Theodur tablets

Theodur

  • Active Ingredient: Theophylline
  • 400 mg
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What is Theodur?

The active ingredient of Theodur brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Theodur is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Theodur include: mood changes; trouble sleeping; irritability; decreased urine; painful urination; loss of appetite; dry mouth; unable to sleep.

How to Buy Theodur tablets online?

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Carcinogenesis, Mutagenesis, Impairment of Fertility:

Long-term carcinogenicity studies have been carried out in mice (oral doses 30-150 mg/kg) and rats (oral doses 5-75 mg/kg). Results are pending.

Theodur has been studied in Ames salmonella, in vivo and in vitro cytogenetics, micronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic.

In a 14 week continuous breeding study, Theodur, administered to mating pairs of B6C3F 1 mice at oral doses of 120, 270 and 500 mg/kg (approximately 1.0-3.0 times the human dose on a mg/m² basis) impaired fertility, as ev >1 mice at oral doses of 40-300 mg/kg (approximately 2.0 times the human dose on a mg/m² basis). At the high dose, systemic toxicity was observed in both species including decreases in testicular weight.

What are the potential side effects of Theodur ER?

If any of the following serious side effects occur, stop giving Theodur ER and seek emergency veterinary medical attention: an allergic reaction such as difficulty breathing, swelling of the lips, tongue, face, or hives. Stop giving Theodur and call your veterinarian at once if any of the following side effects occur: seizures, severe nausea and vomiting, and restlessness, coughing up blood or vomit that looks like coffee grounds, urinating more than normal. Other less serious side effects may also occur. Talk to your veterinarian if your pet experiences mild nausea, loss of appetite, weight loss, restlessness, insomnia, headache, or dizziness. Side effects other than those listed here may also occur. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to your pet.

Seizure drugs

These drugs may decrease the levels of Theodur in your body. This means that it may not work to treat your condition. Examples of these drugs include:

General:

Careful cons >WARNINGS ). The dose of Theodur selected for initiation of therapy should be low and, if tolerated , increased slowly over a period of a week or longer with the final dose gu >DOSAGE AND ADMINISTRATION, Table V ).

Monitoring Serum Theodur Concentrations: Serum Theodur concentration measurements are readily available and should be used to determine whether the dosage is appropriate. Specifically, the serum Theodur concentration should be measured as follows: 1. When initiating therapy to guide final dosage adjustment after titration. 2. Before making a dose increase to determine whether the serum concentration is sub-therapeutic in a patient who continues to be symptomatic. 3. Whenever signs or symptoms of Theodur toxicity are present. 4. Whenever there is a new illness, worsening of a chronic illness or a change in the patient's treatment regimen that may alter Theodur clearance (e.g., fever >102°F sustained for ≥24 hours, hepatitis, or drugs listed in Table II are added or discontinued).

To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum Theodur concentration; 12 hours after an evening dose or 9 hours after a morning dose at steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. A trough concentration (i.e., at the end of the dosing interval) provides no additional useful information and may lead to an inappropriate dose increase since the peak serum Theodur concentration with an immediate-release formulation. If the serum sample is drawn more than 12 hours after the evening dose, or more than 9 hours after a morning dose, the results must be interpreted with caution since the concentration may not be reflective of the peak concentration. In contrast, when signs or symptoms of Theodur toxicity are present, a serum sample should be obtained as soon as possible, analyzed immediately, and the result reported to the healthcare professional without delay. In patients in whom decreased serum protein binding is suspected (e.g., cirrhosis, women during the third trimester of pregnancy), the concentration of unbound Theodur should be measured and the dosage adjusted to achieve an unbound concentration of 6-12 mcg/mL.

Saliva concentrations of Theodur cannot be used reliably to adjust dosage without special techniques.

Summary

Theodur (Elixophyllin, Theo-24) is a bronchodilator prescribed for the treatment of asthma and other airway conditions. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.

Indications and dosages

➣ Acute bronchospasm in patients not receiving Theodur

Adults (otherwise healthy nonsmokers): Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 3 mg/kg P.O. q 6 hours for two doses, then a maintenance dosage of 3 mg/kg P.O. q 8 hours

Children ages 9 to 16; young adult smokers: Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 3 mg/kg P.O. q 4 hours for three doses, then a maintenance dosage of 3 mg/kg P.O. q 6 hours

Children ages 1 to 9: Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 4 mg/kg P.O. q 4 hours for three doses, then a maintenance dosage of 4 mg/kg P.O. q 6 hours

➣ Acute bronchospasm in patients receiving Theodur

Theodur Dosage

Your doctor may start you on a low dose of Theodur then gradually increase it while monitoring your symptoms and blood levels for the drug.

