Histaxin capsules


  • Active Ingredient: Diphenhydramine
  • 25 mg
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What is Histaxin?

The active ingredient of Histaxin brand is diphenhydramine. Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Each 5 mL contains 12.5 mg of Diphenhydramine hydrochloride and alcohol 14% for oral administration. Inactive Ingredients: Citric acid, D&C Red No. 33, FD&C Red No. 40, flavoring, purified water, sodium citrate, and sucrose. A single oral dose of Diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of Diphenhydramine hydrochloride is from four to six hours. Diphenhydramine is widely distributed throughout the body, including the CNS. Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Used for

Histaxin is used to treat diseases such as: Allergic Reactions, Allergic Rhinitis, Cold Symptoms, Cough, Extrapyramidal Reaction, Insomnia, Motion Sickness, Nausea/Vomiting, Pruritus, Urticaria.

Side Effect

Possible side effects of Histaxin include: ; ; ; ; .

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How should this medicine be used?

Histaxin comes as a tablet, a rapidly disintegrating (dissolving) tablet, a capsule, a liquid-filled capsule, a dissolving strip, powder, and a liquid to take by mouth. When Histaxin is used for the relief of allergies, cold, and cough symptoms, it is usually taken every 4 to 6 hours. When Histaxin is used to treat motion sickness, it is usually taken 30 minutes before departure and, if needed, before meals and at bedtime. When Histaxin is used to treat insomnia it is taken at bedtime (30 minutes before planned sleep). When Histaxin is used to treat abnormal movements, it is usually taken three times a day at first and then taken 4 times a day. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Histaxin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or directed on the label.

Histaxin comes alone and in combination with pain relievers, fever reducers, and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain Histaxin, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4 to 11 years of age, use caution and follow the package directions carefully.

If you are giving Histaxin or a combination product that contains Histaxin to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give Histaxin products that are made for adults to children.

Before you give a Histaxin product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

If you are taking the dissolving strips, place the strips on your tongue one at a time and swallow after they melt.

If you are taking the rapidly dissolving tablets, place a tablet on your tongue and close your mouth. The tablet will quickly dissolve and can be swallowed with or without water.

If you are taking the capsules, swallow them whole. Do not try to break the capsules.

Mixing Histaxin with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside Histaxin - especially ones that cause side effects such as sleepiness, a dry mouth or make it difficult to pee.

Q: I have been taking Benadryl for almost a year to help with allergies and sleep. Sleep problems have always been an issue for me, and I decided to stop Seroquel and Ambien. I also have tried melatonin. I work nights without the option to switch to days. What are the side effects of long-term use of Benadryl?

A: Your question regards what side effects are associated with the use of Benadryl (Histaxin) //www.everydayhealth.com/drugs/benadryl According to ePocrates, the most common reactions associated with the use of Benadryl include the following: drowsiness, dizziness, incoordination, headache, epigastric (upper central area of the abdomen) discomfort, thickening of the pulmonary secretions, dry mucous membranes, paradoxical CNS stimulation, constipation, dysuria (painful urination), urinary retention, hypotension (low blood pressure), blurred vision, diplopia (double vision), palpitations, tachycardia (fast heart beat), photosensitivity, diaphoresis (excessive sweating), and erectile dysfunction. If you are experiencing or begin to experience any of these side effects, contact your physician. As always, talk with your physician regarding questions you have about your medications and if Benadryl is a good option for long term treatment of your sleep issues. Attached is a link to additional information provided by Everyday Health regarding insomnia. //www.everydayhealth.com/insomnia/guide/. Jen Marsico, RPh

Benadryl S >

You should tell your doctor about any side effects from Benadryl and other Histaxin products.

Common side effects may include:

  • Drowsiness
  • Dry mouth
  • Dry nose and throat
  • Dizziness
  • Nausea
  • Headache
  • Feeling jittery (especially in children)
  • Tightness in the chest
  • Weakness
  • Constipation
  • Loss of appetite

Benadryl and other Histaxin products can have some serious side effects. If you have any of these side effects, stop taking Benadryl and call your doctor right away:

  • Change in vision
  • Trouble passing urine
  • Trouble breathing

Q: My wife goes thru at least one bottle a week of children's dye-free Benadryl. She does have allergies, but there seems to be an unhealthy emotional dependence on it also. She panics if she is out of it or if she is running low. She keeps a bottle in her car, one at home, and one at work, just in case. Are there any harmful physical side effects? She has been taking this for years.

A: Benadryl (Histaxin) is used for allergies and sometimes available in sleep products like Tylenol PM. Side effects of Benadryl can be drowsiness, dry mouth, and dizziness. Continued use of Benadryl over time can probably cause a tolerance to it. Therefore, it takes more of the drug to do the desired effect. There recommend max daily dose of Benadryl for an adult is 150 mg/day. Any dosage exceeding this or use for a long period of time should be consulted with a physician. There are newer antihistamines now available over-the-counter such as Claritin or Zyrtec that might be beneficial for the allergies. For more information on these drugs, visit www.everydayhealth.com/drugs/. Kimberly Hotz, PharmD

What if I forget my medicine?

