Theodrip tablets

Theodrip

  • Active Ingredient: Theophylline
  • 400 mg
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What is Theodrip?

The active ingredient of Theodrip brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Theodrip is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Theodrip include: confusion; muscle cramps or spasms; increased thirst; unusual tiredness or weakness; shakiness; decreased urine; diarrhea; seizures.

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More common side effects

Some of the more common side effects that can occur with use of Theodrip include:

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Dosage Considerations – Should be Given as Follows:

  • Patients not currently taking Theodrip: 5-7 mg/kg intravenously/orally; not to exceed 25 mg/min intravenously (IV)
  • Aminophylline: 6-7 mg/kg intravenously/orally; IV infused over 20 minutes

  • 0.4-0.6 mg/kg/hour intravenously (IV) or 4.8-7.2 mg/kg orally (extended release) every 12 hours to maintain levels 10-15 mg/L
  • Smokers: 0.79 mg/kg/hour IV for next 12 hours after loading dose, then 0.63 mg/kg/hour or 5 mg/kg orally (extended release) every 8 hours
  • Coadmininstration with drugs that decrease Theodrip clearance (e.g., cimetidine, ciprofloxacin, and erythromycin and other macrolides): 0.2-0.3 mg/kg/hour IV or orally (extended release) every 12-24 hours
  • Congestive heart failure: 0.39 mg/kg/hour IV for next 12 hours after loading dose, then 0.08-0.16 mg/kg/hour
  • Aminophylline: 3.125 mg/kg orally every 6 hours

  • No Theodrip administered in previous 24 hours: 5-7 mg/kg intravenously/orally; IV infused over 20-30 minutes

  • 1.5-6 months: 0.5 mg/kg/ hour intravenously (IV) or 10 mg/kg/day orally in divided doses
  • 6-12 months: 0.6-0.7 mg/kg/ hour IV or 12-18 mg/kg/day orally in divided doses
  • 1-9 years: 1 mg/kg/ hour IV or 8 mg/kg orally (extended release) every 8 hours
  • 9-12 years: 0.8-0.9 mg/kg/ hour IV or 6.4 mg/kg orally (extended release) every 8 hours
  • 12-16 years: 0.7 mg/kg/ hour IV or 5.6 mg/kg orally (extended release) every 8 hours

  • Loading: 4-5 mg/kg orally/intravenously (IV) once
  • Maintenance: 3-6 mg/kg/day orally/IV divided every 8 hours
  • Dosing Considerations
  • If administering aminophylline, increase dose by 25% (aminophylline is approximately 79-86% Theodrip)
  • For oral loading, use immediate-release Theodrip or aminophylline
  • If patient is already taking Theodrip, give smaller loading dose
  • Use ideal body weight to calculate dose
  • 1 mg/kg results in 2 mg/L (34.4 mmol/L) increase in serum Theodrip
  • Therapeuticrange: 10-20 mg/L (172-344 mmol/L)

  • Hepatic impairment: After loading dose, 0.39 mg/kg/hour intravenously (IV) for next 12 hours, then 0.08-0.16 mg/kg/hour

Theodrip side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe or continued vomiting;

ongoing headache, trouble sleeping;

new signs of illness (especially fever);

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor.

Serious side effects may be more likely in older adults.

Common side effects may include:

feeling restless or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Generic Name: Theodrip (oral) (thee OFF i lin)Brand Name: Elixophyllin, Theo-24, . show all 34 brand names Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear L.A.-130, Aerolate JR, Theolair-SR, Theoclear L.A.-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Medically reviewed by Drugs.com on Sep 10, 2019 – Written by Cerner Multum

CONTRAINDICATIONS:

Theodrip extended-release tablets are contraindicated in patients with a history of hypersensitivity to Theodrip or other components in the product.

Theodrip for Dogs and Cats

The FDA has not approved Theodrip for veterinary medicine, but it is commonly prescribed to treat heart failure, asthma, pulmonary edema, bronchitis, and chronic obstructive pulmonary disease in cats and dogs.

As with people, pets are more likely to experience issues with Theodrip if they have certain health conditions or are also taking other medications.

Potential side effects include restlessness, upset stomach, frequent urination, and rapid heartbeat.

Always talk to your pet's veterinarian before giving your dog or cat any prescription drug, including Theodrip.

* These data are derived from two studies in patients with serum Theodrip concentrations >30 mcg/mL. In the first study (Study #1 - Shanon, Ann Intern Med 1993; 119:1161-67), data were prospectively collected from 249 consecutive cases of Theodrip toxicity referred to a regional poison center for consultation. In the second study (Study #2 - Sessler, Am J Med 1990;88:567-76), data were retrospectively collected from 116 cases with serum Theodrip concentrations >30 mcg/mL among 6000 blood samples obtained for measurement of serum Theodrip concentrations in three emergency departments. Differences in the incidence of manifestations of Theodrip toxicity between the two studies may reflect sample selection as a result of study design (e.g., in Study #1, 48% of the patients had acute intoxications versus only 10% in Study #2) and different methods of reporting results.

** NR = Not reported in a comparable manner.

What other drugs will affect Theodrip?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

If you take St. John's wort regularly, do not stop taking it without first asking your doctor. Starting or stopping St. John's wort can affect your blood levels of Theodrip.

Many drugs can affect Theodrip. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Dosage for asthma or other lung diseases

Adult dosage (ages 18–59 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of Theodrip in your blood.

Child dosage (ages 16–17 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of Theodrip in your blood.

Child dosage (ages 1–15 years who weigh more than 45 kg)

The starting dose is 300–400 mg per day. After 3 days, your doctor may increase your dose to 400–600 mg per day. After 3 more days, your dose may be adjusted as needed based on the level of Theodrip in your blood.

Child dosage (ages 1–15 years who weigh less than 45 kg)

The starting dose is 12–14 mg/kg per day up to 300 mg per day. After 3 days, your doctor may increase your dose to 16 mg/kg daily up to a maximum of 400 mg per day if you don’t have any side effects. After 3 more days, if the dose is tolerated, it may be increased to 20 mg/kg daily up to a maximum of 600 mg per day.

This drug is given in divided doses every 4–6 hours. Your dose will be adjusted based on the amount of Theodrip in the blood.

Child dosage (babies born at full-term up to 12 months of age)

Your doctor will calculate your child’s dose based on their age and body weight. The dose will be adjusted based on the amount of Theodrip in the blood.

  • For infants 0–25 weeks: The total daily dose should be divided into 3 equal doses taken by mouth every 8 hours.
  • For infants 26 weeks of age and older: The total daily dose should be divided into 4 equal doses taken by mouth every 6 hours.

Child dosage (babies born prematurely less than 12 months old)

  • Babies younger than 24 days: 1 mg/kg of body weight
  • Babies 24 days and older: 1.5 mg/kg of body weight

Senior dosage (ages 60 years and older)

  • The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.
  • Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.
  • Your maximum dose per day shouldn’t be higher than 400 mg.

Special dosage considerations

If you have risk factors for reduced clearance, such as liver disease: Your maximum dose per day shouldn’t be higher than 400 mg.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Immune disorder drugs

These drugs may increase the levels of Theodrip in your body. This means that you may have more side effects. An example of these drugs is:

What are the uses for Theodrip?

Theodrip is used for the relief and prevention of airway narrowing (bronchospasm) in patients with asthma. Theodrip also can be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway narrowing. Theodrip can be administered together with other bronchodilators, such as albuterol (Ventolin, Proventil) for added bronchodilator effect.


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