Pirocaps capsules

Pirocaps

  • Active Ingredient: Piroxicam
  • 20 mg
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What is Pirocaps?

The active ingredient of Pirocaps brand is piroxicam. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. It is slightly soluble in alcohol and in aqueous solutions. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). The inactive ingredients in Piroxicam include: Blue 1, Red 3, lactose, magnesium stearate, sodium lauryl sulfate, starch.

Used for

Pirocaps is used to treat diseases such as: Frozen Shoulder, Osteoarthritis, Pain, Rheumatoid Arthritis, Temporomandibular Joint Disorder.

Side Effect

Possible side effects of Pirocaps include: large, flat, blue, or purplish patches in the skin; shakiness in the legs, arms, hands, or feet; swelling of the ankles or hands; excess air or gas in the stomach or intestines; lightheadedness; red skin lesions, often with a purple center.

How to Buy Pirocaps capsules online?

To get Pirocaps online - simply click on the "Buy Now" button in the top and follow on to our shop. Order and payment takes a couple of minutes, and all steps are evident. We do not require a medical prescription plus also we have many procedures of payment. Considering each detail of rapid shipping and confidentiality, you can read on the relevant pages on the links from the navigation menu.

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Pediatric Use

Pirocaps has not been investigated in pediatric patients. The safety and effectiveness of Pirocaps have not been established.

Pirocaps

Pirocaps is considered the standard of care for TCC in dogs and may have specific advantages over other NSAIDs.

Inducible cyclooxygenase 2 (COX-2) enzymes are not expressed in the normal urinary bladder but are upregulated in tumors including TCC. a.

COX-2 is expressed in both primary and metastatic TCC.

COX-2 enzymes and their product, prostaglandin E2 (PGE2), a potent immunosuppressive compound, promote tumor growth by preventing apoptosis, stimulating tumor cell proliferation, and promoting angiogenesis.

PGE2 concentrations are increased in the bladder mucosa of patients with TCC growth as compared with normal bladder mucosa.

Pirocaps, a COX enzyme inhibitor, has antitumor activity and decreases the size of tumors when used in dogs with TCC. a.

The mechanism of action is not based on cytotoxicity.

COX inhibition may provide some immunomodulation by suppressing PGE2 and thereby inducing apoptosis, inhibiting angiogenesis, and decreasing tumor cell proliferation.

Decreased inflammation alone cannot account for the partial and complete remissions achieved in vivo.

Pirocaps provides good control of clinical signs and improves quality of life in some patients. Owners usually note increased activity and improvement in the attitude of their pet while the dog is receiving Pirocaps.

Clinical studies of Pirocaps in dogs with TCC indicate an overall response rate of 16%.

Pirocaps provides good control of clinical signs, improving the quality of life in many dogs with TCC.

Complete remission is achieved in 4% of treated dogs.

Partial remission is observed in 13%.

Disease remained stable in 58%.

Progressive disease was noted in 25%.

Gastrointestinal toxicity occurred in 17% of treated dogs. a.

Signs of toxicity included anorexia, melena, and vomiting.

Gastroprotectants may be used in combination with Pirocaps. (1)

H2 receptor blockers.

Proton pump inhibitors.

Misoprostol (prostaglandin E1 analogue).

Acute renal failure is a potential complication of nonsteroidal anti-inflammatory drugs (NSAIDs). Renal function should be monitored regularly while prescribing this medication for dogs with TCC.

Pirocaps is used at a dosage of 0.3 mg/kg orally once daily if tolerated. It is given every other day to limit adverse effects in some patients. a.

Only 10 mg and 20 mg capsules are available.

Compounding pharmacies can reformulate this medication into varying concentrations to accommodate smaller animals.

Median survival with Pirocaps as the sole form of treatment is approximately 6 months. About 20% of treated dogs survived for one year.

Pirocaps may have unique effects against TCC as compared with other NSAIDs. This possibility has not been studied in TCC, but it is well known that each NSAID has its own profile of effect against a variety of other tumors in experimental studies in mice.

References

  1. Heerdink ER, Leufkens HG, Herings RM, Ottervanger JP, Stricker BH, Bakker A "NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics." Arch Intern Med 158 (1998): 1108-12
  2. Agnholt J, Andreasen F "The effect of ibuprofen therapy on water and electrolyte balance." Acta Med Scand 212 (1982): 65-9
  3. "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
  4. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  5. Lewis RV, Toner JM, Jackson PR, Ramsay LE "Effects of indomethacin and sulindac on blood pressure of hypertensive patients." Br Med J 292 (1986): 934-5
  6. "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
  7. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  8. Van Den Ouweland FA, Gribnau FW, Meyboom RH "Congestive heart failure due to nonsteroidal anti-inflammatory drugs in the elderly." Age Ageing 17 (1988): 8-16
  9. "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
  10. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  11. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
  12. Heynen G "Toleration and safety of Pirocaps." Eur J Rheumatol Inflamm 8 (1987): 86-93
  13. Willkens RF "Worldwide clinical safety experience with diclofenac." Semin Arthritis Rheum 2 Suppl 1 (1985): 105-10
  14. Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300
  15. "Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
  16. "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
  17. "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
  18. "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
  19. "Product Information. Feldene (Pirocaps)." Pfizer US Pharmaceuticals, New York, NY.
  20. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  21. Gurwitz JH, Everitt DE, Monane M, et al "The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons." J Gerontol A Biol Sci Med Sci 51 (1996): m74-9
  22. "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
  23. Easton PA, Koval A "Hypertensive reaction with sulindac." Can Med Assoc J 122 (1980): 1273-4
  24. Brooks CD, Linet OI, Schellenberg D, Turner LF, Defesche CL, Teoh KW, Johnson JH, Assenzo JR "Clinical safety of flurbiprofen." J Clin Pharmacol 30 (1990): 342-51
  25. Petersson I, Nilsson G, Hansson B-G, Hedner T "Water intoxication associated with non-steroidal anti-inflammatory drug therapy." Acta Med Scand 221 (1987): 221-3
  26. Buckley MM, Brogden RN "Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential." Drugs 39 (1990): 86-109
  27. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
  28. "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
  29. "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.

Pirocaps

Pirocaps is a non-steroidal anti-inflammatory drug of the ‘oxicam’ class used to relieve the symptoms of rheumatoid and osteoarthritis. It has also been used in small animal veterinary medicine to treat certain neoplasia expressing cyclooxygenase (COX) receptors, such as bladder, colon and prostate cancers. 68 There are few reports of its use in horses, but it would seem to be potentially valuable in the management of bladder and urethral tumours. There are reports of its adjunctive value in supporting treatment of some ocular and mucocutaneous carcinoma cases at 150 mg/kg per os q 24 h × 10, then q 48 h for several months. 69

The possible side-effects are not established in horses.

¿Qué sucedería en una sobredosis?

Busque atención medica de emergencia si sospecha que ha usado demasiado de esta medicina. Los síntomas de una sobredosis de Pirocaps puede incluir náusea, vómito, dolor de estómago, heces fecales negras o con sangre, o tos con sangre.

What should I avoid while taking Pirocaps?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Pirocaps.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to Pirocaps (such as aspirin, ibuprofen, ketoprofen, or naproxen).


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