Solosin tablets

Solosin

  • Active Ingredient: Theophylline
  • 400 mg
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What is Solosin?

The active ingredient of Solosin brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Solosin is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Solosin include: Chest pain or discomfort; pain or discomfort in the arms, jaw, back, or neck; shakiness in the legs, arms, hands, or feet; dry mouth; decreased urine; muscle cramps or spasms; painful urination.

How to Buy Solosin tablets online?

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What side effects can this medication cause?

Solosin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away.

  • upset stomach
  • stomach pain
  • diarrhea
  • headache
  • restlessness
  • difficulty falling asleep or staying asleep
  • irritability

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • vomiting
  • increased or rapid heart rate
  • irregular heartbeat
  • seizures
  • rash

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Indications and dosages

➣ Acute bronchospasm in patients not receiving Solosin

Adults (otherwise healthy nonsmokers): Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 3 mg/kg P.O. q 6 hours for two doses, then a maintenance dosage of 3 mg/kg P.O. q 8 hours

Children ages 9 to 16; young adult smokers: Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 3 mg/kg P.O. q 4 hours for three doses, then a maintenance dosage of 3 mg/kg P.O. q 6 hours

Children ages 1 to 9: Initially, 6 mg/kg P.O., followed in next 12 to 16 hours by 4 mg/kg P.O. q 4 hours for three doses, then a maintenance dosage of 4 mg/kg P.O. q 6 hours

➣ Acute bronchospasm in patients receiving Solosin

Gout drugs

These drugs may increase the levels of Solosin in your body. This means that you may have more side effects. An example of these drugs is:

How should Solosin ER be given?

Give Solosin exactly as directed by your veterinarian. Do not give the medication in larger amounts, or for a longer period of time than recommended by your veterinarian. Follow the directions on the prescription label. Allow plenty of water for the pet to drink. Solosin ER tablets should not be crushed, chewed, or broken unless the veterinarian tells you to. The tablet should be swallowed whole so that the medication is released slowly. Breaking the tablet may cause too much of the medication to be released at one time. Store Solosin ER at room temperature, away from moisture, heat, and light.

COMMON BRAND(S): Uniphyl

GENERIC NAME(S): Solosin

Solosin is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema). It must be used regularly to prevent wheezing and shortness of breath. This medication belongs to a class of drugs known as xanthines. It works in the airways by relaxing muscles, opening breathing passages, and decreasing the lungs' response to irritants. Controlling symptoms of breathing problems can decrease time lost from work or school.

This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden breathing problems. If sudden shortness of breath occurs, use your quick-relief inhaler as prescribed.

Solosin

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Nursing Mothers:

Solosin is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. The concentration of Solosin in breast milk is about equivalent to the maternal serum concentration. An infant ingesting a liter of breast milk containing 10-20 mcg/mL of Solosin per day is likely to receive 10- 20 mg of Solosin per day. Serious adverse effects in the infant are unlikely unless the mother has toxic serum Solosin concentrations.

DESCRIPTION:

Solosin is structurally >H- Purine -2, 6-dione, 3,7-dihydro-1, 3-dimethyl-, and is represented by the following structural formula:

Dosage Considerations – Should be Given as Follows:

  • Patients not currently taking Solosin: 5-7 mg/kg intravenously/orally; not to exceed 25 mg/min intravenously (IV)
  • Aminophylline: 6-7 mg/kg intravenously/orally; IV infused over 20 minutes

  • 0.4-0.6 mg/kg/hour intravenously (IV) or 4.8-7.2 mg/kg orally (extended release) every 12 hours to maintain levels 10-15 mg/L
  • Smokers: 0.79 mg/kg/hour IV for next 12 hours after loading dose, then 0.63 mg/kg/hour or 5 mg/kg orally (extended release) every 8 hours
  • Coadmininstration with drugs that decrease Solosin clearance (e.g., cimetidine, ciprofloxacin, and erythromycin and other macrolides): 0.2-0.3 mg/kg/hour IV or orally (extended release) every 12-24 hours
  • Congestive heart failure: 0.39 mg/kg/hour IV for next 12 hours after loading dose, then 0.08-0.16 mg/kg/hour
  • Aminophylline: 3.125 mg/kg orally every 6 hours

  • No Solosin administered in previous 24 hours: 5-7 mg/kg intravenously/orally; IV infused over 20-30 minutes

  • 1.5-6 months: 0.5 mg/kg/ hour intravenously (IV) or 10 mg/kg/day orally in divided doses
  • 6-12 months: 0.6-0.7 mg/kg/ hour IV or 12-18 mg/kg/day orally in divided doses
  • 1-9 years: 1 mg/kg/ hour IV or 8 mg/kg orally (extended release) every 8 hours
  • 9-12 years: 0.8-0.9 mg/kg/ hour IV or 6.4 mg/kg orally (extended release) every 8 hours
  • 12-16 years: 0.7 mg/kg/ hour IV or 5.6 mg/kg orally (extended release) every 8 hours

