Microphyllin tablets


  • Active Ingredient: Theophylline
  • 400 mg
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What is Microphyllin?

The active ingredient of Microphyllin brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Microphyllin is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Microphyllin include: fast, pounding, or irregular heartbeat or pulse; increase in urine volume; loss of appetite; confusion; dizziness; sleeplessness; irregular heartbeat.

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How should I take Microphyllin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Never use Microphyllin in larger amounts, or for longer than prescribed.

Microphyllin is not a rescue medicine for asthma or bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Swallow the capsule or tablet whole and do not crush or chew it. You may break a scored tablet in half if needed to get the correct dose.

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Your dose and the number of times you take Microphyllin daily will depend on the reason you are taking this medication.

Follow your doctor's instructions about whether to take your medication with food or on an empty stomach.

Your dose needs may change if you are ill, or if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need regular medical tests to be sure you are using the right dose. Do not change your dose or dosing schedule without your doctor's advice.

Microphyllin doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Microphyllin.

Store at room temperature away from moisture, heat, and light.

Is Microphyllin safe to take if I'm pregnant or breastfeeding?

There are no adequate studies in pregnant women.

Microphyllin is excreted in breast milk and may cause mild side effects such as irritability in the infant.

Dosage Considerations – Should be Given as Follows:

  • Patients not currently taking Microphyllin: 5-7 mg/kg intravenously/orally; not to exceed 25 mg/min intravenously (IV)
  • Aminophylline: 6-7 mg/kg intravenously/orally; IV infused over 20 minutes

  • 0.4-0.6 mg/kg/hour intravenously (IV) or 4.8-7.2 mg/kg orally (extended release) every 12 hours to maintain levels 10-15 mg/L
  • Smokers: 0.79 mg/kg/hour IV for next 12 hours after loading dose, then 0.63 mg/kg/hour or 5 mg/kg orally (extended release) every 8 hours
  • Coadmininstration with drugs that decrease Microphyllin clearance (e.g., cimetidine, ciprofloxacin, and erythromycin and other macrolides): 0.2-0.3 mg/kg/hour IV or orally (extended release) every 12-24 hours
  • Congestive heart failure: 0.39 mg/kg/hour IV for next 12 hours after loading dose, then 0.08-0.16 mg/kg/hour
  • Aminophylline: 3.125 mg/kg orally every 6 hours

  • No Microphyllin administered in previous 24 hours: 5-7 mg/kg intravenously/orally; IV infused over 20-30 minutes

  • 1.5-6 months: 0.5 mg/kg/ hour intravenously (IV) or 10 mg/kg/day orally in divided doses
  • 6-12 months: 0.6-0.7 mg/kg/ hour IV or 12-18 mg/kg/day orally in divided doses
  • 1-9 years: 1 mg/kg/ hour IV or 8 mg/kg orally (extended release) every 8 hours
  • 9-12 years: 0.8-0.9 mg/kg/ hour IV or 6.4 mg/kg orally (extended release) every 8 hours
  • 12-16 years: 0.7 mg/kg/ hour IV or 5.6 mg/kg orally (extended release) every 8 hours

  • Loading: 4-5 mg/kg orally/intravenously (IV) once
  • Maintenance: 3-6 mg/kg/day orally/IV divided every 8 hours
  • Dosing Considerations
  • If administering aminophylline, increase dose by 25% (aminophylline is approximately 79-86% Microphyllin)
  • For oral loading, use immediate-release Microphyllin or aminophylline
  • If patient is already taking Microphyllin, give smaller loading dose
  • Use ideal body weight to calculate dose
  • 1 mg/kg results in 2 mg/L (34.4 mmol/L) increase in serum Microphyllin
  • Therapeuticrange: 10-20 mg/L (172-344 mmol/L)

  • Hepatic impairment: After loading dose, 0.39 mg/kg/hour intravenously (IV) for next 12 hours, then 0.08-0.16 mg/kg/hour

Microphyllin is a bronchodilator used for the relief of asthma that has a number of other pharmacological effects, notably the stimulation of cardiac output and the dilatation of peripheral blood vessels.

