Asmalair tablets


  • Active Ingredient: Montelukast
  • 10 mg, 5 mg, 4 mg
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What is Asmalair?

The active ingredient of Asmalair brand is montelukast. Montelukast is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.

Used for

Asmalair is used to treat diseases such as: Allergic Rhinitis, Asthma, Asthma, Maintenance, Bronchospasm Prophylaxis, COPD.

Side Effect

Possible side effects of Asmalair include: skin rash, encrusted, scaly and oozing; lack or loss of strength; Agitation; feeling sad or empty; breathing problems; Acid or sour stomach; unpleasant breath odor; fast, irregular, pounding, or racing heartbeat or pulse.

How to Buy Asmalair tablets online?

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How to store Asmalair

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all patients taking this medicine (Asmalair tablets):

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs or symptoms of depression, suicidal thoughts, emotional ups and downs, abnormal thinking, anxiety, or lack of interest in life.
  • Signs of a very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.
  • Hallucinations (seeing or hearing things that are not there).
  • Memory problems or loss.
  • Feeling confused, not able to focus, or change in behavior.
  • Strange or odd dreams.
  • Trouble sleeping.
  • Trouble speaking.
  • Restlessness.
  • Sleepwalking.
  • Shakiness.
  • Trouble controlling body movements.
  • Seizures.
  • Trouble breathing that is new or worse.
  • Fever.
  • Flu-like signs.
  • Sinus pain.
  • Chest pain.
  • A heartbeat that does not feel normal.
  • Any unexplained bruising or bleeding.
  • A burning, numbness, or tingling feeling that is not normal.
  • Ear pain.
  • Muscle or joint pain.
  • Swelling.

Asmalair is rapidly absorbed following oral administration. After administration of the 10-mg filmcoated tablet to fasted adults, the mean peak Asmalair plasma concentration (Cmax) is achieved in 3 to 4 hours (Tmax). The mean oral bioavailability is 64%. The oral bioavailability and Cmax are not influenced by a standard meal in the morning.

For the 5-mg chewable tablet, the mean Cmax is achieved in 2 to 2.5 hours after administration to adults in the fasted state. The mean oral bioavailability is 73% in the fasted state versus 63% when administered with a standard meal in the morning.

For the 4-mg chewable tablet, the mean Cmax is achieved 2 hours after administration in pediatric patients 2 to 5 years of age in the fasted state.

The 4-mg oral granule formulation is bioequivalent to the 4-mg chewable tablet when administered to adults in the fasted state. The co-administration of the oral granule formulation with applesauce did not have a clinically significant effect on the pharmacokinetics of Asmalair. A high fat meal in the morning did not affect the AUC of Asmalair oral granules; however, the meal decreased Cmax by 35% and prolonged Tmax from 2.3 ± 1.0 hours to 6.4 ± 2.9 hours.

The safety and efficacy of SINGULAIR in patients with asthma were demonstrated in clinical trials in which the 10-mg film-coated tablet and 5-mg chewable tablet formulations were administered in the evening without regard to the time of food ingestion. The safety of SINGULAIR in patients with asthma was also demonstrated in clinical trials in which the 4-mg chewable tablet and 4-mg oral granule formulations were administered in the evening without regard to the time of food ingestion. The safety and efficacy of SINGULAIR in patients with seasonal allergic rhinitis were demonstrated in clinical trials in which the 10-mg film-coated tablet was administered in the morning or evening without regard to the time of food ingestion.

The comparative pharmacokinetics of Asmalair when administered as two 5-mg chewable tablets versus one 10-mg film-coated tablet have not been evaluated.

Asmalair is a potent inhibitor of CYP2C8 in vitro. However, data from a clinical drug-drug interaction study involving Asmalair and rosiglitazone (a probe substrate representative of drugs primarily metabolized by CYP2C8) in 12 healthy individuals demonstrated that the pharmacokinetics of rosiglitazone are not altered when the drugs are coadministered, indicating that Asmalair does not inhibit CYP2C8 in vivo. Therefore, Asmalair is not anticipated to alter the metabolism of drugs metabolized by this enzyme (e.g., paclitaxel, rosiglitazone, and repaglinide). Based on further in vitro results in human liver microsomes, therapeutic plasma concentrations of Asmalair do not inhibit CYP 3A4, 2C9, 1A2, 2A6, 2C19, or 2D6.

