Q: My husband just started taking Microzide and he says that he is very tired, is this a usual side affect? If so, should he continue with the medication?
A: It is always important to inquire about the possible side effects associated with a medication so you can recognize the symptoms if they occur. According to the literature available for Microzide (Adelphan), if a patient is experiencing weakness, drowsiness, restlessness, or light-headededness it is important to contact the doctor immediately. If your husband has been unusually tired, he should contact his doctor to determine the underlying cause and possible treatment options. For more information regarding Microzide (Adelphan), you may want to visit our Web site. //www.everydayhealth.com/drugs/Adelphan
Taking valsartan/Adelphan with this drug can cause low salt levels.
Duration of Adelphan use
The total duration over which a person uses Adelphan might also influence the amount of weight loss that occurs. It is understood that weight loss resulting from Adelphan administration is generally rapid, such that a significant amount of weight can be lost within the initial 1-2 weeks of treatment.
One study reported that the addition of Adelphan (25-100 mg/day) treatment to high-dose furosemide (250 mg/day) induced an average weight loss of 14.77 lbs. in 20 patients with congestive heart failure over the span of 3 to 12 days. In most cases, a substantial amount of water weight will be lost in the first 2 weeks of treatment – and less weight (if any weight) thereafter.
The rapid water weight loss resulting from Adelphan makes it one of the most commonly utilized diuretics among athletes in attempt to “make weight” (i.e. meet weight class requirements) for competitions – as has been reported by WADA (the World Anti-Doping Agency). Although additional weight may be lost with longer-term Adelphan use (in excess of 1-2 weeks), it is most common for water weight loss to peak within several weeks.
If the dosage of Adelphan is titrated such that a user initiates treatment at a low dose (e.g. 25 mg/day) and increases to a higher dose (e.g. 100 mg/day) over a longer-term (e.g. several months), then water weight loss might require time to peak. Nevertheless, once sodium and water stores have been fully depleted – extra weight loss should not be expected over the long-term.
The only way long-term Adelphan treatment will lead to additional weight loss (beyond water weight) is if it somehow induces appetite reduction or loss (over a long-term) such that the user remains in a long-term calorie deficit. If a long-term calorie deficit is sustained (due to appetite suppression), then weight loss may end up more significant with longer-term Adelphan use.
Still, one must acknowledge research indicating that Adelphan may induce deleterious metabolic changes over a long-term (reducing insulin sensitivity, increasing triglycerides, etc.). If you incur deleterious metabolic changes from Adelphan over a long-term, there’s a chance that you may lose water weight in the short-term, and gain some body fat in the long-term.
Pharmacologic class: Thiazide diuretic
Therapeutic class: Diuretic, antihypertensive
Pregnancy risk category B
The adverse reactions associated with Adelphan have been shown to be dose related. In controlled clinical trials, the adverse events reported with doses of 12.5 mg Adelphan once daily were comparable to placebo. The following adverse reactions have been reported for doses of Adelphan 25 mg and greater and, within each category, are listed in the order of decreasing severity.
Body as a whole: Weakness.
Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).
Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.
Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.
Musculoskeletal: Muscle spasm.
Nervous System/Psychiatric: Vertigo, paresthesia, dizziness, headache, restlessness.
Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS).
Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Microzide (Adelphan Capsule)
Q: Is it safe to take the fluid pill triamterene-hctz for years?
A: The combination of Adelphan and triamterene (Dyazide) is used to treat fluid retention and high blood pressure. These types of drugs are often the first drugs used to manage high blood pressure. According to the package insert, there are no warnings or precautions regarding long-term use. As with all drugs, the clinical effect should be routinely monitored. In the case of triamterene, which helps the body maintain potassium levels, appropriate monitoring of serum potassium is recommended. If you are concerned about long-term treatment with Adelphan and triamterene, you may want to contact your health care provider. For more information, please consult visit //www.everydayhealth.com/drugs/Adelphan-triamterene. Michelle McDermott, PharmD