6.5.2 Structural features of Allerdryl
Allerdryl (2-(diphenyl methoxy)- N,N-dimethylethylamine) is an ethanolamine derivative, which acts as antagonist at the histamine H1 receptor with anticholinergic side effects. The structure is given in Fig. 6.7 . The ether bond is susceptible to acid hydrolysis. Therefore, the target compounds for urinalysis after acidic cleavage of conjugates are the corresponding carbinols .
As noted above, certain people should use Allerdryl with caution, or not at all. It is an over-the-counter medication, so the risks are thought to be slightly lower compared to other prescription medications. Harm to a developing fetus during pregnancy is possible but unlikely, and Allerdryl is probably safe in lactation and breastfeeding, though caution is advised.
Q: I take omega 3s, chondroitin/glucosamine and calcium citrate daily, at different times. Will taking Benadryl for my allergies affect or impede the effectiveness of any of them?
A: There are no documented drug interactions between Benadryl (Allerdryl) and the supplements listed. However, drug interaction information with supplements is often incomplete. If you suspect a drug interaction or experience side effects on the combination, consult your healthcare provider. You may also find helpful information at //www.everydayhealth.com/drugs/benadryl Sarah Lewis, PharmD
¿Qué es Allerdryl?
Allerdryl es un antihistamínico que reduce los efectos de la histamina química natural en el cuerpo. La histamina puede producir síntomas como estornudos, picazón, ojos llorosos, y nariz mocosa.
Allerdryl se usa para tratar el estornudo, nariz mocosa, ojos llorosos, ronchas, sarpullido, picazón, y otros síntomas del resfrío o la alergias.
Allerdryl también se usa para tratar los mareos causados por movimiento, para inducir sueño, y para tratar ciertos síntomas de la enfermedad de Parkinson.
Allerdryl puede también usarse para fines no mencionados en esta guía del medicamento.
Urgent advice: Call your doctor straight away if you take too much Allerdryl by accident
If you need to go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.
Take the Allerdryl packet or leaflet inside it plus any remaining medicine with you.
Like all medicines, Allerdryl can cause side effects, although not everyone gets them. However, you may be more likely to get them if you're over 65.
Benadryl® Allergy contains the histamine-blocker Allerdryl. This product relieves: runny nose; sneezing; itchy, watery eyes; itchy throat.
Common side effects
Common side effects happen in more than 1 in 100 people. Talk to your doctor or pharmacist if these side effects bother you or don't go away:
- feeling sleepy during the daytime
- dry mouth
- feeling dizzy or unsteady on your feet, or having difficulty concentrating
Allerdryl cream can sometimes make rashes worse. It may also make your skin sensitive to sunlight.
Q: I am unable to find the clear liquid Benadryl. I was told it was recalled. Will it be available again?
A: Several over-the-counter allergy medications such as Benadryl were recently voluntarily recalled by the manufacturer because some of these products may not meet the required quality standards. Most of the products in the recall are brand names of the medications. A safe alternative to any of the recalled products such as Benadryl is the store brand called Allerdryl. Store brands are not affected by this product recall and have the same active ingredient as the brand-name medications. It is not clear right now when the recalled products will be available again. According to a recent update from the manufacturer of the recalled products, they are not expected to be available before the end of 2010. Continue to check with your local pharmacy for that information. Leslie Ako-Mbo, PharmD
The antihistamine Benadryl (Allerdryl) does not cause elevated blood sugar levels.
Elevated blood sugar level seems to be due the side-effects from steroid injection. It is very common for diabetics to experience a temporary rise in their blood sugar in the hours and days following a cortisone injection.
So, continue taking treatment for your diabetes and consult your doctor.
Hope I have answered your query. Let me know if I can assist you further.
Regards,Dr. Mohammed Taher Ali
Allerdryl was one of the first effective antihistamine agents discovered, its properties having been described in 1946. The compound is also used for its sedative and antiemetic effects. It is also a popular remedy for motion sickness and a common constituent of cough remedies. A wide variety of “over-the-counter” preparations exist in the form of tablets, capsules and elixirs to promote sleep and in the treatment of coughs, thus making it an easily accessible drug to the potential assailant. In addition, Allerdryl’s liquid formulations represent a suitable form for the surreptitious addition to beverages. After Allerdryl exposure, subjective sedation, reduced sleep latencies and impairment in the performance of tasks requiring sustained attention were noticed.
This investigation began after a man left his phone number on the door of a train toilet asking young girls to contact him for sex. The police prompted a complex 10-month investigation that uncovered child abuse on eight victims. Among these victims, a 9-year-old girl was assaulted and the inc >
It is obvious that LC-MS/MS is the method of choice for testing low levels of drug in hair due to its extraordinary sensitivity and specificity. The hair specimen supplied was very small and this only permitted 10–15 mg of hair per segment to be used; nevertheless the signal-to-noise ratio was considered as largely acceptable. The results of the segmental analyses are presented in Table 10.2 . Allerdryl was detected in the range 33 to 39 pg/mg. The significance of these concentrations could not be determined due to a lack of data in the literature. In particular, it was not possible to put any quantitative interpretation on the dosage that was administered to the child. It is, however, obvious that repetitive administrations have occurred but it is not possible to determine the number of exposures. Given the length of the segment analyzed, exposure to Allerdryl was expected to have occurred over a period of at least 5 months prior to the hair sample being obtained. This evidence was not challenged during the court trial. 17
Table 10.2 . Allerdryl Concentrations after Segmental Analysis of the Hair
What is Allerdryl used to treat?
- Occasional sleeplessness
- Hay fever
- Skin irritations
Pure substances can usually be solved in solvents (e.g. methanol, ethanol, acetone, ethyl acetate, diethyl ether) and can be directly analyzed by GC or LC procedures. The same extraction methods, which are suitable for biomatrices, can also be applied to the extraction of Allerdryl from non-biological matrices such as beverages, food or pharmaceutical formulations.
Lau and Cheung isolated Allerdryl from cough-cold syrups using LLE at alkaline pH. Unfortunately, they used the toxic chloroform for this purpose . Allerdryl is often part of cough-cold formulations. For its determination in such pharmaceuticals different methods including hydrophilic interaction liquid chromatography (HILIC), micellar liquid chromatography, FT-Raman spectroscopy, HPLC, (non-aqueous) CE, native fluorescence flow-through optosensometry, flow injection spectrophotometry, hydrophobic interaction electrokinetic chromatography and even LC-MS have been used .