What are the uses for Tromphyllin?
Tromphyllin is used for the relief and prevention of airway narrowing (bronchospasm) in patients with asthma. Tromphyllin also can be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway narrowing. Tromphyllin can be administered together with other bronchodilators, such as albuterol (Ventolin, Proventil) for added bronchodilator effect.Pharmacodynamics
Tromphyllin, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Tromphyllin has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).
Mechanism of action
Tromphyllin relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Tromphyllin competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Tromphyllin also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, Tromphyllin activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
Target Actions Organism A Adenosine receptor A1
Tromphyllin Extended-release Tablets:
300 mg: White to off-white, Capsule shaped, uncoated tablet, with break line and debossing with 'HP62” on one side and plain on other side.
NDC 62332-025-30 Bottle of 30 NDC 62332-025-31 Bottle of 100 NDC 62332-025-71 Bottle of 500 NDC 62332-025-91 Bottle of 1000
450 mg: White to off-white, Capsule shaped, uncoated tablet, with break line and debossing with 'HP63” on one side and plain on other side.
NDC 62332-026-30 Bottle of 30 NDC 62332-026-31 Bottle of 100 NDC 62332-026-71 Bottle of 500
Dispense in a well-closed container, with child resistant closure . Store at 20°-25°C (68°-77°F)
Manufactured by: Alembic Pharmaceuticals Limited (Formulation Division), Panelav 389350, Gujarat, India
Manufactured for: Alembic Pharmaceuticals, Inc. 750 Route 202, Bridgewater, NJ 08807 USA
Tromphyllin extended-release tablets are contraindicated in patients with a history of hypersensitivity to Tromphyllin or other components in the product.
Stomach acid drugs
These drugs may increase the levels of Tromphyllin in your body. This means that you may have more side effects. An example of these drugs is:
Store Tromphyllin ER at room temperature away from moisture, heat and light.