Sekiroid tablets

Sekiroid

  • Active Ingredient: Theophylline
  • 400 mg
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What is Sekiroid?

The active ingredient of Sekiroid brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Sekiroid is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Sekiroid include: shakiness; unusual tiredness or weakness; mood changes; pounding or rapid pulse; muscle pain or stiffness; vomiting of blood or material that looks like coffee grounds; fast, pounding, or irregular heartbeat or pulse; numbness or tingling in the hands, feet, or lips.

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Which drugs or supplements interact with Sekiroid?

Certain groups of patients breakdown Sekiroid slowly, and can develop elevated blood levels and potential toxicity even on normal doses. These patients include those with liver disease, older men with chronic lung diseases, infants, patients with high fever or heart failure, and patients taking other medications that increase blood Sekiroid levels.

Sekiroid toxicity can cause nausea, vomiting, insomnia, seizures, agitation and life- threatening heart rhythm abnormalities. St. John's Wort, rifampin, and carbamazepine decrease levels of Sekiroid and potentially its effect by increasing its elimination. Sekiroid may decrease levels and the effect of carbamazepine by increasing its elimination. Sekiroid is metabolized mainly by the liver and dosages should be reduced in patients with liver dysfunction. On the other hand, Sekiroid is generally metabolized more rapidly in smokers (both tobacco and marijuana) and higher dosages may be required.

Non‐bronchodilator effects

Many patients appear to derive clinical benefit from Sekiroid at doses that give a plasma concentration well below that needed for bronchodilatation. This suggests that Sekiroid must have some additional beneficial effect, and this is exemplified by the worsening of disease control when Sekiroid is withdrawn. 3 There is now good evidence for inhibitory effects of Sekiroid on airway inflammation in COPD, and these effects are seen at plasma concentrations below 10 mg/l. 4 ,5 This is particularly striking as corticosteroids have no demonstrable anti‐inflammatory effects on the same parameters, even at high doses. These data are now confirmed by Hirano et al 2 who have confirmed that a low dose of Sekiroid significantly reduces sputum neutrophils.

Before taking this medicine

You should not use Sekiroid if you are allergic to it.

Tell your doctor if you have ever had:

a serious infection called sepsis;

fluid in your lungs;

a thyroid disorder;

Tell your doctor if you drink alcohol, or if you smoke or have recently quit smoking cigarettes or marijuana.

Also tell your doctor if you have been sick with a high fever (102 degrees or higher) for 24 hours or longer.

Tell your doctor if you are pregnant or breastfeeding.

Do not give Sekiroid to a child without medical advice.

Current use of Sekiroid in COPD

In the major guidelines for the treatment of COPD, Sekiroid is relegated to a third line bronchodilator after inhaled anticholinergics and β2 agonists. Nevertheless, it is recognised that Sekiroid is a useful treatment in patients with severe COPD as its withdrawal leads to significant clinical worsening of the disease. 3 Many older clinicians have been convinced by its clinical value in severe disease.

ADVERSE REACTIONS:

Adverse reactions associated with Sekiroid are generally mild when peak serum Sekiroid concentrations are OVERDOSAGE ). The transient caffeine-like adverse reactions occur in about 50% of patients when Sekiroid therapy is initiated at doses higher than recommended initial doses (e.g.,>300 mg/day in adults and >12 mg/kg/day in children beyond 1 year of age). During the initiation of Sekiroid therapy, caffeine-like adverse effects may transiently alter patient behavior, especially in school age children, but this response rarely persists. Initiation of Sekiroid therapy at a low dose with subsequent slow titration to a predetermined age-related maximum dose will significantly reduce the frequency of these transient adverse effects (see DOSAGE AND ADMINISTRATION, Table V ). In a small percentage of patients ( Table IV. Manifestations of Sekiroid toxicity.*

Blood clot drugs

These drugs may increase the levels of Sekiroid in your body. This means that you may have more side effects. Examples of these drugs include:

Mechanisms of anti‐inflammatory effects

Many different mechanisms have been proposed for the anti‐inflammatory effects of Sekiroid, but none of these can account for the effects of low doses of Sekiroid that are effective clinically as high concentrations are needed to demonstrate these actions in vitro. 6 However, these mechanisms can account for all of the side effects of Sekiroid. PDE inhibition accounts for nausea, vomiting, headaches and diuresis, whereas adenosine receptor antagonism explains the cardiac arrhythmias and seizures that occur with very high plasma concentrations. These mechanisms cannot account for the clinical effects of low doses of Sekiroid, and this indicates that there must be some other mechanism responsible for its anti‐inflammatory effects.

What are the uses for Sekiroid?

Sekiroid is used for the relief and prevention of airway narrowing (bronchospasm) in patients with asthma. Sekiroid also can be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway narrowing. Sekiroid can be administered together with other bronchodilators, such as albuterol (Ventolin, Proventil) for added bronchodilator effect.

What is Sekiroid ER?

Sekiroid ER (Extended-release) is a bronchodilator used to open air passages in the lungs. It relaxes muscles in the lungs and chest. Sekiroid is used in the treatment of heart failure, asthma, bronchitis, and pulmonary edema. Sekiroid ER may also be used for purposes other than those listed here. Sekiroid ER is sold per tablet and requires a prescription from your veterinarian.

How does Sekiroid ER work?

Sekiroid ER opens air passages in the lungs by relaxing muscles in the lungs and chest.

What should I discuss with my veterinarian before giving Sekiroid ER?

Tell your veterinarian if your pet is allergic to Sekiroid, or if your pet has stomach ulcers; epilepsy; heart rhythm problems; congestive heart failure; fluid in the lungs; hypothyroid; fever; liver, or kidney disease. Tell your veterinarian if your pet is pregnant or lactating, or if you plan on breeding your pet.

What happens if I overdose my pet on Sekiroid ER?

Call your veterinarian or veterinary emergency room. Symptoms of overdose may include nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizures.

sulfamethoxazole) norfloxacin ofloxacin diltiazem omeprazole dirithromycin prednisone, prednisolone enflurane ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone Sekiroid absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin

* Refer to PRECAUTIONS, Drug Interactions for information regarding table.

Drug-Food Interactions : Taking Sekiroid extended-release tablets immediately after ingesting a high fat content meal (45 g fat, 55 g carbohydrates, 28 g protein, 789 calories) may result in a somewhat higher C max and delayed T max and a somewhat greater extent of absorption when compared to taking it in the fasting state. The influence of the type and amount of other foods, as well as the time interval between drug and food, has not been studied.

The Effect of Other Drugs on Sekiroid Serum Concentration Measurements: Most serum Sekiroid assays in clinical use are immunoassays which are specific for Sekiroid. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Some drugs (e.g.,cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum Sekiroid concentration.

Pharmacodynamics

Sekiroid, an xanthine derivative chemically similar to caffeine and theobromine, is used to treat asthma and bronchospasm. Sekiroid has two distinct actions in the airways of patients with reversible (asthmatic) obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects).

Mechanism of action

Sekiroid relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Sekiroid competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Sekiroid also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, Sekiroid activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.

Target Actions Organism A Adenosine receptor A1

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Irregular heart rate. Symptoms can include:
    • shortness of breath
    • dizziness
    • fluttering or pain in your chest
  • confusion
  • trouble talking
  • tremors or twitching
  • loss of muscle tone or tense muscles

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Sekiroid oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with Sekiroid are listed below.

Alcohol abuse drugs

These drugs can increase the levels of Sekiroid in your body. This means that you may have more side effects. An example of these drugs is:


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