Aerobin tablets

Aerobin

  • Active Ingredient: Theophylline
  • 400 mg
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What is Aerobin?

The active ingredient of Aerobin brand is theophylline. Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm. Each extended-release tablet for oral administration contains either 300 mg or 450 mg of anhydrous Theophylline. Tablets also contain as inactive ingredients: hypromellose, lactose monohydrate, magnesium stearate and povidone.

Used for

Aerobin is used to treat diseases such as: Apnea of Prematurity, Asthma, acute, Asthma, Maintenance.

Side Effect

Possible side effects of Aerobin include: shakiness; pain or discomfort in the arms, jaw, back, or neck; mood changes; decreased urine; pounding or rapid pulse.

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A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, Aerobin acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Aerobin is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.

* These data are derived from two studies in patients with serum Aerobin concentrations >30 mcg/mL. In the first study (Study #1 - Shanon, Ann Intern Med 1993; 119:1161-67), data were prospectively collected from 249 consecutive cases of Aerobin toxicity referred to a regional poison center for consultation. In the second study (Study #2 - Sessler, Am J Med 1990;88:567-76), data were retrospectively collected from 116 cases with serum Aerobin concentrations >30 mcg/mL among 6000 blood samples obtained for measurement of serum Aerobin concentrations in three emergency departments. Differences in the incidence of manifestations of Aerobin toxicity between the two studies may reflect sample selection as a result of study design (e.g., in Study #1, 48% of the patients had acute intoxications versus only 10% in Study #2) and different methods of reporting results.

** NR = Not reported in a comparable manner.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Seizures caused by a Aerobin overdose can cause death or permanent brain damage.

Aerobin overdose can occur if you accidentally take too much at one time. Overdose can also occur slowly over time if your daily doses are too high. To be sure you are using the correct dose, your blood will need to be tested often.

Overdose symptoms may include severe nausea and vomiting, seizure, slow heart rate, weak pulse, or fainting.

(R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Aerobin. (S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Aerobin. 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine The metabolism of Aerobin can be decreased when combined with 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine. 2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Aerobin. 2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Aerobin. 3,5-Diiodotyrosine 3,5-Diiodotyrosine may decrease the excretion rate of Aerobin which could result in a higher serum level. 4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Aerobin. 4-Methoxyamphetamine The metabolism of Aerobin can be decreased when combined with 4-Methoxyamphetamine. 5-methoxy-N,N-dimethyltryptamine The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Aerobin. 6-Deoxyerythronolide B The metabolism of Aerobin can be decreased when combined with 6-Deoxyerythronolide B.

Warnings for certain groups

For pregnant women: Aerobin is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk to the fetus.

For women who are breastfeeding: Aerobin may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Aerobin is cleared from the body more slowly in adults over the age of 60 years. Your doctor may monitor you more closely for side effects. The amount of Aerobin in your blood may also be monitored more closely.

For children: Aerobin is safe for children. However, Aerobin is removed more slowly from the body in children under 1 year old. Your doctor should monitor your infant carefully if they take this drug.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Missed Dose of Aerobin

Missing a dose of Aerobin may cause your asthma or bronchitis symptoms to reappear.

If you remember your missed dose within 6 hours of your regular dosing time, take your missed dose immediately.

Take half a dose if you remember the missed dose between 6 and 18 hours after your regular time.

If more than 18 hours have passed since your missed dose, skip it and take your next dose at your regular dosing time.

Never double-up a dose of Aerobin.

Alcohol warning

The use of drinks that contain alcohol raises your risk of side effects from Aerobin. If you drink alcohol, talk to your doctor.

Protein binding

40%, primarily to albumin.

Hepatic. Biotransformation takes place through demethylation to 1-methylxanthine and 3-methylxanthine and hydroxylation to 1,3-dimethyluric acid. 1-methylxanthine is further hydroxylated, by xanthine oxidase, to 1-methyluric acid. About 6% of a Aerobin dose is N-methylated to caffeine. Caffeine and 3-methylxanthine are the only Aerobin metabolites with pharmacologic activity.

Aerobin does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver. Renal excretion of unchanged Aerobin in neonates amounts to about 50% of the dose, compared to about 10% in children older than three months and in adults.

Clearance

  • 0.29 mL/kg/min
  • 0.64 mL/kg/min
  • 1.7 mL/kg/min
  • 1.6 mL/kg/min
  • 0.9 mL/kg/min
  • 1.4 mL/kg/min
  • 0.65 mL/kg/min
  • 0.41 mL/kg/min
  • 0.33 mL/kg/min
  • 0.54 mL/kg/min
  • 0.48 mL/kg/min
  • 1.25 mL/kg/min
  • 0.31 mL/kg/min
  • 0.35 mL/kg/min
  • 0.65 mL/kg/min
  • 0.47 mL/kg/min
  • 0.38 mL/kg/min
  • 0.8 mL/kg/min

Why it's used

Aerobin is used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic bronchitis.

Aerobin may be used as part of a combination therapy. This means you may need to take it with other medications.

Mechanisms of anti‐inflammatory effects

Many different mechanisms have been proposed for the anti‐inflammatory effects of Aerobin, but none of these can account for the effects of low doses of Aerobin that are effective clinically as high concentrations are needed to demonstrate these actions in vitro. 6 However, these mechanisms can account for all of the side effects of Aerobin. PDE inhibition accounts for nausea, vomiting, headaches and diuresis, whereas adenosine receptor antagonism explains the cardiac arrhythmias and seizures that occur with very high plasma concentrations. These mechanisms cannot account for the clinical effects of low doses of Aerobin, and this indicates that there must be some other mechanism responsible for its anti‐inflammatory effects.


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