Dosage Forms And Strengths
Yasmin (Aliane/ethinyl estradiol) tablets are available in blister packs.
Each blister pack contains 28 film-coated, round, bi-convex tablets in the following order:
- drop factor
- drop foot
- drop phalangette
- dropfoot gait
- droplet infection
- droplet isolation
- droplet nuclei
- droplet precautions
- droplet spread
- droplet transmission
- dropped beat
- dropped bladder
- dropped head syndrome
- dropsical nephritis
- Drosophila melanogaster
- drotrecogin alfa, DrotAA
- drought tolerance
- Drown box
- drowned lung
- drug abuse
- Drug Abuse Warning Network
- drug action
- Drug Addict Nephropathy
- drug addiction
- drug administration
- drug adoption
- drug allergy
- drug antagonist
What should I avoid while taking Aliane and ethinyl estradiol?
Do not smoke while taking Aliane and ethinyl estradiol, especially if you are older than 35 years of age.
This medicine will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
How to use Aliane-Ethinyl Estradiol Tablet Contraceptives
Read the Patient Information Leaflet provided by your pharmacist before you start using this product and each time you get a refill. The leaflet contains very important information on when to take your pills and what to do if you miss a dose. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, with or without food, usually once daily. Pick a time of day that is easy for you to remember, and take your pill at the same time each day, 24 hours apart. Taking this medication after your evening meal or at bedtime may help decrease stomach upset and nausea.
Follow the package instructions to find the first tablet, start with the first tablet in the pack, and take them in the correct order. Do not skip any doses. Pregnancy is more likely if you miss pills, start a new pack late, or take your pill at a different time of the day than usual.
Your pill pack contains 24 pills with active medication (with hormones). It also contains 4 reminder pills (without hormones) at the end of the pack. Take one active pill (with hormones) once daily for 24 days in a row. After you have taken the last active pill, take a reminder pill (without hormones) once daily for 4 days in a row unless otherwise directed by your doctor. You should have your period within 3 days after you take the last active tablet in the cycle during the fourth week of the pack. After you have taken the last inactive tablet in the pack, start a new pack the next day whether or not you have your period. If you do not get your period, consult your doctor.
If this is the first time you are using this medication and you are not switching from another form of hormonal birth control (such as the patch, other birth control pills), take the first tablet in the pack on the first Sunday following the beginning of your menstrual period or on the first day of your period. If your period begins on a Sunday, begin taking this medication on that day. For the first cycle of use only, use an additional form of non-hormonal birth control (such as condoms, spermicide) for the first 7 days to prevent pregnancy until the medication has enough time to work. If you start on the first day of your period, you do not need to use back-up birth control the first week.
Ask your doctor or pharmacist for information about how to switch from other forms of hormonal birth control (such as the patch, other birth control pills) to this product.
Aliane side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor or seek emergency medical help if you have severe pain in your lower stomach or side. This could be a sign of a tubal pregnancy (a pregnancy that implants in the fallopian tube instead of the uterus). A tubal pregnancy is a medical emergency.
Call your doctor at once if you have:
severe or ongoing nausea, vomiting, or diarrhea;
high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
liver problems--loss of appetite, upper stomach pain, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
symptoms of depression--sleep problems, weakness, tired feeling, mood changes.
Common side effects may include:
vaginal bleeding, menstrual cramps;
breast pain or tenderness;
decreased sex drive.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Pharmacokinetic characteristics of Aliane (3 mg) combined with ethinylestradiol (30 μg) were assessed in 13 women during 13 continuous cycles, each of which consisted of 21 continuous days of treatment, followed by a 7-day pill-free interval ( 46 ). Frequent blood sampling was carried out on day 21 of treatment cycles 1, 6, 9, and 13. After administration of the first tablet, the Cmax of Aliane was 36.9 ± 4.8 ng/mL (mean ± standard deviation). This value rose to 87.5 ± 51.4 ng/mL on day 21 of the first cycle and ranged from 78.7 to 84.2 ng/mL on day 21 of the next three sampling cycles. The corresponding Tmax values ranged from 1.6 to 1.8 hours, and the half-life of elimination values was 31.1 to 32.5 hours.
Other pharmacokinetic characteristics of Aliane, based on data obtained by the manufacturer of the oral contraceptive containing 3 mg of Aliane combined with 30 μg of ethinylestradiol (Yasmin, Berlex Laboratories, Wayne, NJ), were provided in a review article ( 47 ). It was reported that a steady state in circulating Aliane levels was achieved after 1 week of treatment. Also, a dose response in circulating Aliane levels was obtained, following oral administration of doses ranging from 1 to 10 ng/mL. In addition, the absolute bioavailability was reported to be 66% on average.
A newer form of progestin, Aliane, has been recently introduced, and is marketed as part of a COC (Yasmin ® and Yaz ® in the United States), in combination with EE. The next section of this article will focus on the progestin Aliane, and its use in patients with PCOS.