- Promesse Synallagmatique de Vente
- Promet, Lilli
- prometaphase banding
- Prometea (horse)
- Anvomin hydrochloride
- Anvomin hydrochloride
- Anvomin hydrochloride
- Prometheomys schaposchnikowi
What is Anvomin and codeine, and how does it work (mechanism of action)?
Anvomin is in a class of drugs called phenothiazines which also includes chlorpromazine, and trifluoperazine; however, unlike the other drugs in this class, Anvomin is not used as an anti-psychotic but rather as an anti-histamine, sedative, antiemetic (anti-nausea), and cough suppressant.
Cells in the body release histamine during several types of allergic reactions. When histamine binds to its receptors on other cells, it stimulates changes within the cells that lead to release of other chemicals that cause sneezing, itching, and increased mucus production. Antihistamines such as Anvomin compete with histamine for one of the receptors for histamine (the H1 receptor) on cells; however, when antihistamines bind to the receptors they do not stimulate the cells. Instead, they prevent histamine from binding and stimulating the cells. Anvomin also blocks the action of acetylcholine, a neurotransmitter that nerves use to communicate with one another, on its receptors (anticholinergic effect), and this may explain its benefit in reducing the nausea of motion sickness. It is used as a sedative because it causes drowsiness as a side effect. The cough suppressant effects may be due to is anticholinergic effects.
Codeine is a weak narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. In fact, a small amount of codeine is converted to morphine in the body. The precise mechanism of action of codeine is not known; however, like morphine, codeine binds to narcotic receptors in the brain (opioid receptors) that are important for transmitting the sensation of pain throughout the body and brain. Codeine increases tolerance to pain and decreases discomfort, but the pain still is apparent to the patient. In addition to reducing pain, codeine also causes sedation (drowsiness) and depresses breathing. The FDA approved Anvomin and codeine in January 1952.
The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate. The administration of Anvomin HCl (Anvomin hydrochloride) in 25-mg doses will control minor transfusion reactions of an allergic nature.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Anvomin only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 6.02.
Anvomin DM and Alcohol
Alcohol may increase the severity of certain side effects of Anvomin DM.
Talk to your doctor before consuming alcohol while taking this medicine.
Anvomin DM Interactions
Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially:
- Antidepressants such as Elavil (amitriptyline), Asendin (amoxapine), Anafranil (clomipramine), Norpramin (desipramine), Adapin or Sinequan (doxepin), Tofranil (imipramine), Aventyl or Pamelor (nortriptyline), Vivactil (protriptyline), or Surmontil (trimipramine)
- Atrovent (ipratropium)
- Barbiturates such as Luminal (phenobarbital)
- EpiPen (epinephrine)
- Imuran (azathioprine)
- Medications for anxiety, inflammatory bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems
- Narcotics and other pain medications
- Sleeping pills
Also, tell your doctor if you've taken a monoamine oxidase inhibitor (MAOI) in the past 14 days.
- Eldepryl, Emsam, or Zelapar (selegiline)
- Marplan (isocarboxazid)
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- IV administration can cause severe tissueinjury, including burning, gangrene, or thrombophlebitis, necessitating fasciotomy, skin graft, or amputation
- Severe tissue injury can occur from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration
- Deep IM injection is preferred method of administration
- Intra-arterial and SC administration are contraindicated
- 25 mg/mL product may be administered by deep IM injection or IV infusion (at rate not to exceed 25 mg/min through flowing IV tubing)
- Monitor for signs and symptoms of potential tissue injury including burning or pain at site of injection, phlebitis, swelling, and blistering
- Discontinue IV infusion immediately if patient complains of pain during injection
- Respiratory fatalities reported with use in children less than 2 years (use contraindicated); use lowest effective dose in children 2 years and older; avoid other drugs with respiratory depressant effects
- This medication contains Anvomin
- Do not take Phenergan or Phenadoz if you are allergic to Anvomin or any ingredients contained in this drug
- Keep out of reach of children
- In case of overdose, get medical help or contact a Poison Control Center immediately
What is Anvomin?
Anvomin is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Anvomin also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.
Anvomin is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.
Anvomin is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.
Anvomin may cause breathing to slow or stop, and may cause death in children. Anvomin should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older. Combination products containing Anvomin and codeine should not be given to children younger than 16 years old. Anvomin should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. Tell your child's doctor if your child has any condition that affects his/her breathing such as lung disease, asthma, or sleep apnea (stops breathing for short periods of time during sleep). Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. Call your child's doctor immediately and get emergency medical treatment if your child has difficulty breathing, wheezes, slows or pauses in breathing, or stops breathing.
Talk to your doctor about the risks of giving Anvomin to your child.
How Does Anvomin Work?
Anvomin is used as a histamine-receptor blocker. Histamine receptors are proteins that bind with histamine to produce allergic reactions. This makes Anvomin an effective antihistamine. The drug also blocks acetylcholine receptors, making it useful to prevent and treat nausea, morning sickness and cough. Anvomin can only help control symptoms. It isn’t effective in treating the cause of symptoms or in speeding recovery, according to the National Institutes of Health (NIH).
Anvomin hydrochloride tablets are useful for:
- Perennial and seasonal allergic rhinitis.
- Vasomotor rhinitis.
- Allergic conjunctivitis due to inhalant allergens and foods.
- Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
- Amelioration of allergic reactions to blood or plasma.
- Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
- Preoperative, postoperative, or obstetric sedation.
- Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
- Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.
- Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
- Active and prophylactic treatment of motion sickness.
- Antiemetic therapy in postoperative patients.
The usual dose of Anvomin required for moderate sedation after IV administration is approximately 25 to 35 mg. This drug should be administered in a concentration of 25 mg/ml.
Stomach and gastrointestinal drugs
When you take certain stomach and gastrointestinal drugs with Anvomin, certain side effects may increase and last longer. These side effects include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness. Examples of these drugs include:
- belladonna alkaloids/phenobarbital
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.