If you're taking Histaxin to help you sleep and you forget to take it by bedtime, skip your missed dose and start again the next evening.

If you're taking any other medicine containing Histaxin and forget to take a dose, take your medicine when you next need it to ease your symptoms.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

Benadryl Interactions

Always tell your doctor or pharmacist about any drugs you take, including prescription drugs, other OTC drugs, and any vitamins, dietary supplements, illegal or recreational drugs, or herbal remedies.

Certain drugs interact with Benadryl and may cause problems. These include:

  • Other medications that contain Histaxin, including creams and gels
  • Alcohol
  • Diazepam (Valium), a benzodiazepine used to treat anxiety, seizures, and other conditions
  • Sedatives, sleeping pills, muscle relaxants, tranquilizers, and other drugs that are central nervous system depressants
  • Allergy medications
  • Anxiety medications, such as alprazolam (Xanax), lorazepam (Ativan), and temazepam (Restoril)
  • Monoamine oxidase inhibitors (MAOIs) used to treat depression.
  • Prescription pain medications Liqu > Many different solvents were used for extraction of Histaxin from biological matrices at slightly alkaline pH. They include butyl acetate, diethyl ether, toluene, ethyl acetate, dichloromethane or others. Often mixtures of these solvents were used . As all these procedures work quite well with sufficient recoveries, no special recommendation is given here.

Histaxin has no derivatizable groups. Therefore, derivatization is not used, if only the parent compound is targeted . However, the demethyl metabolites as well as the hydroxy metabolites and the products of acid hydrolysis (cf. 6.5.2) should be derivatized for better chromatographic properties. Trimethylsilylation, acetylation or perfluoroacylation should be suitable. Derivatization using N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide is also described . Mass spectra of Histaxin and of its derivatized metabolites and hydrolysis products can be found in refs. . For more information on derivatization procedures, the review of Segura et al. and for even more detailed information the review series by Halket and Zaikin, Halket et al. and Zaikin and Halket are recommended .

How to use Histaxin Hcl

Follow all directions on the product package. If your doctor has prescribed this medication, take it as directed. If you are uncertain about any of the information, consult your doctor or pharmacist.

Take the tablet, capsule, or liquid form by mouth with or without food. Measure liquid forms of this medication using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you have a single-dose form of this medication (such as a single-use whistle), you do not need to measure the dose.

The rapidly-dissolving tablet or strip should be allowed to dissolve on the tongue and then swallowed, with or without water. The chewable tablets should be chewed thoroughly before being swallowed.

The dosage is based on your age, medical condition, and response to treatment. There are many brands and forms of Histaxin available. Read the dosing instructions carefully for each product because the amount of Histaxin may be different between products. Do not increase your dose or take this medication more often than directed.

To prevent motion sickness, take your dose 30 minutes before starting activity such as travel. To help you sleep, take your dose about 30 minutes before bedtime. If you continue to have difficulty sleeping for longer than 2 weeks, contact your doctor.

Tell your doctor if your condition does not improve or if it worsens.

¿Cuál es la información más importante que debo saber sobre Histaxin?

Usted no debe usar un medicamento antihistamínico para causarle sueño a un niño.

Q: I take two Benadryl every night to help me sleep. Is this safe? I have been doing this for years.

A: Benadryl (Histaxin), //www.everydayhealth.com/drugs/benadryl, is a safe sleeping aid as long as the patient can tolerate the side effects. It does not cause dependency, but it has many side effects. It may cause drowsiness upon awakening. It may cause dry mouth, dry eyes and urinary retention. Benadryl should be avoided in people who have prostate enlargement, glaucoma or asthma. Other sleep aids worth looking at are melatonin to help falling asleep and valerian. Lori Mendoza, Pharm

Is Histaxin safe to take if I'm pregnant or breastfeeding?

Histaxin has not been adequately evaluated in pregnant women. It should be used only if the benefit outweighs the potential but unknown risks.

NURSING MOTHERS: Histaxin is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.

Ev >Sleep-enhancing effects of diphenhy­dramine have been observed in placebo-controlled trials of sleep disturbance in a mixed group of psychiatric patients, outpatients in a primary care practice, nursing home residents, and primary insomnia patients. 102-107 Of note, the effects appear to be more consistent on sleep maintenance than on sleep onset. Whereas this may, at least in part, reflect the Tmax of 2 hours, a greater effect on the maintenance of sleep than on sleep initiation was also noted with doxepin in low dose, at which it is a highly selective H1 antagonist. In a study examining the sedating effects associated with daytime dosing of Histaxin , a sedating effect on the first day of treatment was no longer present on the fourth day of treatment. 108

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