Q: If you have cataracts, should you use Singular?

A: Singulair (Asmalair) is a leukotriene-receptor antagonist used to treat asthma, seasonal allergic rhinitis, perennial allergic rhinitis, and prevention of exercise-induced bronchospasm. Common side effects of Singulair include cough, dizziness, headache, and upset stomach. There are no contraindications or warnings against the use of Singulair in patients with cataracts. Having cataracts is not a reason by itself to avoid Singulair unless your doctor tells you otherwise. Your doctor will help you determine what medication is best for you. Laura Cable, PharmD

Why it's used

Asmalair oral tablet is used to prevent and treat asthma. It’s also used to treat seasonal and year-round allergies.

Asmalair is also used to prevent exercise-induced bronchoconstriction (EIB). EIB occurs when the airways in the lungs narrow during or after exercise. This can cause shortness of breath, wheezing, or cough.


Cholestatic jaundice arose after 10 months of Asmalair therapy. No other cause of liver disease or jaundice was identified and he improved once Asmalair was stopped, while other antiasthma medications (metered inhalants) were continued. The latency to onset was unusual and the clinical presentation was that of bland, canalicular cholestasis similar to what occurs with anabolic steroid use. However, this patient denied use of other medications.

Michael Stewart, Reviewed by Sid Dajani | Last edited 17 Sep 2018 | Certified by The Information Standard

Take Asmalair regularly every evening.

Your doctor will prescribe a reliever inhaler for you to use in case you have an asthma attack. Make sure that you keep it with you all the time.

The most common side-effects of Asmalair are respiratory infections, tummy (abdominal) pain and headache.

ВїCГіmo se debe usar este medicamento?

La presentaciГіn del Asmalair es en tabletas, tabletas masticables y en grГЎnulos para tomarlo por vГ­a oral. Asmalair se toma usualmente una vez al dГ­a, con o sin alimentos. Cuando se usa Asmalair para tratar el asma, se debe tomar por las noches. Cuando se usa Asmalair para prevenir dificultades respiratorias al hacer ejercicio, se debe tomar al menos 2 horas antes de hacer ejercicio. Si estГЎ tomando Asmalair una vez al dГ­a de forma regular, o si tomГі una dosis de Asmalair durante las Гєltimas 24 horas, no debe tomar otra dosis antes de hacer ejercicio. Cuando se usa Asmalair para tratar rinitis alГ©rgica, se puede tomar a cualquier hora del dГ­a. Tome Asmalair aproximadamente a la misma hora todos los dГ­as. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta mГ©dica y pida a su mГ©dico o farmacГ©utico que le expliquen cualquier parte que no comprenda. Tome Asmalair exactamente como se indica. No tome una cantidad mayor o menor del medicamento, ni lo tome con mГЎs frecuencia de lo que indica la receta de su mГ©dico.

Si le estГЎ dando los grГЎnulos a su hijo, no debe abrir la bolsa de aluminio hasta que su hijo estГ© listo para tomar el medicamento. Hay varias formas en las que puede darle los grГЎnulos a su hijo, asГ­ que elija la que funcione mejor para su hijo y para usted. Puede verter todos los grГЎnulos directamente del paquete en la boca de su hijo para que los trague de inmediato. TambiГ©n puede verter todo el paquete de grГЎnulos en una cuchara limpia y colocar la cuchara de medicamento en la boca de su hijo. Si lo prefiere, puede mezclar todo el paquete de grГЎnulos en 1 cucharadita (5 ml) de fГіrmula de bebГ© frГ­a o a temperatura ambiente, leche materna, purГ© de manzana, papilla de zanahoria, helado o arroz. No debe mezclar los grГЎnulos con ningГєn otro alimento o lГ­quido, pero su hijo puede tomar cualquier lГ­quido justo despuГ©s de haber tomado los grГЎnulos. Si mezcla los grГЎnulos con uno de los alimentos o bebidas permitidos, use las mezclas en un tГ©rmino de 15 minutos. No almacene mezclas no utilizadas de alimento, fГіrmula o leche materna y el medicamento.

