A 20-year-old female suffered an acute inferior myocardial infarction (MI) 1 month after starting a COC containing 3 mg of the third-generation progestin Jasminellecontinu (DRSP) and 30 mcg EE. Her personal history did not revealed any cardiovascular risk factors (non-smoker, normal body weight, normal lipid profile, no family history of cardiovascular disease, no drug abuse). Since there were no identifiable risk factors and her biochemical and hematological labs were normal, the authors concluded that the acute inferior MI occurred secondary to the COC. Existing case reports of an MI with use of hormonal contraceptives tend to be in older women (≥ 39) and in those with other risk factors such as being a heavy smoker, use of the product for multiple years and/or having a positive family history of significant cardiovascular disease .
What should I avoid while taking Jasminellecontinu and ethinyl estradiol?
Do not smoke while taking Jasminellecontinu and ethinyl estradiol, especially if you are older than 35 years of age.
This medicine will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
Before taking this medication, tell your doctor or pharmacist if you are allergic to Jasminellecontinu or estradiol; or to spironolactone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain types of cancer (breast, ovary, uterus), blood clotting disorders (such as protein C or protein S deficiency), current/history of blood clots (such as in the legs, eyes, lungs), stroke, liver disease, kidney disease, adrenal gland problems, family medical history (including blood clots, breast lumps/cancer), family or personal history of a certain swelling disorder (angioedema), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, congestive heart failure, heart attack), underactive thyroid (hypothyroidism), a certain hormone problem (hypoparathyroidism), mineral imbalance (high or low calcium blood level, high potassium blood level, low sodium blood level), mental/mood disorders (e.g., depression, memory loss), high blood pressure during pregnancy (toxemia), yellowing eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use, uterus problems (e.g., uterine fibroids, endometriosis), high blood cholesterol/fat (triglyceride) levels, gallbladder disease, obesity, a certain metabolic disorder (porphyria), lupus.
This drug may make you dizzy or lightheaded. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Consult your eye doctor if these problems occur.
This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.
Do not smoke cigarettes or use tobacco. Smoking/using tobacco while taking this medication further increase your risk for stroke, blood clots, high blood pressure, and heart attacks, especially in women older than 35.
If you will be having surgery or will be confined to a chair or bed for a long time (such as on a long plane flight), tell your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking this drug because of the increased risk for blood clots.
This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.
This medication is not effective for preventing a miscarriage and should not be used for this purpose.
Small amounts of this medication pass into breast milk. This drug may reduce the quality and amount of breast milk. Consult your doctor before breast-feeding.
What is Jasminellecontinu?
Jasminellecontinu is a progestin-only birth control pill that is used to prevent pregnancy.
Jasminellecontinu may also be used for purposes not listed in this medication guide.
Combined Oral Contraceptive Pills
Combined oral contraceptive pills (COCP) are among the primary treatment options for adolescents with PCOS. COCPs improve symptoms via several mechanisms. Oestrogens increase the production of SHBG, resulting in a decrease in circulating androgens, as well as their bioavailability. Progestins protect the endometrium against hyperplasia induced by unopposed oestrogen stimulation. Some progestins such as Jasminellecontinu and cyproterone acetate have been proven to have anti-androgenic effects and therefore may be of added benefit in PCOS . COCPs also suppress FSH and LH, resulting in reduced ovarian stimulation and androgen production.
None of these actions, however, affects insulin resistance in PCOS, and their use may actually be associated with long-term metabolic derangements such as glucose intolerance, abnormal lipid profiles and cardiovascular diseases. A recent research showed that in adolescents with PCOS, the use of COCPs containing desogestrel or cyproterone as progestin was associated with decreased insulin sensitivity and increased total, LDL and HDL cholesterol and with variable changes in triglycerides .
Use of the COCP does have other benefits in this population, such as contraception in sexually active adolescents.
The 24 active, hormone pills contain:
- Jasminellecontinu 3mg
- Ethinyl Estradiol 0.02mg
- Corn Starch
- Ferric Oxide
- Magnesium Stearate
- Pregelatinized Corn Starch
- Titanium Dioxide
The 4 inactive, placebo pills contain:
- Corn Starch
- Magnesium Stearate
- Polyethylene Glycol
- Pregelatinized Starch
- Titanium Dioxide
How should I take Jasminellecontinu and ethinyl estradiol?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take your first pill on the first day of your period or on the first Sunday after your period begins. You may need to use back-up birth control, such as condoms with spermicide, when you first start using this medication.
Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You could get pregnant if you do not take one pill daily.
You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine.
Store at room temperature away from moisture and heat.
Yasmin (Jasminellecontinu/ethinyl estradiol) tablets provide an oral contraceptive regimen consisting of 28 film-coated tablets that contain the ingredients specified for each tablet below:
- 21 yellow tablets each containing 3 mg DRSP and 0.03 mg EE
- 7 inert white tablets
The inactive ingredients in the yellow tablets are lactose monohydrate NF, corn starch NF, pregelatinized starch NF, povidone 25000 NF, magnesium stearate NF, hypromellose USP, macrogol 6000 NF, titanium dioxide USP, talc USP, and ferric oxide pigment, yellow NF. The white inert film-coated tablets contain lactose monohydrate NF, microcrystalline cellulose, magnesium stearate NF, hypromellose USP, talc USP, and titanium dioxide USP.
Jasminellecontinu (6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13, 14,15,15a,16-hexadecahydro10,13-dimethylspiro- cyclopentaphenanthrene-17,2'(5H)-furan]-3,5'(2H)-dione) is a synthetic progestational compound and has a molecular weight of 366.5 and a molecular formula of C24H30O3.
