Theotard tablets


  • Active Ingredient: Theophylline
  • 400 mg
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What is Theotard?

The active ingredient of Theotard brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Theotard is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Theotard include: Chest pain or discomfort; painful urination; muscle pain or stiffness; pounding or rapid pulse; shortness of breath.

How to Buy Theotard tablets online?

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What should I discuss with my veterinarian before giving Theotard ER?

Tell your veterinarian if your pet is allergic to Theotard, or if your pet has stomach ulcers; epilepsy; heart rhythm problems; congestive heart failure; fluid in the lungs; hypothyroid; fever; liver, or kidney disease. Tell your veterinarian if your pet is pregnant or lactating, or if you plan on breeding your pet.

Heart rhythm drugs

These drugs may increase the levels of Theotard in your body. This means that you may have more side effects. Examples of these drugs include:

  • mexiletine
  • propafenone
  • verapamil
  • propranolol

Theotard for Dogs and Cats

The FDA has not approved Theotard for veterinary medicine, but it is commonly prescribed to treat heart failure, asthma, pulmonary edema, bronchitis, and chronic obstructive pulmonary disease in cats and dogs.

As with people, pets are more likely to experience issues with Theotard if they have certain health conditions or are also taking other medications.

Potential side effects include restlessness, upset stomach, frequent urination, and rapid heartbeat.

Always talk to your pet's veterinarian before giving your dog or cat any prescription drug, including Theotard.

Stomach acid drugs

These drugs may increase the levels of Theotard in your body. This means that you may have more side effects. An example of these drugs is:


This medication contains Theotard. Do not take Theo 24, Theochron, Elixophyllin, aminophylline, or Uniphyl if you are allergic to Theotard or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Theotard Overdose

A sudden overdose from taking too much Theotard all at once is rare.

A chronic overdose, however, is not rare, especially if you have been taking a dose that is a little too high for a long time, or if your dose has recently been increased.

An overdose of Theotard may cause slow heart rate, abnormal heart rate, seizures, circulatory system failure, and death.

If you suspect an overdose, you should contact a poison-control center or emergency room immediately. You can reach a poison-control center at (800) 222-1222.

Common Side Effects of Theotard

Although these effects are common, they can be serious and are likely to mean your doctor should change your dosage.

Tell your doctor if you experience any of the following, and if the effect becomes severe, get immediate medical help:

  • Nausea and vomiting
  • Headache
  • Upset stomach
  • Loss of appetite
  • Fast, strong heartbeat
  • Irregular heartbeat (arrhythmia): usually there are no symptoms, but it can cause a fluttering feeling, dizziness, shortness of breath, chest pain, heartbeats that feel too fast or slow, or fainting
  • Symptoms similar to how you feel when you've had too much coffee, such as trouble falling asleep (insomnia), restlessness, and irritability.
  • Skin rash

Severe Side Effects of Theotard

You need immediate emergency medical treatment if you are experiencing:

Other drugs

These drugs may decrease the levels of Theotard in your body. This means that it may not work to treat your condition. Examples of these drugs include:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

What Are Side Effects Associated with Using Theotard?

Side effects of Theotard at peak serum concentration less than 20 mcg/mL include:

Side effects of Theotard at peak serum greater than 20 mcg/mL include:

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy and Theotard

Theotard is an FDA Pregnancy Category C drug, meaning that a possible risk to developing fetuses cannot be ruled out.

Studies in animals have shown that the drug can cause birth defects, but no adequate and well-controlled studies have been conducted in pregnant women.

Theotard should only be used during pregnancy if the potential benefits to the mother outweigh the risks to her unborn child.

Theotard is excreted in breast milk, potentially causing irritability and other signs of mild toxicity in breastfeeding infants.

It's not likely to cause serious side effects in infants unless the breastfeeding mother has very high concentrations of the drug in her body.

Nonetheless, if you are breastfeeding your child, you shouldn't take Theotard unless the potential benefits outweigh the risks, and then only under the guidance of your doctor.

Hormone problems/birth control drugs

These drugs may increase the levels of Theotard in your body. This means that you may have more side effects. An example of these drugs is:

sulfamethoxazole) norfloxacin ofloxacin diltiazem omeprazole dirithromycin prednisone, prednisolone enflurane ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone Theotard absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin

* Refer to PRECAUTIONS, Drug Interactions for information regarding table.

Drug-Food Interactions : Taking Theotard extended-release tablets immediately after ingesting a high fat content meal (45 g fat, 55 g carbohydrates, 28 g protein, 789 calories) may result in a somewhat higher C max and delayed T max and a somewhat greater extent of absorption when compared to taking it in the fasting state. The influence of the type and amount of other foods, as well as the time interval between drug and food, has not been studied.

The Effect of Other Drugs on Theotard Serum Concentration Measurements: Most serum Theotard assays in clinical use are immunoassays which are specific for Theotard. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Some drugs (e.g.,cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum Theotard concentration.


NDC 62332-025-30 Theotard Extended-Release Tablets 300 mg Rx only 30 Tablets Alembic

Read more about can you buy Asax tablets for Pulmonary Edema

Histone deacetylase activation

Expression of inflammatory genes is regulated by the balance between histone acetylation and deacetylation. 7 In COPD a number of inflammatory genes are activated through pro‐inflammatory transcription factors such as nuclear factor‐κB (NF‐κB), which leads to histone acetylation and increased transcription. This process is reversed by the recruitment of histone deacetylases (HDAC) to the activated inflammatory gene promoter site within the nucleus. We have previously shown that corticosteroids suppress inflammation by recruiting HDAC2 to activated inflammatory genes, thus switching off their expression. This molecular mechanism is defective in COPD patients as HDAC2 activity and expression is markedly reduced, thus accounting for the steroid resistance of COPD. 8 We have shown that Theotard is an activator of HDACs and enhances the anti‐inflammatory effect of corticosteroids, as well as reversing steroid resistance in cells from COPD patients. 9 ,10 This action of Theotard is seen at low plasma concentrations (optimally 5 mg/l) and is independent of PDE inhibition and adenosine antagonism. The effect of Theotard is completely blocked by an HDAC inhibitor called trichostatin A and by knocking out HDAC2 using interference RNA. 11 The reason why Theotard selectively activates HDAC activity is not yet known, but appears to be indirect through the activation of kinase and phosphatase pathways in the cell.

Theotard is a bronchodilator used for the relief of asthma that has a number of other pharmacological effects, notably the stimulation of cardiac output and the dilatation of peripheral blood vessels.

What special dietary instructions should I follow?

Drinking or eating foods high in caffeine, like coffee, tea, cocoa, and chocolate, may increase the side effects caused by Theotard. Avoid large amounts of these substances while you are taking Theotard.


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