How to use Microphyllin ANHYDROUS

Take this medication by mouth as directed by your doctor, usually once or twice daily. Since different manufacturers have different ways to take this medication, ask your doctor or pharmacist about the best time(s) to take your brand of Microphyllin and if you should take the drug with or without food.

Do not crush or chew the capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

The dosage is based on your medical condition, response to treatment, age, weight, lab tests (Microphyllin blood levels), and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Certain diets (such as high protein/low carbohydrate or high carbohydrate/low protein) may change the effect of Microphyllin. Tell your doctor if you have any major changes in your diet. Your doctor may need to adjust your dose.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Do not increase your dose, take this drug more often, or stop taking it without first consulting your doctor.

Get medical help right away if your asthma symptoms worsen or if you are using your quick-relief inhaler more than usual or more often than prescribed.

* These data are derived from two studies in patients with serum Microphyllin concentrations >30 mcg/mL. In the first study (Study #1 - Shanon, Ann Intern Med 1993; 119:1161-67), data were prospectively collected from 249 consecutive cases of Microphyllin toxicity referred to a regional poison center for consultation. In the second study (Study #2 - Sessler, Am J Med 1990;88:567-76), data were retrospectively collected from 116 cases with serum Microphyllin concentrations >30 mcg/mL among 6000 blood samples obtained for measurement of serum Microphyllin concentrations in three emergency departments. Differences in the incidence of manifestations of Microphyllin toxicity between the two studies may reflect sample selection as a result of study design (e.g., in Study #1, 48% of the patients had acute intoxications versus only 10% in Study #2) and different methods of reporting results.

** NR = Not reported in a comparable manner.


Pharmacologic class: Xanthine derivative

Therapeutic class: Bronchodilator, spasmolytic

Pregnancy risk category C

Drug Interactions:

Drug-Drug Interactions: Microphyllin interacts with a wide variety of drugs. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to Microphyllin or another drug or occurrence of adverse effects without a change in serum Microphyllin concentration. More frequently, however, the interaction is pharmacokinetic, i.e., the rate of Microphyllin clearance is altered by another drug resulting in increased or decreased serum Microphyllin concentrations. Microphyllin only rarely alters the pharmacokinetics of other drugs.

The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with Microphyllin. The information in the “Effect” column of Table II assumes that the interacting drug is being added to a steady-state Microphyllin regimen. If Microphyllin is being initiated in a patient who is already taking a drug that inhibits Microphyllin clearance (e.g., cimetidine, erythromycin), the dose of Microphyllin required to achieve a therapeutic serum Microphyllin concentration will be smaller. Conversely, if Microphyllin is being initiated in a patient who is already taking a drug that enhances Microphyllin clearance (e.g., rifampin), the dose of Microphyllin required to achieve a therapeutic serum Microphyllin concentration will be larger. Discontinuation of a concomitant drug that increases Microphyllin clearance will result in accumulation of Microphyllin to potentially toxic levels, unless the Microphyllin dose is appropriately reduced. Discontinuation of a concomitant drug that inhibits Microphyllin clearance will result in decreased serum Microphyllin concentrations, unless the Microphyllin dose is appropriately increased.

The drugs listed in Table III have either been documented not to interact with Microphyllin or do not produce a clinically significant interaction (i.e., The healthcare professional should not assume that a drug does not interact with Microphyllin if it is not listed in Table II . Before addition of a newly available drug in a patient receiving Microphyllin, the package insert of the new drug and/or the medical literature should be consulted to determine if an interaction between the new drug and Microphyllin has been reported.

Table II. Clinically significant drug interactions with Microphyllin.*

How it works

Microphyllin belongs to a class of drugs called methylxanthines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Microphyllin works by opening the airways in your lungs. It does this by relaxing the muscles and decreasing the response to substances that cause your airways to constrict. This makes it easier for you to breathe.

Microphyllin oral tablet doesn’t cause drowsiness but it can cause other side effects.

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