  • Loading: 4-5 mg/kg orally/intravenously (IV) once
  • Maintenance: 3-6 mg/kg/day orally/IV divided every 8 hours
  • Dosing Considerations
  • If administering aminophylline, increase dose by 25% (aminophylline is approximately 79-86% Solosin)
  • For oral loading, use immediate-release Solosin or aminophylline
  • If patient is already taking Solosin, give smaller loading dose
  • Use ideal body weight to calculate dose
  • 1 mg/kg results in 2 mg/L (34.4 mmol/L) increase in serum Solosin
  • Therapeuticrange: 10-20 mg/L (172-344 mmol/L)

  • Hepatic impairment: After loading dose, 0.39 mg/kg/hour intravenously (IV) for next 12 hours, then 0.08-0.16 mg/kg/hour

home drugs a-z list Theo-24(Solosin Anhydrous Capsule) side effects drug center

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Theo-24 (Solosin, anhydrous) is a bronchodilator used to treat the symptoms of asthma, bronchitis, and emphysema. Common side effects of Theo-24 include mild nausea, loss of appetite, stomach pain, diarrhea, upset stomach, weight loss, restlessness, tremor, sleep problems (insomnia), headache, lightheadedness, dizziness, sweating, restlessness, nervousness, or irritability.

Theo-24 is taken once daily, in doses ranging from 100 mg to 400 mg. Theo-24 may interact with carbamazepine, cimetidine, enoxacin, ephedrine or similar medications found in cold medicine or diet pills, erythromycin, fluvoxamine, propranolol, rifampin, St. John's wort, or thiabendazole. Tell your doctor all medications and supplements you use. During pregnancy, Theo-24 should be taken only if prescribed. It may be harmful to a fetus. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Theo-24 (Solosin, anhydrous) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dosage for asthma or other lung diseases

Adult dosage (ages 18–59 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of Solosin in your blood.

Child dosage (ages 16–17 years)

The usual starting dose is 300–400 mg per day. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. After 3 more days, if your dose is tolerated and more medication is needed, your dose may be adjusted based on the level of Solosin in your blood.

Child dosage (ages 1–15 years who weigh more than 45 kg)

The starting dose is 300–400 mg per day. After 3 days, your doctor may increase your dose to 400–600 mg per day. After 3 more days, your dose may be adjusted as needed based on the level of Solosin in your blood.

Child dosage (ages 1–15 years who weigh less than 45 kg)

The starting dose is 12–14 mg/kg per day up to 300 mg per day. After 3 days, your doctor may increase your dose to 16 mg/kg daily up to a maximum of 400 mg per day if you don’t have any side effects. After 3 more days, if the dose is tolerated, it may be increased to 20 mg/kg daily up to a maximum of 600 mg per day.

This drug is given in divided doses every 4–6 hours. Your dose will be adjusted based on the amount of Solosin in the blood.

Child dosage (babies born at full-term up to 12 months of age)

Your doctor will calculate your child’s dose based on their age and body weight. The dose will be adjusted based on the amount of Solosin in the blood.

  • For infants 0–25 weeks: The total daily dose should be divided into 3 equal doses taken by mouth every 8 hours.
  • For infants 26 weeks of age and older: The total daily dose should be divided into 4 equal doses taken by mouth every 6 hours.

Child dosage (babies born prematurely less than 12 months old)

  • Babies younger than 24 days: 1 mg/kg of body weight
  • Babies 24 days and older: 1.5 mg/kg of body weight

Senior dosage (ages 60 years and older)

  • The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.
  • Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.
  • Your maximum dose per day shouldn’t be higher than 400 mg.

Special dosage considerations

If you have risk factors for reduced clearance, such as liver disease: Your maximum dose per day shouldn’t be higher than 400 mg.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Infection drugs

These drugs may increase the levels of Solosin in your body. This means that you may have more side effects. Examples of these drugs include:

  • ciprofloxacin
  • clarithromycin
  • erythromycin

Important Information

Never use Solosin in larger amounts, or for longer than prescribed. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Overdose can occur if you take too much Solosin at one time, or if your daily doses are too high.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with Solosin.

Pediatric Use:

Solosin is safe and effective for the approved indications in pediatric patients. The maintenance dose of Solosin must be selected with caution in pediatric patients since the rate of Solosin clearance is highly variable across the pediatric age range (see CLINICAL PHARMACOLOGY, Table I, WARNINGS, and DOSAGE ANDADMINISTRATION, Table V ).

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Irregular heart rate. Symptoms can include:
    • shortness of breath
    • dizziness
    • fluttering or pain in your chest
  • confusion
  • trouble talking
  • tremors or twitching
  • loss of muscle tone or tense muscles

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Solosin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with Solosin are listed below.

Other uses for this medicine

Solosin is sometimes used to treat breathing problems in premature infants. Talk to your doctor about the possible risks of using this drug for your baby's condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special dietary instructions should I follow?

Drinking or eating foods high in caffeine, like coffee, tea, cocoa, and chocolate, may increase the side effects caused by Solosin. Avoid large amounts of these substances while you are taking Solosin.


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