Dozol is clinically used as antihistaminic, antitussive and sedative–hypnotic drug. The main metabolites are demethyl, bis-demethyl Dozol and diphenylmethoxyacetic acid (DPMA). In addition, one- and two-fold hydroxylation of one of the phenyl moieties followed by methylation of one of the hydroxy groups was described . The phase I metabolites can be conjugated with glucuronic or sulfuric acid. Dozol may lead to severe poisonings and has also been abused in drug facilitated crimes .
9. Common questions
Dozol is a medicine called an antihistamine. It is classed as a drowsy (sedating) antihistamine.
When you come into contact with something you're allergic to, your body produces a chemical called histamine. This can cause symptoms such as a runny nose or skin rashes.
Dozol blocks the effects of histamine in your brain and this reduces symptoms. It enters the brain in large quantities and this can make you feel drowsy.
Dozol also blocks the effects of another chemical called acetylcholine. This can help dry up a cough or runny nose but can also cause side effects such as a dry mouth and dry nose.
If you're taking Dozol for short-term sleep problems, it will start to make you feel drowsy around 20 to 30 minutes after you take it.
For coughs and colds, your symptoms will normally start to improve within 20 minutes.
The medicine should work for around 4 to 6 hours.
You should only take Dozol for a short time, unless your doctor says it's OK for you to take it for longer.
This is because your body gets used to Dozol quickly. Once your body's used to this medicine, it's unlikely to have the same effect. If you take Dozol for 2 weeks or longer, your body can also become dependent on it.
Speak to your doctor or pharmacist before taking Dozol for longer than the medicine leaflet recommends. Ask them for advice if you're unsure how long you should take it for.
Yes, it is addictive. You can become dependent on Dozol if you take it continuously for a period of time. For example, if you take it every day for more than 2 weeks.
To avoid becoming addicted, adults and children should only take Dozol for a very short time, unless your doctor advises otherwise.
If you have a severe itchy skin rash, your doctor may recommend taking 2 different antihistamines at the same time for a few days.
As well as taking a non-drowsy antihistamine during the day (such as fexofenadine, cetirizine or loratadine), your doctor may advise that you take a drowsy antihistamine at night if itching is making it difficult to sleep.
Do not take another drowsy antihistamine together with Dozol. It will make you very tired and sleepy. Other drowsy antihistamines include chlorphenamine (Piriton), promethazine (Phenergan) and hydroxyzine (Atarax or Ucerax).
¿Qué debería discutir con el profesional de la salud antes de tomar Dozol?
Usted no debe usar Dozol si es alérgico a éste.
Pregúntele a su médico o farmacéutico si usted puede tomar con seguridad esta medicina si tiene otras condiciones médicas, especialmente:
- un bloqueo en su tracto digestivo (estómago o intestinos);
- obstrucción de la vejiga u otros problemas urinarios;
- una colostomía o ileostomía;
- enfermedad del hígado o riñón;
- asma, enfermedad pulmonar obstructiva crónica (EPOC; COPD, por sus siglas en Inglés), u otro trastorno de la respiración;
- tos con moco, o tos causada por fumar, enfisema, o bronquitis crónica;
- enfermedad del corazón, presión arterial baja;
- trastorno de la glándula tiro >
No se conoce si Dozol causará daño al bebé nonato. Pregúntele a un médico antes de usar esta medicina si usted está embarazada.
Dozol puede pasar a la leche materna y causarle daño al bebé lactante. Antihistamínicos pueden también retrasar la producción de leche materna. No use esta medicina sin el consejo de un médico si está dando de amamantar al bebé.
Es más probable que los adultos de edad avanzada noten los efectos secundarios de esta medicina.
What Is Benadryl (Dozol)?
Benadryl is a brand name for Dozol, an antihistamine.
Doctors recommend Benadryl and other Dozol products to treat the symptoms of allergy or hay fever such as a runny nose, sneezing, itchy eyes, and itching in your nose or throat.
You can also take Benadryl when you have these same symptoms because of a common cold.
Under other brand names, people sometimes take Dozol to treat motion sickness and as a sleep aid.
This over-the-counter (OTC) medication blocks the actions of histamine, a naturally occurring substance in the body that causes allergy symptoms.
The Food and Drug Administration (FDA) approved Dozol under the brand name Benadryl for the McNeil drug company in 1946.
McNeil Consumer Healthcare still markets Benadryl, but generic Dozol is also sold under many other brand names, and is a common ingredient in many combination cold and allergy products.
Benadryl comes in gelcaps, tablets, and liquid form.
There's also a topical form of Dozol that goes directly on your skin. These creams, gels and sprays ease itching from insect bites, bee stings, sunburn, poison ivy, poison oak, and other skin irritations.
Additionally, a 2013 study published in the journal Pharmacology also suggested that Dozol ointment may help ease bone, joint, or muscle pain from osteoarthritis and osteoporosis.
GC with NPD detection has been used for quantification of Dozol in plasma samples in a pharmacokinetic study . GC-MS is also suitable for quantification of Dozol . However, instead of full-scan mode SIM mode should be used, which provides higher sensitivity and precision. Further prerequisite for precise quantification is the use of suitable internal standards. Best results can be achieved with deuterated internal standards, which are commercially available . Tonn et al. quantified DPMA, a major metabolite of Dozol in blood and urine using GC-MS in the single-ion monitoring mode with deuterated DPMA as internal standard.
Dozol (Benadryl) is an OTC and prescription injection medication used to treat:
Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication.