Theodur (Uniphyl and Theo-24) comes as controlled-release tablets, which are generally taken once a day with food or within one to two hours of mealtime.

Theodur also can be taken multiple times per day in an oral solution form.

Tablets must be swallowed whole. You must not chew, split, or crush them.

Severe Side Effects of Theodur

You need immediate emergency medical treatment if you are experiencing:

home drugs a-z list Theo-24(Theodur Anhydrous Capsule) side effects drug center

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Theo-24 (Theodur, anhydrous) is a bronchodilator used to treat the symptoms of asthma, bronchitis, and emphysema. Common side effects of Theo-24 include mild nausea, loss of appetite, stomach pain, diarrhea, upset stomach, weight loss, restlessness, tremor, sleep problems (insomnia), headache, lightheadedness, dizziness, sweating, restlessness, nervousness, or irritability.

Theo-24 is taken once daily, in doses ranging from 100 mg to 400 mg. Theo-24 may interact with carbamazepine, cimetidine, enoxacin, ephedrine or similar medications found in cold medicine or diet pills, erythromycin, fluvoxamine, propranolol, rifampin, St. John's wort, or thiabendazole. Tell your doctor all medications and supplements you use. During pregnancy, Theo-24 should be taken only if prescribed. It may be harmful to a fetus. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Theo-24 (Theodur, anhydrous) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gout drugs

These drugs may increase the levels of Theodur in your body. This means that you may have more side effects. An example of these drugs is:

What is Theodur ER?

Theodur ER (Extended-release) is a bronchodilator used to open air passages in the lungs. It relaxes muscles in the lungs and chest. Theodur is used in the treatment of heart failure, asthma, bronchitis, and pulmonary edema. Theodur ER may also be used for purposes other than those listed here. Theodur ER is sold per tablet and requires a prescription from your veterinarian.

WARNINGS:

Concurrent Illness: Theodur should be used with extreme caution in patients with the following clinical conditions due to the increased risk of exacerbation of the concurrent condition:

Active peptic ulcer disease Seizure disorders Cardiac arrhythmias (not including bradyarrhythmias) Conditions that Reduce Theodur Clearance: There are several readily > If the total daily dose is not appropriately reduced in the presence of these risk factors, severe and potentially fatal Theodur toxicity can occur. Careful cons >

Age: Neonates (term and premature), Children 60 years)

Concurrent Diseases: Acute pulmonary edema, congestive heart failure, cor-pulmonale, fever (≥102° for 24 hours or more; or lesser temperature elevations for longer periods), reduced renal function in infants

Cessation of Smoking Drug Interactions: Adding a drug that inhibits Theodur metabolism (e.g., cimet >PRECAUTIONS, Drug Interactions, Table II ).

When Signs or Symptoms of Theodur Toxicity Are Present: Whenever a patient receiving Theodur develops nausea or vomiting, particularly repetitive vomiting, or other signs or symptoms consistent with Theodur toxicity (even if another cause may be suspected), additional doses of Theodur should be withheld and a serum Theodur concentration measured immediately. Patients should be instructed not to continue any dosage that causes adverse effects and to withhold subsequent doses until the symptoms have resolved, at which time the healthcare professional may instruct the patient to resume the drug at a lower dosage (see DOSAGEAND ADMINISTRATION, Dosing Guidelines, Table VI ). Dosage Increases: Increases in the dose of Theodur should not be made in response to an acute exacerbation of symptoms of chronic lung disease since Theodur prov >2 -selective agonists and systemically administered cortico-stero >peak steady-state serum Theodur concentration should be measured before increasing the dose in response to persistent chronic symptoms to ascertain whether an increase in dose is safe. Before increasing the Theodur dose on the basis of a low serum concentration, the healthcare professional should cons >PRECAUTIONS, Laboratory Tests ). As the rate of Theodur clearance may be dose-dependent (i.e., steady-state serum concentrations may increase disproportionately to the increase in dose), an increase in dose based upon a sub-therapeutic serum concentration measurement should be conservative. In general, limiting dose increases to about 25% of the previous total daily dose will reduce the risk of unintended excessive increases in serum Theodur concentration (see DOSAGE AND ADMINISTRATION, Table VI ).

How does Theodur ER work?

Theodur ER opens air passages in the lungs by relaxing muscles in the lungs and chest.


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