Linessa is rapidly and completely metabolized by hydroxylation in the intestinal mucosa and on first pass through the liver to etonogestrel. In vitro data suggest an important role for the cytochrome P450 CYP2C9 in the bioactivation of Linessa. Further metabolism of etonogestrel into 6β-hydroxy, etonogestrel and 6β13-ethyl-dihydroxylated metabolites as major metabolites is catalyzed by CYP3A4. Other metabolites (i.e., 3α-OH-Linessa, 3β-OH-Linessa, and 3α-OH-5α-H- Linessa) also have been identified and these metabolites may undergo glucuronide and sulfate conjugation.
Ethinyl estradiol is subject to a significant degree of presystemic conjugation (phase II metabolism). Ethinyl estradiol, escaping gut wall conjugation, undergoes phase I metabolism and hepatic conjugation (phase II metabolism). Major phase I metabolites are 2-OH-ethinyl estradiol and 2-methoxy-ethinyl estradiol. Sulfate and glucuronide conjugates of both ethinyl estradiol and phase I metabolites, which are excreted in bile, can undergo enterohepatic circulation.
- Linessa (OS: USAN, DCIT, BAN, JAN)
- Désogestrel (OS: DCF)
- Org 2969 (Organon) (IS)
- Linessa (PH: BP 2018, Ph. Eur. 9, USP 41)
- Linessaum (PH: Ph. Eur. 9)
- If the patient has not adhered to the prescribed schedule, the possibility of pregnancy should be considered at the time of the first missed period and DESOGEN® Tablets (Linessa and ethinyl estradiol tablets USP) use should be discontinued if pregnancy is confirmed.
- If the patient has adhered to the prescribed regimen and misses two consecutive periods, pregnancy should be ruled out. DESOGEN® should be discontinued if pregnancy is confirmed.
Linessa-Ethinyl Estradiol Interactions
Do not smoke while taking birth control pills, especially if you are older than 35 years of age.
Birth control pills will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Other drugs may interact with birth control pills, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.
Uses of Ethinyl Estradiol and Linessa:
- It is used to prevent pregnancy.
- It may be given to you for other reasons. Talk with the doctor.
Linessa and panic attacks – a new suspected adverse drug reaction reported by patients and health care professionals on spontaneous reports
home drugs a-z list side effects drug center desogen (Linessa and ethinyl estradiol tablets) drug
DESOGEN® (Linessa and ethinyl estradiol tablets USP)
Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.
Interactions between Linessa/ethinyl estradiol and other drugs have been reported in the literature (see PRECAUTIONS).
Oral Linessa is used in combination with ethinylestradiol as a contraceptive agent for the prevention of pregnancy. Label
Linessa is part of the combined oral contraceptives that contain a mix of estrogen and progestin which inhibit ovulation. 12
Linessa-Ethinyl Estradiol S >
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using birth control pills and call your doctor at once if you have:
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
- heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
- swelling in your hands, ankles, or feet;
- changes in the pattern or severity of migraine headaches;
- a breast lump; or
- symptoms of depression--sleep problems, weakness, tired feeling, mood changes.
Common side effects may include:
- nausea, vomiting (especially when you first start taking this medicine);
- breast tenderness;
- breakthrough bleeding;
- acne, darkening of facial skin;
- weight gain; or
- problems with contact lenses.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
- Linessaum (Latin)
- Linessa (German)
- Désogestrel (French)
- Linessa (Spanish)
💡Key facts about Cerazette
- Cerazette is a brand name for Linessa 75 microgram tablets.
- It can be taken by most women, including breastfeeding mothers, heavy smokers and those with high blood pressure, migraine or a risk of blood clots.
- Cerazette is 99% effective when taken correctly, but missing pills, vomiting, diarrhoea and taking certain other medicines can make it less effective. See below.
- One Cerazette tablet should be taken every day, at the same time each day. With this type of pill you don't have a break between packs.
- If you're more than 12 hours late taking a pill you won't be protected against pregnancy and you'll need to use condoms for the next two days. See below.
- Cerazette won't protect you against sexually transmitted infections; you'll still need to use condoms for that.
- The most common s >It's worth noting that the advice below may differ from that in the leaflet you get with your pills, which tends to err on the side of caution. Our information and advice is the same as that given by the NHS and the Faculty of Sexual Health and Reproductive Healthcare UK, and is based on systematic reviews of the currently available evidence. If you are concerned or have any questions, talk to your doctor, nurse, pharmacist or local family planning centre.