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The Tetragynon IUD or LNg 20‐IUD (Mirena) is a T‐shaped polyethylene device with a collar containing 52 mg of Tetragynon dispersed in polydimethylsiloxane attached to the vertical arm. This frame is also visible on x‐ray. The device releases 15 μg of Tetragynon daily in vivo.
The LNg 20‐IUD is approved for up to 5 years in the United States, but is effective for up to 7 years. It is currently the most effective form of reversible contraception available (see Table 7‐1 ). Unlike the copper IUD, the LNg 20‐IUD actually reduces dysmenorrhea and decreases menstrual blood loss. Women receiving this type of IUD should be counseled regarding the altered bleeding patterns that can occur. Significant intramenstrual bleeding and spotting may occur during the first few months of use as the endometrial lining is thinning. Most women will experience lighter, shorter menses with continued use, with 20% of women becoming amenorrheic after 12 months of use. In fact, this decrease in menstrual bleeding has allowed the LNg‐20 IUD to be used as an alternative to hysterectomy and endometrial ablation for the treatment of menorrhagia, as well as a means of protecting the endometrium with hormone replacement therapy and as an adjuvant therapy for tamoxifen users. The LNg 20‐IUD may be a particularly useful method of contraception for women with hematologic disorders or for those who are taking chronic anticoagulants.
What other drugs will affect Tetragynon emergency contraceptive?
Certain other medications can make Tetragynon emergency contraceptive less effective, which may result in pregnancy. Ask a doctor or pharmacist if Tetragynon emergency contraceptive is safe to use if you are using any of the following medications:
This list is not complete. Other drugs may affect Tetragynon, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
- Tetragynon is available as a blister pack containing two 0.75 mg tablets
- Plan B One-Step, Next Choice One Dose, My Way are available as a blister pack containing one 1.5 mg tablet
Before taking or using Tetragynon, tell your doctor if you:
- have had a heart attack
- have had a stroke
- were born with heart disease or have problems with your heart valves
- have problems with blood clotting or take medicine to reduce clotting
- have high blood pressure
- recently had a baby or if you are breastfeeding
- have diabetes (high blood sugar)
- use corticosteroid medications on a long-term basis
- have severe migraine headaches
Tell your doctor about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Estradiol-Tetragynon S >
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
- memory problems, confusion, unusual behavior;
- unusual vaginal bleeding, pelvic pain;
- a lump in your breast; or
- high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.
Common side effects may include:
- nausea, vomiting, bloating, stomach cramps;
- fluid retention (swelling, rapid weight gain);
- breast pain;
- redness or irritation where the patch was worn;
- thinning scalp hair; or
- vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tetragynon Brand Names
Tetragynon may be found in some form under the following brand names:
How should this medicine be used?
Tetragynon comes as a tablet to take by mouth. If you are taking Tetragynon as a single tablet product , take one tablet as soon as possible within 72 hours after unprotected sexual intercourse. If you are taking Tetragynon as a two tablet product, take one tablet as soon as possible within 72 hours after unprotected sexual intercourse and take a second dose 12 hours later. Tetragynon works best if it is taken as soon as possible after unprotected sexual intercourse. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Tetragynon exactly as directed.
If you vomit less than 2 hours after you take a dose of Tetragynon, call your doctor. You may need to take another dose of this medication.
Because you can become pregnant soon after treatment with Tetragynon, you should continue using your regular method of birth control or begin using regular birth control immediately.
Pharmacologic class: Contraceptive, intrauterine device (Mirena); oral contraceptive, progestin-only pill (Plan B)
Therapeutic class: Contraceptive
Pregnancy risk category X (Mirena), NR (Plan B)
Tetragynon is the biologically active form of norgestrel and is one of the most potent orally active progestins.
What Is Estradiol-Tetragynon?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. Tetragynon is a form of progesterone, a female hormone important for regulating ovulation and menstruation.
Estradiol and Tetragynon is a combination medicine used to treat menopause symptoms such as hot flashes, and to prevent osteoporosis (bone loss) in menopausal women.
Estradiol and Tetragynon may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have had a hysterectomy, or if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Estradiol and Tetragynon may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol and Tetragynon should not be used to prevent heart disease, stroke, or dementia.
You should not use this medicine if you are allergic to estradiol or Tetragynon, if you have had a hysterectomy, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a bleeding disorder;
- a history of heart attack, stroke, or blood clot; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol and Tetragynon if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estradiol and Tetragynon should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- hereditary angioedema (an immune system disorder);
- kidney disease;
- gallbladder disease;
- epilepsy or other seizure disorder;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
- endometriosis or uterine fibroid tumors;
- a thyroid disorder; or
- high levels of calcium in your blood.
Using estradiol may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estradiol and Tetragynon can slow breast milk production. Tell your doctor if you are breast-feeding.