Bexitrol

Bexitrol

  • Active Ingredient: Salmeterol
  • 25mcg
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What is Bexitrol?

The active ingredient of Bexitrol brand is salmeterol. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.

Used for

Bexitrol is used to treat diseases such as: Asthma, Maintenance, Bronchospasm Prophylaxis, COPD, Maintenance.

Side Effect

Possible side effects of Bexitrol include: fainting; dry mouth; swelling; cough or hoarseness; bone pain.

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What is Bexitrol, and how does it work (mechanism of action)?

Asthma is a breathing problem involving narrowing of the airways. Airways are breathing passages that allow air to move in and out of the lungs. In patients with asthma, airways can be narrowed by accumulation of mucus, spasm of the muscles that surround these airways, or swelling of the lining of the airways. Airway narrowing lead to symptoms of shortness of breath, wheezing, cough, and congestion. Medications used in treating asthma open airways are called bronchodilators. Bexitrol is a bronchodilator of the beta-2 agonist type. Beta-2 agonists are medications that stimulate beta-2 receptors on the smooth muscle cells that line the airways, causing these muscle cells to relax, thus, opening airways.

Certain allergens (such as pollen) can cause airway narrowing by inducing release of histamine by mast cells. Histamine is a natural chemical that causes tissue swelling and other allergic reactions in the body when released into the tissue. Mast cells belong to a class of immune cells located around the airways. Bexitrol is an inhaled medication that blocks the release of histamine by the mast cells, thus preventing airway narrowing when exposed to allergens.

(R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Bexitrol. (S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Bexitrol. 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid The risk or severity of hypertension can be increased when Bexitrol is combined with 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid. 1-benzylimidazole The risk or severity of hypertension can be increased when Bexitrol is combined with 1-benzylimidazole. 2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Bexitrol is combined with 2,5-Dimethoxy-4-ethylamphetamine. 2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of hypertension can be increased when Bexitrol is combined with 2,5-Dimethoxy-4-ethylthioamphetamine. 4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Bexitrol is combined with 4-Bromo-2,5-dimethoxyamphetamine. 4-Methoxyamphetamine The risk or severity of hypertension can be increased when Bexitrol is combined with 4-Methoxyamphetamine. 5-methoxy-N,N-dimethyltryptamine The risk or severity of hypertension can be increased when Bexitrol is combined with 5-methoxy-N,N-dimethyltryptamine. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline The risk or severity of adverse effects can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Bexitrol.

Animal data

  • Oral administration of Bexitrol to pregnant rabbits caused teratogenicity characteristic of beta-adrenoceptor stimulation at maternal doses approximately 50 times maximum recommended human daily inhaled dose (MRHDID) on an AUC basis

Fluticasone-Bexitrol S >

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • wheezing, choking, or other breathing problems after using this medicine;
  • fever, chills, cough with mucus, feeling short of breath;
  • chest pain, fast or irregular heartbeats, severe headache, pounding in your neck or ears;
  • tremors, nervousness;
  • sores or white patches in your mouth or throat, trouble swallowing;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
  • signs of a hormonal disorder--worsening tiredness or muscle weakness, feeling light-headed, nausea, vomiting.

Fluticasone can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

Common side effects may include:

  • headache, muscle pain, bone pain, back pain;
  • nausea, vomiting;
  • throat irritation;
  • cold symptoms such as stuffy nose, sneezing, sore throat; or
  • ongoing cough, hoarseness or deepened voice.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Two multicenter, 12-week, controlled trials have evaluated twice-daily doses of SEREVENT DISKUS in subjects aged 4 to 11 years with asthma. Table 2 includes all events (whether considered drug-related or nondrug-related by the investigator) that occurred at a rate of 3% or greater in the group receiving SEREVENT DISKUS and were more common than in the placebo group.

Table 2: Adverse Reaction Incidence in Two 12-Week Pediatric Clinical Trials in Subjects With Asthma Adverse Event Percent of Subjects Placebo (n = 215) SEREVENT DISKUS 50 mcg Twice Daily (n = 211) Albuterol Inhalation Aerosol 200 mcg 4 Times Daily (n = 115) Ear, nose, and throat Ear signs and symptoms 3 4 9 Pharyngitis 3 6 3 Neurological Headache 14 17 20 Respiratory Asthma 2 4

The following events were reported at an incidence of greater than 1% in the Bexitrol group and with a higher incidence than in the albuterol and placebo groups: gastrointestinal signs and symptoms, lower respiratory signs and symptoms, photodermatitis, and arthralgia and articular rheumatism.

In clinical trials evaluating concurrent therapy of Bexitrol with inhaled corticosteroids, adverse events were consistent with those previously reported for Bexitrol, or with events that would be expected with the use of inhaled corticosteroids.

Bexitrol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.

Is Bexitrol safe to take if I'm pregnant or breastfeeding?

