Salvacam capsules

Salvacam

  • Active Ingredient: Piroxicam
  • 20 mg
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What is Salvacam?

The active ingredient of Salvacam brand is piroxicam. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. It is slightly soluble in alcohol and in aqueous solutions. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). The inactive ingredients in Piroxicam include: Blue 1, Red 3, lactose, magnesium stearate, sodium lauryl sulfate, starch.

Used for

Salvacam is used to treat diseases such as: Frozen Shoulder, Osteoarthritis, Pain, Rheumatoid Arthritis, Temporomandibular Joint Disorder.

Side Effect

Possible side effects of Salvacam include: back or leg pains; inability to sit still; indigestion; irritability; Feeling of constant movement of self or surroundings.

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Salvacam (PIRO) is a nonselective NSAID used for its anti-inflammatory properties as well and for its value as a chemopreventive and antitumor agent.

Salvacam side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Stop using Salvacam and call your doctor at once if you have:

severe headache, blurred vision, pounding in your neck or ears;

heart problems--swelling, rapid weight gain, feeling short of breath;

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

upset stomach, heartburn, loss of appetite, stomach pain, nausea, vomiting;

itching, rash; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

COMMON BRAND(S): Feldene

GENERIC NAME(S): Salvacam

OTHER NAME(S): Salvacam Capsule

Nonsteroidal anti-inflammatory drugs (including Salvacam) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.

Stop taking Salvacam and get medical help right away if you notice any of these rare but serious side effects: black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, slurred speech, sudden vision changes.

Talk to your doctor or pharmacist about the benefits and risks of taking this drug.

Salvacam is used to reduce pain, swelling, and joint stiffness from arthritis. Reducing these symptoms helps you do more of your normal daily activities. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

El Salvacam puede provocar efectos secundarios. DГ­gale a su doctor si cualquiera de estos sГ­ntomas se vuelve severo o si no desaparece:

  • diarrea
  • estreГ±imiento (constipaciГіn)
  • gases
  • cefalea (dolor de cabeza)
  • mareos
  • pitido en los oГ­dos

Hematologic Toxicity

Anemia has occurred in NSAID-treated patients. This may be due to occult or gross blood loss, fluid retention, or an incompletely described effect on erythropoiesis. If a patient treated with Salvacam has any signs or symptoms of anemia, monitor hemoglobin or hematocrit.

NSA > .

Indications and clinical uses

Salvacam is primarily used to treat pain and inflammation associated with arthritis and other musculoskeletal conditions. It is not used as much for these conditions as other approved NSAIDs for animals. Another use in dogs and cats has been as an adjunct for treating cancer. This use is based on reports of its activity for treating or suppressing some tumors, including transitional cell carcinoma of the bladder, squamous cell carcinoma, and mammary adenocarcinoma. (This effect is not unique to Salvacam, as other NSAIDs also may have antitumor properties.) Salvacam has been used in combination with cisplatin to treat oral malignant melanoma and oral squamous cell carcinoma in dogs (0.3 mg/kg).

Background

Salvacam (pir ox' i kam) belongs to the oxicam family, which is a class of enolic acids structurally unrelated to other NSAIDs. Salvacam, like other NSAIDs, acts through inhibition of tissue cyclooxygenases (Cox-1 and -2) leading to a decrease in synthesis of pro-inflammatory prostaglandins, which are potent mediators of pain and inflammation. Salvacam has analgesic as well as antipyretic and antiinflammatory activities. Salvacam was approved for use in the United States in 1982 and is still widely used, with several million prescriptions filled yearly. Current indications include rheumatoid arthritis and osteoarthritis. Salvacam is available as capsules of 10 and 20 mg in several generic forms as well as under brand names such as Feldene, Novo-Pirocam and Nu-Pirox. The recommended dose is 10 to 20 mg orally once daily. Salvacam is available by prescription only. Other oxicam NSAIDs include meloxicam, tenoxicam, and droxicam, the latter two being available in other countries, but not the United States. As with other NSAIDs, Salvacam is generally well tolerated, but side effects can include headache, dizziness, somnolence, dyspepsia, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In patients taking Salvacam or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1% to 10% of patients are:

Cardiovascular System: Edema

Digestive System: Anorexia, abdominal pain, constipation, diarrhea, flatulence, nausea, vomiting

Nervous System: Dizziness, headache, vertigo

Skin and Appendages: Pruritus, rash

Special Senses: Tinnitus

Additional adverse experiences reported occasionally include:

Cardiovascular System: Palpitations

Digestive System: Stomatitis Nervous System: Drowsiness Special Senses: Blurred vision

Salvacam pharmacokinetics have been investigated in patients with renal insufficiency. Studies indicate patients with mild to moderate renal impairment may not require dosing adjustments. However, the pharmacokinetic properties of Salvacam in patients with severe renal insufficiency or those receiving hemodialysis are not known.

How to store Salvacam

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Disease-modifying anti-inflammatory drug

Taking methotrexate with Salvacam can lead to dangerous levels of methotrexate in your body. This may cause side effects such as nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Premature Closure Of Fetal Ductus Arteriosus

Salvacam may cause premature closure of the fetal ductus arteriosus. Avoid use of NSAIDs, including FELDENE, in pregnant women starting at 30 weeks of gestation (third trimester) .

Generic Name: Salvacam (peer OX i kam)Brand Name: Feldene

Medically reviewed by Drugs.com on Aug 13, 2019 – Written by Cerner Multum

What Are Side Effects Associated with Using Salvacam ?

Side effects of Salvacam include:

Less common side effects of Salvacam include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

When Salvacam was administered with aspirin, its protein binding was reduced, although the clearance of free FELDENE was not altered. Plasma levels of Salvacam were decreased to approximately 80% of their normal values when FELDENE was administered (20 mg/day) in conjunction with aspirin (3900 mg/day). The clinical significance of this interaction is not known .


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