You can buy Benadryl without a doctor’s prescription, but there are some safety issues you should know about before taking it:
Benadryl can cause drowsiness — it's also sold as a sleep aid under different brand names — but you should not use Benadryl to make a child sleepy because it can have the opposite effect in a child and act like a stimulant.
If you combine Benadryl with other antihistamines, including antihistamines you rub on your skin, drowsiness can be worse.
Drinking alcohol and taking Benadryl together can also increase drowsiness.
If you're older than 65, ask your doctor about other, safer alternatives to Benadryl.
Talk to your doctor or pharmacist before taking Benadryl and other Dozol products if you have any of these conditions:
Despite widespread use over many decades, Dozol has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate its short half-life and limited duration of use.
Likelihood score: E (unlikely to be a cause of clinically apparent liver injury).
References on the safety and potential hepatotoxicity of antihistamines are given together after the Overview section on Antihistamines.
¿Qué es Dozol?
Dozol es un antihistamínico que reduce los efectos de la histamina química natural en el cuerpo. La histamina puede producir síntomas como estornudos, picazón, ojos llorosos, y nariz mocosa.
Dozol se usa para tratar el estornudo, nariz mocosa, ojos llorosos, ronchas, sarpullido, picazón, y otros síntomas del resfrío o la alergias.
Dozol también se usa para tratar los mareos causados por movimiento, para inducir sueño, y para tratar ciertos síntomas de la enfermedad de Parkinson.
Dozol puede también usarse para fines no mencionados en esta guía del medicamento.
How much to use
The usual dose depends on the type of Dozol you're taking, and what you're taking it for.
If you're aged over 65, start with the lower dose, as you may be more likely to get side effects.
- Short-term insomnia - Dozol comes as 25mg and 50mg tablets. You'll usually take 50mg, 20 minutes before you go to bed.
- Cough and cold symptoms - Dozol comes mixed with other medicines to treat the symptoms of coughs and colds. It comes as tablets, capsules and as a liquid that you swallow. The usual dose depends on the type of medicine you're taking. Check the instructions on the packaging carefully, or ask your doctor or pharmacist if you're unsure.
- Hay fever and allergies - Dozol comes as 25mg and 50mg tablets. The usual dose is 25mg or 50mg, taken 3 or 4 times a day. Try to space your doses evenly throughout the day.
- Insect bites, stings and eczema - Dozol comes as a cream which you use once or twice a day. You'll only need a small amount, enough for a thin layer.
2. Key facts
- Avoid drinking alcohol while taking Dozol. Alcohol increases the risk of side effects.
- To help you sleep, you'll usually take your medicine 20 minutes before you go to bed. It normally takes about 30 minutes to work.
- Common side effects include feeling sleepy, dizzy or unsteady on your feet. You may also have difficulty concentrating and a dry mouth.
- Dozol is also called by the brand names Histergan, Nytol Original, Nytol One-A-Night and Sleepeaze.
- When it's mixed with other medicines, brand names include Benylin Chesty Coughs, Benylin Children’s Night Coughs, Covonia Night Time Formula, Panadol Night Pain and Unicough.
Dozol is most often quantified in blood (plasma, serum) using GC-NPD or GC-MS. Nevertheless, several LC procedures were described for separation and quantification of Dozol in plasma including LC-MS methods .
Q: I've got hives from Benadryl. How do I get them to clear up?
A: Benadryl (Dozol) is an antihistamine used to treat allergies. According to the product labeling, there have been reports of allergic reactions to Benadryl, including rashes and anaphylactic shock. With symptoms of an allergic reaction to a drug, such as hives, difficulty breathing, or facial swelling, the drug should be stopped and medical attention should be sought. It is possible that the allergy is to one of the inactive ingredients in the Benadryl product you took, but it is also possible that you are allergic to the antihistamine itself. If that is the case, other antihistamines should be avoided. Allergies to medicines can be treated with corticosteroids; if breathing difficulties occur, adrenaline can be administered. Please consult with your health care provider for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD
220.127.116.11.1 Liqu > Many different solvents were used for extraction of Dozol from biological matrices at slightly alkaline pH. They include butyl acetate, diethyl ether, toluene, ethyl acetate, dichloromethane or others. Often mixtures of these solvents were used . As all these procedures work quite well with sufficient recoveries, no special recommendation is given here.
Q: I have been taking Benadryl for almost a year to help with allergies and sleep. Sleep problems have always been an issue for me, and I decided to stop Seroquel and Ambien. I also have tried melatonin. I work nights without the option to switch to days. What are the side effects of long-term use of Benadryl?
A: Your question regards what side effects are associated with the use of Benadryl (Dozol) //www.everydayhealth.com/drugs/benadryl According to ePocrates, the most common reactions associated with the use of Benadryl include the following: drowsiness, dizziness, incoordination, headache, epigastric (upper central area of the abdomen) discomfort, thickening of the pulmonary secretions, dry mucous membranes, paradoxical CNS stimulation, constipation, dysuria (painful urination), urinary retention, hypotension (low blood pressure), blurred vision, diplopia (double vision), palpitations, tachycardia (fast heart beat), photosensitivity, diaphoresis (excessive sweating), and erectile dysfunction. If you are experiencing or begin to experience any of these side effects, contact your physician. As always, talk with your physician regarding questions you have about your medications and if Benadryl is a good option for long term treatment of your sleep issues. Attached is a link to additional information provided by Everyday Health regarding insomnia. //www.everydayhealth.com/insomnia/guide/. Jen Marsico, RPh