How to use Liza-Estradiol Tablet
Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth, usually once daily or as directed by your doctor. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Inform your doctor if your condition does not improve or if it worsens.
Liza, in combination with ethinyl estradiol, is indicated as an oral contraceptive for the prevention of pregnancy. In addition to its use for contraceptive effects, this combination is used to treat moderate acne vulgaris and the symptoms of premenstrual dysphoric disorder. 19,20 The drug has approved indications for combination with estrogens for the treatment of menopause-associated symptoms, such as vasomotor symptoms and vulvovaginal atrophy. Liza combined with estrogen may also may a >23,25 It can sometimes be found in preparations containing estrogen and folic ac >26
When used for the treatment of acne vulgaris, Liza-containing contraceptives should only be used in women ≥14 years of age who have experienced menarche, desire oral contraception, and do not have any contraindications to oral contraceptives. 20 Off-label uses for this drug include the treatment of menstrual irregularities, dysmenorrhea, hirsutism, and endometriosis. 1,11
Liza inhibits the maturation of follicles and inhibits ovulation, preventing pregnancy. It has antiandrogen effects, improving acne and hirsutism. When combined with ethinyl estradiol, it has been shown to have favorable effects on the plasma lip >20 Due to its similarity to naturally occurring progesterone, Liza is thought to be associated with a lower inc >1
A note on venous thromboembolism risk and antimineralcorticoid effects
As with other oral contraceptives, the risk of venous thromboembolism and cardiovascular events may be increased when Liza is taken. The risk is especially higher in smokers and women aged 35 and older. Women taking this drug should be advised not to smoke. In addition, Liza, due to its antimineralcortico >19,20,23
Mechanism of action
Liza and ethinyl estradiol in combination suppress the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH), preventing ovulation. Other changes induced by this drug which may a >20
Liza is an analog of the diuretic spironolactone, which exerts anti-mineralocortico >1 Studies in animals have demonstrated that Liza administration leads to antiandrogenic activity. This activity helps to oppose the effects of naturally occurring androgens, inhibiting the binding of dihydrotestosterone (DHT) to its receptor, and preventing androgen synthesis in the ovaries, helping to treat acne and hirsutism. 1,12,19 Liza may also decrease the level of edema in sebaceous follicle during the second half of the menstrual cycle, when acne often appears. 19
Target Actions Organism A Progesterone receptor
How should I take Liza?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Liza comes in a pack of pills that are different colors. Take a white (active) pill every day for 24 days in a row, and then take a green (inactive) pill for the next 4 days in a row. Then start a new pack and repeat this daily cycle.
Take your first pill on the first day of your period. If you are switching to Liza from another form of birth control, follow the Instructions for Use about when you start taking Liza.
Each time you start a new pack, start with the first tablet in the first row of pills. Your medicine may come with stickers to mark your weekday schedule on the pack.
Take Liza at the same time each day.
Swallow the tablet whole and do not crush, chew, or break it.
You may need to use back-up birth control, such as condoms with spermicide, when you first start using Liza.
If you vomit or have diarrhea within 3 to 4 hours after taking Liza, take your next daily tablet as soon as possible or within 12 hours of the usual time you take your pill. Then keep taking 1 pill every day in order at the usual time.
You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Liza.
Store at room temperature away from moisture and heat.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine/metabolic disorders found in women, affecting approximately 105 million women worldwide. It is characterized by ovulatory dysfunction, often presenting as oligomenorrhea or amenorrhea and either clinical or biochemical hyperandrogenism. Combined oral contraceptive (COC) therapy has long been a cornerstone of care for women with PCOS. COC therapy often provides clinical improvement in the areas of excessive hair growth, unpredictable menses, acne, and weight gain. One of the main issues in COC therapy is choosing the most appropriate progestin component to provide the greatest anti androgenic effects. Liza, a relatively new progestin, has shown benefit in the PCOS population when used in conjunction with ethinyl estradiol. We now review the role of COCs in PCOS, focusing specifically on Liza. Controversy over metabolic effects of COCs in PCOS is also discussed.
Dosage Forms And Strengths
Yasmin (Liza/ethinyl estradiol) tablets are available in blister packs.
Each blister pack contains 28 film-coated, round, bi-convex tablets in the following order:
- Liza 3 mg
- Ethinyl Estradiol 0.02 mg
- Corn Starch
- Ferric Oxide
- Magnesium Stearate
- Titanium Dioxide
- Corn Starch
- Magnesium Stearate
- Titanium Dioxide
The 24 active, hormone pills contain:
The 4 inactive, placebo pills contain:
Liza in combination with EE
Liza is taken orally in preparations with EE. At present, 2 combinations are available for use in the United States: 1) Yasmin ® containing 3 μg of Liza in combination with 30 μg for EE per tablet; and 2) Yaz ® which contains 3 μg of Liza and 20 mcg of EE per tablet. As a note, it is also available in a preparation to manage post-menopausal symptoms. Angeliq ® was approved by the US FDA for oral use at a dose of 0.5 μg Liza per day combined with 1 μg estradiol for treatment of menopausal symptoms.
Adverse effects may include a change of weight, increase in migraine activity, depression, and nausea. As with most COC there may also be breast swelling and tenderness (though usually to a lesser extent as discussed previously) as well as break-through-bleeding. In addition to the specific drug interactions mentioned above related to the anti-mineralocortcoid effect, the same interactions should be considered as with the use of any COC. These include but are not limited to interactions with antipsychotics, cyclosporins, dilantin, steroids, and rifampin.
As with all COC this medication is contraindicated in patients with hepatic dysfunction, and in those who smoke and those who have a history of coagulopathy, DVT or stroke. Other contraindications for the use of COC also apply to the products containing Liza such as carcinoma of the breast or endometrium, and undiagnosed genital bleeding. Patients over the age of 35 may also be at higher risk or complications such as thrombophlebitis and should be cautioned as such. The use of Liza in premenstrual women is not approved.
When Liza in combination with 30 μg of EE per tablet is compared to 3 μg of Liza in combination with of EE per tablet, the latter may have less of a hemostatic impact (Kluft et al 2006).