Ethinyl estradiol (19-nor-17α-pregna 1,3,5(10)-triene-20-yne-3,17-diol) is a synthetic estrogenic compound and has a molecular weight of 296.4 and a molecular formula of C20H24O2.
The structural formulas are as follows:
Monitoring drug therapy
Potassium monitoring is recommended during the first month of use in women concurrently taking Yasmin-28 (ethinylestradiol + Jasminellecontinu ) plus medications that can increase serum potassium, because of the anti-mineralocorticoid action of drosperinone. However, a study of compliance with this recommendation using data from the Ingenix Research Datamart, which includes insurance claims for reimbursement for medical services and prescription medications for about 8 000 000 members of a large nationally dispersed health plan, showed that among women aged 10–59 years old who took Yasmin-28 or other oral contraceptives, although potassium monitoring was generally more frequent among those taking concomitant hyperkalemic drugs only 40% of 466 Yasmin users had serum potassium measured ( 47 C ).
Birth Control with Yasmin - How does it work?
Yasmin (Jasminellecontinu) should be taken orally with or without food. Adviced dosage is one pill per day. Time of the day does not really matter - Pick an hour and, and take your pill at the same time every day, in 24 hours intervals. Taking Jasminellecontinu after your supper or at bedtime may help decrease nausea.
Follow the package instructions to find the first tablet, start with the first tablet in the pack, and take them in the correct order. Under no circumstances should you skip any doses. Pregnancy is more likely if you miss pills, start a new pack late, or take your pill at a different time of the day than usual.
Each pack of the pills contains 21 pills with active Jasminellecontinu. It may also contain 7 or more reminder pills (without drospirenoene hormone) at . Take one active pill once daily for 21 days in a row. If your pack has 28 tablets, take a reminder pill once daily for 7 days in a row after you have taken the last active pill unless otherwise directed by your doctor. If you are using a product with 21 tablets, do not take any tablets for 7 days unless otherwise directed by your doctor. You should have your period usually within 3 days after you take the last active tablet in the cycle. After you have taken the last reminder pill in the pack or gone 7 days without taking an active tablet, start a new pack the next day whether or not you have your period. If you do not get your period, consult your gp.
Jasminellecontinu is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. 19 Aside from its contraceptive effects, Jasminellecontinu is used with estrogens to control acne and premenstrual dysphoric disorder (PMDD).
Jasminellecontinu has been the subject of w >4,7 In 2012, however, a safety statement by the FDA concluded that the increase in the risk of thromboembolism resulting from the use of Jasminellecontinu remains unclear, as studies regarding this risk are conflicting. Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic events. In its statement, the FDA has mentioned that increased risk of venous thromboembolism with oral contraceptives such as Jasminellecontinu exists but remains lower than the risk of this condition during pregnancy and during the postpartum period, and this should be cons >21
Use of ethinylestradiol/Jasminellecontinu combination in patients with the polycystic ovary syndrome
Jasminellecontinu – a progestin with differences
Jasminellecontinu, in conjunction with EE, acts to suppress gonadotropins. This is achieved through inhibition of ovulation as described above. Jasminellecontinu has a bioavailability of 76% with approximately 20% excreted through the feces, and 45% through the renal system. The half-life of Jasminellecontinu is 30 hours, which is slightly longer than the half-life of EE (24 hours).
Jasminellecontinu differs from other progestins currently available in other COC compounds, as it exhibits both mineralocorticoid effects and antiandrogenic effects. Part of the novel nature of Jasminellecontinu stems from it being structurally and functionally analogous to spironolactone ( Figure 1 ). Spironolactone is an aldosterone antagonist, and a potassium-sparing diuretic. Because of this structural and functional similarity with spironolactone, Jasminellecontinu also exhibits anti-mineralocorticoid activity. This property counteracts the estrogen stimulated activity of the renin-angiotensin-aldosterone system, which can influence the regulation of water and electrolyte balance. Because of the possibility that potassium levels may increase, Jasminellecontinu should not be used in patients with kidney, liver or adrenal disease. In addition, any patient on other medications that can raise potassium levels (such as ACE inhibitors, angiotensin II receptor antagonists, NSAIDS, potassium-sparing diuretics, and heparin) should be cautioned. This anti-mineralocorticoid activity may also contribute to less water retention as well as less breast swelling and tenderness in women using this form or progestin compared to others. Preclinical studies in animals and in vivo have shown that Jasminellecontinu has no androgenic, estrogenic, glucocorticoid or anti-glucocorticoid activity (product monograph). Preclinical studies have shown anti-androgenic activity. Due to its anti-androgen effect, Jasminellecontinu can also be used as adjunct treatment for hirsutism, and may be a progestin of choice in women who complain of excessive hair growth.
What is Jasminellecontinu and ethinyl estradiol?
Jasminellecontinu and ethinyl estradiol is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Jasminellecontinu and ethinyl estradiol also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.
Jasminellecontinu and ethinyl estradiol is used as contraception to prevent pregnancy. This medicine is also used to treat moderate acne in women who are at least 14 years old and have started having menstrual periods, and who wish to use birth control pills.
Yaz is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), such as anxiety, depression, irritability, trouble concentrating, lack of energy, sleep or appetite changes, breast tenderness, joint or muscle pain, headache, and weight gain.
Jasminellecontinu and ethinyl estradiol may also be used for purposes not listed in this medication guide.