No use Asmalair para tratar los sГ­ntomas de un ataque repentino de asma. Su mГ©dico le recetarГЎ un inhalador de acciГіn breve (rescate) para que lo use durante los ataques. Hable con su mГ©dico sobre cГіmo tratar los sГ­ntomas de un ataque repentino de asma. Si sus sГ­ntomas de asma empeoran o si tiene ataques de asma mГЎs a menudo, asegГєrese de llamar a su mГ©dico.

Si estГЎ tomando Asmalair para tratar el asma, continГєe tomando o usando todos los demГЎs medicamentos que su mГ©dico le haya recetado para tratar el asma. No deje de tomar ninguno de sus medicamentos ni cambie la dosis de ninguno de sus medicamentos, a menos que su mГ©dico le indique que debe hacerlo. Si la aspirina empeora su asma, no tome aspirina ni ningГєn otro medicamento antiinflamatorio no esteroideo (AINE) durante su tratamiento con Asmalair.

El Asmalair controla los sГ­ntomas del asma y de la rinitis alГ©rgica, pero no cura estas afecciones. ContinГєe tomando Asmalair incluso si se siente bien. No deje de tomar Asmalair con receta mГ©dica sin hablar con su mГ©dico.

Pida a su farmacГ©utico o mГ©dico una copia de la informaciГіn del fabricante para el paciente.

How it works

Asmalair belongs to a class of drugs called leukotriene receptor antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Leukotriene receptor antagonists help decrease inflammation and nasal congestion. This can help prevent reactions to triggers by keeping the airways to your lungs open. This helps improve symptoms of asthma as well as seasonal and year-round allergies. It also helps prevent breathing problems during or after exercise.

Asmalair oral tablet doesn’t cause drowsiness, but it can cause other side effects.

Asmalair is extensively metabolized. In studies with therapeutic doses, plasma concentrations of metabolites of Asmalair are undetectable at steady state in adults and pediatric patients.

In vitro studies using human liver microsomes indicate that CYP3A4, 2C8, and 2C9 are involved in the metabolism of Asmalair. At clinically relevant concentrations, 2C8 appears to play a major role in the metabolism of Asmalair.

What is Asmalair, and how does it work (mechanism of action)?

Asmalair is an oral leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis (hay fever). Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy). They are formed by cells, released, and then bound to other cells that cause inflammation. It is the binding to other cells that stimulates the cells to cause inflammation. Asmalair works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes to the cells that cause inflammation. Unlike zafirlukast, Asmalair does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs. Therefore, unlike zafirlukast, Asmalair is not expected to affect the elimination of other drugs. The safety and effectiveness of Asmalair has been demonstrated in children as young as 6 months of age. It was approved by the FDA in 1998.

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your (or your child's) progress.
  • Asmalair will not give you immediate relief if you are having an asthma attack. Your doctor will prescribe a reliever inhaler for you to use if this happens. Make sure that you keep it with you all the time in case you need to use it.
  • If you find that your asthma symptoms are getting worse, or that you need to use the reliever inhaler more regularly than usual, please contact your doctor or nurse for advice straightaway.
  • Do not smoke. Smoking causes severe irritation and damage to the lungs. It will make your condition worse and will reduce the beneficial effects of your medication.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take. Some anti-inflammatory painkillers and aspirin can make asthma symptoms worse in some people.

In the US, Asmalair (Asmalair systemic) is a member of the drug class leukotriene modifiers and is used to treat Allergic Rhinitis, Asthma, Asthma - Maintenance, Bronchospasm Prophylaxis and COPD.


Asmalair (Singulair) is a drug prescribed for the treatment of asthma and hay fever (seasonal allergic rhinitis). Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.

Generic Name: Asmalair Tablets (mon te LOO kast)Brand Name: Singulair

Medically reviewed by Last updated on Jul 20, 2019.

Q: Is it possible to be allergic to Singulair?

A: It is possible for a person to be allergic to Singulair (Asmalair). Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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