Parixam capsules


  • Active Ingredient: Piroxicam
  • 20 mg
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What is Parixam?

The active ingredient of Parixam brand is piroxicam. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. It is slightly soluble in alcohol and in aqueous solutions. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). The inactive ingredients in Piroxicam include: Blue 1, Red 3, lactose, magnesium stearate, sodium lauryl sulfate, starch.

Used for

Parixam is used to treat diseases such as: Frozen Shoulder, Osteoarthritis, Pain, Rheumatoid Arthritis, Temporomandibular Joint Disorder.

Side Effect

Possible side effects of Parixam include: trembling or shaking of the hands or feet; cold sweats; back or leg pains; blood in the urine; sores, ulcers, or white spots on the lips or tongue or inside the mouth; unpleasant breath odor; burning, dry, or itching eyes; numbness or tingling in the hands, feet, or lips.

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Case 1. Acute cholestatic hepatitis arising 30 days after starting Parixam therapy.

A 74 year old woman with chronic arthritis was treated for 30 days with Parixam and presented 2 days later with pruritus and dark urine followed by jaundice. She had no history of liver disease or exposures to viral hepatitis and did not drink alcohol. She had hypertension and had been treated with atenolol and hydrochlorothiazide chronically. She had no fever or rash, but was jaundiced and had mild hepatic tenderness. Laboratory tests showed a total bilirubin of 6.5 mg/dL and prominent elevations in both ALT and alkaline phosphatase (Table) and eosinophilia. Tests for hepatitis A and B were negative. Ultrasound of the abdomen was normal. A liver biopsy showed intrahepatic cholestasis with minimal portal inflammation suggestive of drug induced liver disease. Her symptoms and jaundice cleared over the next month, and on follow up 3 months later, all liver tests were normal.

How should this medicine be used?

Parixam comes as a capsule to take by mouth. It is usually taken once or twice a day. Take Parixam at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Parixam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not chew or crush them.

Parixam will help control your symptoms but will not cure your condition. It may take 8 to 12 weeks or longer before you feel the full benefit of Parixam.

Exacerbation of Asthma Related to Aspirin Sensitivity

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSA > . When Parixam is used in patients with preexisting asthma (without known aspirin sensitivity), monitor patients for changes in the signs and symptoms of asthma.


  • Absolute: acetylsalicylic acid (ASA)/aspirinallergy
  • Relative: bleeding disorders, duodenal/gastric/peptic ulcer, stomatitis, systemic lupus erythematosus (SLE), ulcerative colitis, upper gastrointestinal (GI) disease, late pregnancy (may cause premature closure of the ductus arteriosus)

Effects of Drug Abuse

  • No information available

  • See "What Are Side Effects Associated with Using Parixam?"

  • Long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs.
  • See "What Are Side Effects Associated with Using Parixam?"

  • May increase risk of asthma (bronchial), cardiac disease, congestive heart failure (CHF), hepatic impairment, high blood pressure (hypertension), renal impairment
  • Long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs
  • May cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine when used long term and can be fatal; administer lowest effective dose for short periods; use caution
  • NSAIDs including Parixam can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal
  • Not for administration to patients that have experienced aspirin anaphylactoid reactions
  • Anemia reported in patients receiving NSAIDs, including Parixam; may prolong bleeding time; monitor
  • NSAIDs may cause adverse eye reactions; consult ophthalmologist if symptoms occur
  • Based on mechanism of action, use of prostaglandin-mediated NSAIDs, including Parixam, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women; women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of NSAIDs, including Parixam, should be considered
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) have the potential to trigger HF by prostaglandin inhibition that leads to sodium and water retention, increased systemicvascularresistance, and blunted response to diuretics
  • NSAIDs should be avoided or withdrawn whenever possible

  • Use Parixam with caution during the first and second trimesters of pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done. During the third trimester of pregnancy, use in Parixam only LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk (may cause premature closure of the ductus arteriosus).

Parixam disease interactions

There are 12 disease interactions with Parixam which include:

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