Neosayomol capsules

Neosayomol

  • Active Ingredient: Diphenhydramine
  • 25 mg
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What is Neosayomol?

The active ingredient of Neosayomol brand is diphenhydramine. Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Each 5 mL contains 12.5 mg of Diphenhydramine hydrochloride and alcohol 14% for oral administration. Inactive Ingredients: Citric acid, D&C Red No. 33, FD&C Red No. 40, flavoring, purified water, sodium citrate, and sucrose. A single oral dose of Diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of Diphenhydramine hydrochloride is from four to six hours. Diphenhydramine is widely distributed throughout the body, including the CNS. Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Used for

Neosayomol is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Cold Symptoms, Cough, Extrapyramidal Reaction, Insomnia, Motion Sickness, Nausea/Vomiting, Pruritus, Urticaria.

Side Effect

Possible side effects of Neosayomol include: ; ; ; ; ; .

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Urgent advice: Call your doctor straight away if you take too much Neosayomol by accident

If you need to go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.

Take the Neosayomol packet or leaflet inside it plus any remaining medicine with you.

Like all medicines, Neosayomol can cause side effects, although not everyone gets them. However, you may be more likely to get them if you're over 65.

Overview.

Neosayomol is generally dosed at 25 to 50 mg for the treatment of insomnia. H 1 antagonism is its greatest effect; muscarinic cholinergic antagonism is the next most important effect of Neosayomol. 102 This agent has a Tmax of 2 to 2.5 hours and a T1/2 of 5 to 11 hours. 3 The elimination of Neosayomol primarily involves the CYP2D6, CYP1A2, CYP2C9, and CYP2C19 liver P450 isoenzymes. 3

Benadryl Dosage

Each Benadryl tablet and liquid-filled capsule contains 25 milligrams (mg) of Neosayomol.

Children’s Benadryl liquid has 12.5 mg per teaspoon.

If you are using a Benadryl capsule, you should not open the capsule; instead, swallow it whole.

If you are using Benadryl liquid, do not use a kitchen teaspoon to measure a dose. Use the measuring cup that comes with the medication.

Typical doses for Benadryl are:

  • For adults and children older than 12, take 1 to 2 tablets or capsules every 4 to 6 hours as needed.
  • For children ages 6 to 11, take 1 tablet or capsule every 4 to 6 hours as needed, or 1 to 2 teaspoons of Benadryl liquid every 4 to 6 hours as needed.
  • For children younger than 6, consult the child’s doctor.

Giving Neosayomol to children

For some symptoms, you can give Neosayomol to children over the age of 6 years. Check with your pharmacist or doctor to make sure whether a product is suitable for your child.

Serious Reactions

With the use of any drug, there are also risks of serious side effects. These occur more rarely. When using Neosayomol, these may include:

  • Anaphylaxis (severe allergic reaction including difficulty breathing)
  • Low blood cell counts (agranulocytosis, anemia, thrombocytopenia, and leukopenia)
  • Abnormal heart rhythms
  • Seizures
  • Toxic psychosis  
  • Acute labyrinthitis (inner ear problems)

What Are Warnings and Precautions for Neosayomol?

  • Elderly patients: Considered high-risk medication for this age group because it may increase risk of falls and has high incidence of anticholinergic effects; it may exacerbate existing lower urinary tract conditions or benign prostatic hyperplasia; use in special situations may be appropriate; Neosayomol is not recommended for treatment of insomnia, because tolerance develops and risk of anticholinergic effects increases
  • This medication contains Neosayomol. Do not take Benadryl, Benadryl Allergy Dye-Free LiquiGels, Children's Benadryl Allergy, Children's Triaminic Thin Strips Allergy, Alka-Seltzer Plus Allergy, Nytol, PediaCare Children's Allergy, Simply Sleep, Sominex, QlearQuil Nighttime Allergy Relief, Tranquil Nighttime Sleep Aid, Unisom SleepGels, Unisom SleepMelts, or ZzzQuil if you are allergic to Neosayomol or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

  • Documented hypersensitivity
  • Lower respiratory tract disease, such as acute asthma (controversial)
  • Premature infants or neonates
  • Nursing mothers
  • Use as local anesthetic
  • To make children under 6 years old sleep, when used for self-medication

Effects of Drug Abuse

  • Patients may develop a tolerance for Neosayomol

  • May cause central nervous systemdepression, which can impair driving or operating heavy machinery. May increase the effects of sedatives such as alcohol
  • See "What Are Side Effects Associated with Using Neosayomol?"

  • Neosayomol is not recommended for treatment of insomnia in elderly patients, because tolerance develops and risk of anticholinergic effects increases.
  • See "What Are Side Effects Associated with Using Neosayomol?"

  • May cause central nervous system depression, which can impair driving or operating heavy machinery
  • May potentiate effects of sedatives such as alcohol
  • Use caution in patients with angle-closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and thyroiddysfunction
  • Elderly patients: Considered high-risk medication for this age group because it may increase risk of falls and has high incidence of anticholinergic effects; may exacerbate existing lower urinary tract conditions or benign prostatic hyperplasia; use in special situations may be appropriate; not recommended for treatment of insomnia, because tolerance develops and risk of anticholinergic effects increases

  • Neosayomol use in pregnancy may be acceptable
  • Either animal studies show no risk but human studies are not available, or animal studies showed minor risks and human studies were done and showed no risk
  • Neosayomol enters into breast milk, therefore do not use Neosayomol when lactating

What is Neosayomol, and how does it work (mechanism of action)?

Neosayomol is an antihistamine used for treating allergic reactions. Histamine is released by the body during several types of allergic reactions and--to a lesser extent--during some viral infections, such as the common cold. When histamine binds to receptors on cells, it stimulates changes within the cells that lead to the release of chemicals that cause sneezing, itching, and increased mucus production. Antihistamines compete with histamine for cell receptors and bind to the receptors without stimulating the cells. In addition, they prevent histamine from binding and stimulating the cells. Neosayomol also blocks the action of acetylcholine (anticholinergic effect) and is used as a sedative because it causes drowsiness. The FDA originally approved Neosayomol in 1946.


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