Palpasin capsules

Palpasin

  • Active Ingredient: Piroxicam
  • 20 mg
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What is Palpasin?

The active ingredient of Palpasin brand is piroxicam. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. It is slightly soluble in alcohol and in aqueous solutions. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). The inactive ingredients in Piroxicam include: Blue 1, Red 3, lactose, magnesium stearate, sodium lauryl sulfate, starch.

Used for

Palpasin is used to treat diseases such as: Frozen Shoulder, Osteoarthritis, Pain, Rheumatoid Arthritis, Temporomandibular Joint Disorder.

Side Effect

Possible side effects of Palpasin include: weight changes; red skin lesions, often with a purple center; trembling or shaking of the hands or feet; depression; Bloating; redness or other discoloration of the skin.

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¿Cómo debo tomar Palpasin?

Siga todas las instrucciones en la etiqueta de su prescripción. Tal vez su médico en ocasiones cambie su dosis para asegurarse de que está obteniendo los mejores resultados. No tome esta medicina en cantidades mayores, o por más tiempo de lo recomendado. Use la dosis más baja que es efectiva en el tratamiento de su condición.

Puede tomar hasta 2 semanas antes de que sus síntomas mejoren. Siga usando la medicina como indicado y dígale a su médico si sus síntomas no mejoran.

Si usted usa esta medicina a largo plazo, usted puede necesitar pruebas médicas frecuentes.

Guarde a temperatura ambiente fuera de la humedad y del calor.

Lea toda la información para el paciente, las guías del medicamento y las hojas de instrucción que le proporcionaron. Hable con su médico o farmacéutico si tiene alguna pregunta.

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In patients taking Palpasin or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1% to 10% of patients are:

Cardiovascular System: Edema

Digestive System: Anorexia, abdominal pain, constipation, diarrhea, flatulence, nausea, vomiting

Nervous System: Dizziness, headache, vertigo

Skin and Appendages: Pruritus, rash

Special Senses: Tinnitus

Additional adverse experiences reported occasionally include:

Cardiovascular System: Palpitations

Digestive System: Stomatitis Nervous System: Drowsiness Special Senses: Blurred vision

Palpasin has not been investigated in pediatric patients.

Pharmacokinetic differences due to race have not been identified.

What should I avoid while taking Palpasin?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Palpasin.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to Palpasin (such as aspirin, ibuprofen, ketoprofen, or naproxen).

What is Palpasin?

Palpasin is a nonsteroidal anti-inflammatory drug (NSAID).

Palpasin is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis.

Palpasin may also be used for purposes not listed in this medication guide.

DiureticsClinical Impact:Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis.Intervention:During concomitant use of FELDENE with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects .DigoxinClinical Impact:The concomitant use of Palpasin with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.Intervention:During concomitant use of FELDENE and digoxin, monitor serum digoxin levels.LithiumClinical Impact:NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis.Intervention:During concomitant use of FELDENE and lithium, monitor patients for signs of lithium toxicity.MethotrexateClinical Impact:Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction).Intervention:During concomitant use of FELDENE and methotrexate, monitor patients for methotrexate toxicity.CyclosporineClinical Impact:Concomitant use of FELDENE and cyclosporine may increase cyclosporine's nephrotoxicity.Intervention:During concomitant use of FELDENE and cyclosporine, monitor patients for signs of worsening renal function.NSAIDs and SalicylatesClinical Impact:Concomitant use of Palpasin with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy .Intervention:The concomitant use of Palpasin with other NSAIDs or salicylates is not recommended.PemetrexedClinical Impact:Concomitant use of FELDENE and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (see the pemetrexed prescribing information).Intervention:During concomitant use of FELDENE and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.Highly Protein Bound DrugsClinical Impact:FELDENE is highly protein bound and, therefore, might be expected to displace other protein bound drugs.Intervention:Physicians should closely monitor patients for a change in dosage requirements when administering FELDENE to patients on other highly protein bound drugs.CorticosteroidsClinical Impact:Concomitant use of corticosteroids with FELDENE may increase the risk of GI ulceration or bleeding.Intervention:Monitor patients with concomitant use of FELDENE with corticosteroids for signs of bleeding .

Cardiovascular Thrombotic Events

  • Nonstero > .
  • Palpasin is contraindicated in the setting of coronary artery bypass graft (CABG) surgery .

Gastrointestinal Bleeding, Ulceration, and Perforation

NSA > .

Heart Failure And Edema

The Coxib and traditional NSAID Trialists’ Collaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. In a Danish National Registry study of patients with heart failure, NSAID use increased the risk of MI, hospitalization for heart failure, and death.

Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of Palpasin may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers ) .

Avoid the use of FELDENE in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure. If FELDENE is used in patients with severe heart failure, monitor patients for signs of worsening heart failure.

Gastrointestinal Bleeding, Ulceration, and Perforation

NSAIDs, including Palpasin, cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3 months to 6 months, and in about 2% to 4% of patients treated for one year. However, even short-term NSAID therapy is not without risk.

Risk Factors for GI Bleeding, Ulceration, and Perforation

Patients with a prior history of peptic ulcer disease and/or GI bleeding who used NSAIDs had a greater than 10-fold increased risk for developing a GI bleed compared to patients without these risk factors. Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. Most postmarketing reports of fatal GI events occurred in elderly or debilitated patients. Additionally, patients with advanced liver disease and/or coagulopathy are at increased risk for GI bleeding.

Strategies to Minimize the GI Risks in NSAID-treated patients:

  • Use the lowest effective dosage for the shortest possible duration.
  • Avo > .

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term animal studies have not been conducted to characterize the carcinogenic potential of Palpasin.

Palpasin was not mutagenic in an Ames bacterial reverse mutation assay, or in a dominant lethal mutation assay in mice, and was not clastogenic in an in vivo chromosome aberration assay in mice.

Impairment of Fertility

Reproductive studies in which rats were administered Palpasin at doses of 2 mg/kg/day, 5 mg/kg/day, or 10 mg/kg/day (up to 5 times the maximum recommended human dose of 20 mg based on mg/m2 body surface area ) revealed no impairment of male or female fertility.

Warnings

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase risk of serious cardiovascular thrombotic events, heart attack (myocardial infarction ), and stroke, which can be fatal
  • Risk may increase with duration of use
  • Patients with risk factors for or existing cardiovascular disease may be at greater risk
  • NSAIDs are contraindicated for perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (increased risk of MI and stroke)

  • NSAIDs increase risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
  • GI adverse events may occur at any time during use and without warning symptoms
  • Elderly patients are at greater risk for serious GI events

This medication contains Palpasin. Do not take Feldene if you are allergic to Palpasin or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


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