Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Allergic reaction. Symptoms can include:
- skin rash
- itching or hives
- swelling of your face, lips, or tongue
- chest pain
- shortness of breath
- weakness on one side of your body
- slurred speech
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Pirox-CT oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Pirox-CT are listed below.
How should this medicine be used?
Pirox-CT comes as a capsule to take by mouth. It is usually taken once or twice a day. Take Pirox-CT at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Pirox-CT exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not chew or crush them.
Pirox-CT will help control your symptoms but will not cure your condition. It may take 8 to 12 weeks or longer before you feel the full benefit of Pirox-CT.
What Is Pirox-CT and How Does It Work?
Pirox-CT is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis.
Pirox-CT is available under the following different brand names: Feldene.
Dosages of Pirox-CT :
Dose Forms and Strengths
Dosage Considerations – Should be Given as Follows:
Rheumatoid arthritis (including juvenile), osteoarthritis
- 20 mg orally once/day or divided twice daily; no more than 30-40 mg/day
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. Highly Protein Bound Drugs Clinical Impact : Pirox-CT is highly protein bound and, therefore, might be expected to displace other protein bound drugs. Intervention : Physicians should closely monitor patients for a change in dosage requirements when administering Pirox-CT to patients on other highly protein bound drugs. Corticosteroids Clinical Impact : Concomitant use of corticosteroids with Pirox-CT may increase the risk of GI ulceration or bleeding. Intervention : Monitor patients with concomitant use of Pirox-CT with corticosteroids for signs of bleeding .
Pirox-CT (PIRO) is a nonselective NSAID used for its anti-inflammatory properties as well and for its value as a chemopreventive and antitumor agent. It has a much higher potency against COX-1 than COX-2. Pirox-CT has good oral bioavailability and a long half-life in mammals, but PD and PK studies have not been carried out in any avian species. Despite the high incidence of negative side effects of Pirox-CT used in humans, there are no reports of its toxicity in birds. It has been used clinically for the long-term treatment of chronic arthritis in cranes. 23
ВїCГіmo se debe usar este medicamento?
El Pirox-CT viene envasado en forma de cГЎpsula para tomar por vГa oral. Por lo general se toma 1 Гі 2 veces al dГa. Tome el Pirox-CT alrededor del mismo horario todos los dГas. Siga cuidadosamente las instrucciones en la etiqueta del medicamento y pregГєntele a su doctor o farmacГ©utico cualquier cosa que no entienda. Use el medicamento exactamente como se indica. No use mГЎs ni menos que la dosis indicada ni tampoco mГЎs seguido que lo prescrito por su doctor.
Trague las cГЎpsulas enteras; no las mastique ni las triture.
El Pirox-CT ayudarГЎ a controlar sus sГntomas pero no curarГЎ su condiciГіn. Puede tomar 8 a 12 semanas o mГЎs tiempo antes de que sienta el beneficio total de tomar este medicamento.
¿Cuál es la información más importante que debo saber sobre Pirox-CT?
Pirox-CT puede aumentar su riesgo de ataques al corazón o accidentes cerebrovasculares fatales, especialmente si usted la usa por largo tiempo o toma dosis elevadas, o si tiene enfermedad del corazón. No use esta medicina justo antes o después de tener una cirugía de puente (bypass) aortocoronario con injerto (CABG por sus siglas en Inglés).
Pirox-CT también puede causar sangrado del estómago o intestino, lo que podría ser fatal. Estas condiciones pueden ocurrir sin ninguna advertencia mientras esté usando Pirox-CT, especialmente en los adultos mayores.
Pirox-CT disease interactions
There are 12 disease interactions with Pirox-CT which include:
When Pirox-CT was administered with aspirin, its protein binding was reduced, although the clearance of free FELDENE was not altered. Plasma levels of Pirox-CT were decreased to approximately 80% of their normal values when FELDENE was administered (20 mg/day) in conjunction with aspirin (3900 mg/day). The clinical significance of this interaction is not known .
Storage And Handling
FELDENE ® (Pirox-CT) 10 mg capsules are maroon and blue #322, supplied as:
FELDENE ® (Pirox-CT) 20 mg capsules are maroon #323, supplied as:
How it works
It isn’t completely understood how Pirox-CT works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.
NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.
Pirox-CT oral capsule doesn’t cause drowsiness, but it can cause other side effects.