Terdan tablets


  • Active Ingredient: Theophylline
  • 400 mg
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What is Terdan?

The active ingredient of Terdan brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Terdan is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Terdan include: sleeplessness; unable to sleep; muscle pain or stiffness; persistent vomiting; shakiness in the legs, arms, hands, or feet; loss of appetite; shortness of breath; fever.

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Warnings for people with certain health problems

For people with liver disease: You may not be able to clear Terdan from your body well. This may increase the amount of this drug in your body and cause more side effects.

For people with heart failure: You may not be able to clear Terdan from your body well. This may increase the amount of this drug in your body and cause more side effects.

For people with ulcers: This drug may make your ulcers worse.

For people with seizures: This drug may make your seizures worse.

For people with an irregular heart rate: This drug may make your irregular heart rate worse.

For people with low thyroid levels: You may not be able to clear Terdan from your body well. This may increase the amount of this drug in your body and cause more side effects.


Terdan extended-release tablets are indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.

Gout drugs

These drugs may increase the levels of Terdan in your body. This means that you may have more side effects. An example of these drugs is:

Severe Side Effects of Terdan

You need immediate emergency medical treatment if you are experiencing:

What should I discuss with my veterinarian before giving Terdan ER?

Tell your veterinarian if your pet is allergic to Terdan, or if your pet has stomach ulcers; epilepsy; heart rhythm problems; congestive heart failure; fluid in the lungs; hypothyroid; fever; liver, or kidney disease. Tell your veterinarian if your pet is pregnant or lactating, or if you plan on breeding your pet.

Terdan for Dogs and Cats

The FDA has not approved Terdan for veterinary medicine, but it is commonly prescribed to treat heart failure, asthma, pulmonary edema, bronchitis, and chronic obstructive pulmonary disease in cats and dogs.

As with people, pets are more likely to experience issues with Terdan if they have certain health conditions or are also taking other medications.

Potential side effects include restlessness, upset stomach, frequent urination, and rapid heartbeat.

Always talk to your pet's veterinarian before giving your dog or cat any prescription drug, including Terdan.

Nursing Mothers:

Terdan is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. The concentration of Terdan in breast milk is about equivalent to the maternal serum concentration. An infant ingesting a liter of breast milk containing 10-20 mcg/mL of Terdan per day is likely to receive 10- 20 mg of Terdan per day. Serious adverse effects in the infant are unlikely unless the mother has toxic serum Terdan concentrations.

Why it's used

Terdan is used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic bronchitis.

Terdan may be used as part of a combination therapy. This means you may need to take it with other medications.

What is Terdan, and how does it work (mechanism of action)?

Terdan belongs to a class of medications called bronchodilators, used in treating asthma and other airway diseases. Asthma is a breathing problem caused by narrowing of the airways, the breathing passages that allow air to move in and out of the lungs. Airways can be narrowed due to accumulation of mucus, spasm of the muscles that surround these airways, or swelling of the lining of the airways. Airway narrowing leads to symptoms of shortness of breath, wheezing, cough, and congestion. The narrowed airways can open either spontaneously or with medications. Medications that open airways are called bronchodilators. Terdan opens airways by relaxing the smooth muscles in the walls of the airways. Terdan also can be helpful in patients with emphysema and chronic bronchitis when their symptoms are partially related to reversible airway narrowing. Terdan also strengthens right heart function and diaphragm movement. Terdan was approved by the FDA in April 1979.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

Long-term carcinogenicity studies have been carried out in mice (oral doses 30-150 mg/kg) and rats (oral doses 5-75 mg/kg). Results are pending.

Terdan has been studied in Ames salmonella, in vivo and in vitro cytogenetics, micronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic.

In a 14 week continuous breeding study, Terdan, administered to mating pairs of B6C3F 1 mice at oral doses of 120, 270 and 500 mg/kg (approximately 1.0-3.0 times the human dose on a mg/m² basis) impaired fertility, as ev >1 mice at oral doses of 40-300 mg/kg (approximately 2.0 times the human dose on a mg/m² basis). At the high dose, systemic toxicity was observed in both species including decreases in testicular weight.

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