Adequate studies of Bexitrol during pregnancy have not been done. In some, but not all, pregnant animal models exposure to very high doses of oral Bexitrol has led to offspring with birth defects. The concentrations of Bexitrol in the blood after these very high doses, however, were much higher than the concentrations observed after inhalation. Bexitrol inhalation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

In rats, Bexitrol is excreted in milk. Therefore, caution should be exercised when Bexitrol is administered to nursing women.

Fluticasone-Bexitrol Interactions

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using a steroid such as fluticasone.

Do not use a second inhaled bronchodilator unless your doctor tells you to. This includes formoterol (Perforomist, Symbicort, Bevespi, Dulera), arformoterol (Brovana), indacaterol (Arcapta), olodaterol (Striverdi, Stiolto Respimat), Bexitrol (Serevent), or vilanterol (Breo Ellipta, Anoro Ellipta).

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially:

  • antifungal medicine; or
  • medicine to treat HIV or AIDS.

This list is not complete and many other drugs may affect fluticasone and Bexitrol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

home drugs a-z list Serevent Diskus(Bexitrol Xinafoate) side effects drug center

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Serevent Diskus (Bexitrol xinafoate) is a bronchodilator used to prevent asthma attacks. Serevent Diskus will not treat an asthma attack that has already begun. Serevent Diskus is also used to treat chronic obstructive pulmonary disease (COPD) including emphysema and chronic bronchitis. Common side effects of Serevent Diskus include:

Many people using Serevent Diskus do not have serious side effects. Seek immediate medical attention if you have rare but very serious side effects of Serevent Diskus including:

  • chest pain,
  • fast/slow/irregular heartbeat,
  • severe dizziness,
  • fainting, or
  • seizures.

Serevent inhalations should not be used more often than prescribed (twice per day) and proper techniques of inhalation closely followed. Serevent may interact with diuretics (water pills), antibiotics, antifungal medications, beta-blockers, antidepressants, HIV or AIDS medications, MAO inhibitors, caffeine, diet medicines, decongestants, aminophylline, theophylline, and others. Tell your doctor all medications you use. Serevent should be used only when prescribed during pregnancy. It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Serevent Diskus (Bexitrol xinafoate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Generic Name: Bexitrol (sal ME te role)Brand Name: Serevent Diskus

Medically reviewed by Drugs.com. Last updated on May 15, 2019.

Long-acting Bronchodilators (LABAs).

Bexitrol and formoterol that have been evaluated in children. In the USA, Bexitrol delivered by metered-dose inhaler (MDI) has been approved for children aged 12 and older; and by dry powder inhaler (DPI) for those 4 years and older; and formoterol has been approved for 5 years and older. Bexitrol has a delayed (10–15 min) onset of action but the duration of 12–18 hours vs 3–6 hours for albuterol. Formoterol has a similar onset of action to short-acting bronchodilators. Meta-analyses of trials in patients 12 years and older report greater benefit in improving symptoms, exacerbations and lung function with addition of LABA than with ICS dose. 118,119 The bronchodilating effect of LABAs, however, may diminish with time. 120 Use of LABAs as monotherapy is contraindicated.

In patients 12 years of age and older, the ICS-LABA combination therapy may permit reductions in ICS without worsening of control. LABAs should therefore be used as adjunctive therapy in patients older than 5 years not controlled on low-dose ICS. In EPR-3, equal consideration can be given to increasing ICS dose to the addition of a LABA or LTRA to ICS.

HIV drugs

Taking certain HIV drugs with fluticasone/Bexitrol may increase the amount of fluticasone/Bexitrol in your body. This may cause more side effects. Examples of these drugs include:

  • ritonavir
  • atazanavir
  • indinavir
  • nelfinavir
  • saquinavir

1.5 Uses and Applications

Bexitrol xinafoate has been developed as a potent β2-adrenoceptor agonist having the desired pharmacological profile of a long-acting bronchodilator . Bexitrol xinafoate as a long-acting β-agonist (LABA) is prescribed for the treatment of asthma and chronic obstructive pulmonary disease . The principal action of Bexitrol, like other β2-agonists, is to relax airway smooth muscle by stimulating β2-adrenergic receptors. This increases the intracellular messenger cyclic AMP that is responsible for the control of smooth muscle tone . Thus, activation of the β2-adrenergic receptor results directly in bronchodilation. Muscarinic antagonists also facilitate bronchodilation but work by competing with acetylcholine for muscarinic receptors . Bexitrol xinafoate as LABA with a 12-h duration of action showed positive experience in asthma , providing improvements in bronchodilator efficacy and patient outcomes compared with short-acting β-agonist (SABA), which have duration of action of only 4–6 h . Bexitrol is usually prescribed only for severe persistent asthma following previous treatment with SABA, such as salbutamol and is prescribed concurrently with an inhaled corticosteroid (ICS), such as fluticasone . The combination of the LABA and the ICS has been shown to have superior efficacy to either component given separately , a higher dose of ICS alone , or a combination of ICS and a leukotriene antagonist or theophylline .


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