disease.


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