NeoProfen tablets

NeoProfen

  • Active Ingredient: Ibuprofen
  • 600 mg, 400 mg
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What is NeoProfen?

The active ingredient of NeoProfen brand is ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Used for

NeoProfen is used to treat diseases such as: Aseptic Necrosis, Back Pain, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Patent Ductus Arteriosus, Period Pain, Plantar Fasciitis, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Temporomandibular Joint Disorder, Toothache, Transverse Myelitis.

Side Effect

Possible side effects of NeoProfen include: stiff neck or back; Bluish lips or skin; difficulty breathing; paranoia; hair loss, thinning of hair; muscle tremors.

How to Buy NeoProfen tablets online?

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What brand names are available for NeoProfen?

  • Advil
  • Pediatric Advil
  • Advil/Motrin
  • Advil Migraine
  • Medipren
  • Motrin
  • Nuprin
  • PediaCareChildren’s Pain Reliever/Fever Reducer
  • PediaCare Infant’s Pain Reliever/Fever Reducer Fever
  • Caldolor
  • Duexis
  • IBU-Tab
  • Neoprofen (NeoProfen lysine)
  • Many others

Before taking NeoProfen,

  • tell your doctor and pharmacist if you are allergic to NeoProfen, aspirin or other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the type of NeoProfen you plan to take. Ask your pharmacist or check the label on the package for a list of the inactive ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • do not take nonprescription NeoProfen with any other medication for pain unless your doctor tells you that you should.
  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving NeoProfen to a child, tell the child's doctor if the child has not been drinking fluids or has lost a large amount of fluid from repeated vomiting or diarrhea.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy; you plan to become pregnant; or you are breast-feeding. If you become pregnant while taking NeoProfen, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking NeoProfen.
  • if you have phenylketonuria (PKU, an inborn disease in which mental retardation develops if a specific diet is not followed), read the package label carefully before taking nonprescription NeoProfen. Some types of nonprescription NeoProfen may be sweetened with aspartame, a source of phenylalanine.

Duration of Effectiveness

In a double-blind study, it was found that 12 hours after the dose was administered naproxen sodium (Aleve) was significantly more effective in relieving pain than NeoProfen (Advil).

Is NeoProfen safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of NeoProfen in pregnant women. Therefore, NeoProfen is not recommended during pregnancy. NeoProfen should be avoided in late pregnancy due to the risk of premature closure of the ductus arteriosus in the fetal heart.

NeoProfen is excreted in breast milk but the American Academy of Pediatrics states that NeoProfen is compatible with breastfeeding.

PATIENT INFORMATION

Allergy alert: NeoProfen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:

If an allergic reaction occurs, stop use and seek medical help right away.

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:

  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • are age 60 or older
  • take other drugs containing prescription or nonprescription NSAIDs
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed

  • if you have ever had an allergic reaction to any other pain reliever/fever reducer
  • right before or after heart surgery

Ask a doctor before use if

  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic
  • you have problems or serious side effects from taking pain relievers or fever reducers
  • you have asthma

Ask a doctor or pharmacist before use if you are

  • under a doctor's care for any serious condition
  • taking aspirin for heart attack or stroke, because NeoProfen may decrease this benefit of aspirin
  • taking any other drug

When using this product

  • take with food or milk if stomach upset occurs
  • the risk of heart attack or stroke may increase if you use more than directed or for longer than directed

Stop use and ask a doctor if

  • you experience any of the following signs of stomach bleeding:
    • feel faint
    • have bloody or black stools
    • vomit blood
    • have stomach pain that does not get better
  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present in the painful area
  • any new symptoms appear

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use NeoProfen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Breastfeeding

A dosage of 400 mg of NeoProfen is not detectable in breast milk, but higher doses can get into breast milk. This means that a baby faces exposure to NeoProfen through breast milk if a woman takes too much.

Healthcare professionals do not know the effects of small amounts of NeoProfen in breast milk on infants. A person should consult a physician before taking NeoProfen while breastfeeding.

The majority of NeoProfen overdoses are not life-threatening, and fewer than 1% of NeoProfen overdoses are fatal. That said, some people have had severe complications.

There is no specific cutoff dosage for when an adult will experience symptoms of an overdose.

If a child ingests less than 100 mg/kg of NeoProfen, they may not experience any symptoms of an overdose. At a dosage of 400 mg/kg, however, a child may experience serious and life-threatening side effects.

Symptoms of NeoProfen overdose can occur within 4 hours of taking too much of the drug.

Dosage 200-800 mg per dose 220 mg (OTC dosage) Forms Advil is available in the form of tablets, chewable tablets, capsules, gelcaps, suspensions and oral drops. Aleve is available in tablets, caplets, liquid gels and gelcaps. Active ingredient NeoProfen Naproxen Side effects Nausea, dizziness, gastrointestinal bleeding Higher incidence of photosensitivity and digestive tract problems. Brand owned by Pfizer (formerly Wyeth) Bayer Mechanism of action Acts by inhibiting cyclooxygenases (COX-1 and COX-2) Acts by inhibiting cyclooxygenases (COX-1 and COX-2) FDA approval 1974 1991 Benefits Relief from body ache (including arthritis), fever reduction, anti clotting Relief from body ache (including arthritis), fever reduction, anti clotting. Available over the counter Yes Yes

What should I avoid while taking NeoProfen?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking NeoProfen.

Avoid taking NeoProfen if you are taking aspirin to prevent stroke or heart attack. NeoProfen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the NeoProfen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form).

Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain aspirin or other medicines similar to NeoProfen. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, NeoProfen, ketoprofen, or naproxen.

What are the uses for NeoProfen?

NeoProfen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases. It is used for treating menstrual cramps (dysmenorrhea), osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis. Intravenous NeoProfen is used for treating patent ductus arteriosus.

2. Key facts

  • NeoProfen takes 20 to 30 minutes to work if you take it by mouth. It takes 1 to 2 days to work if you put it on your skin.
  • NeoProfen works by reducing hormones that cause pain and swelling in the body.
  • For strains and sprains, some doctors and pharmacists recommend waiting 48 hours before taking NeoProfen as it may slow down healing. If you're unsure speak to a pharmacist.
  • NeoProfen is typically used for period pain or toothache. Some people find NeoProfen better than paracetamol for back pain.
  • Always take NeoProfen tablets and capsules with food or a drink of milk to reduce the chance of an upset stomach. Do not take it on an empty stomach.
  • If you're taking tablets, take the lowest dose for the shortest time. Do not use it for more than 10 days unless you've spoken to your doctor. Do not use the gel, mousse or spray for more than 2 weeks without talking to your doctor.
  • NeoProfen is called by different brand names, including Nurofen, Brufen and Calprofen (syrup). NeoProfen gel can be called Fenbid, Ibugel and Ibuleve.

What is NeoProfen? How does it work (mechanism of action)?

NeoProfen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include aspirin, naproxen (Aleve), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. NeoProfen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved NeoProfen in 1974.

Dosage for Motrin (NeoProfen)

The recommended dose of Motrin should be adjusted to suit individual patients needs but should not exceed 3200 mg in the total daily dose.

What other drugs will affect NeoProfen?

Ask your doctor before using NeoProfen if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use NeoProfen if you are also using any of the following drugs:

a blood thinner (warfarin, Coumadin, Jantoven);

heart or blood pressure medication, including a diuretic or "water pill" as well as “ACE-inhibitor” medications; or

This list is not complete. Other drugs may interact with NeoProfen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Which drugs or supplements interact with NeoProfen?

NeoProfen is associated with several suspected or probable interactions that can affect the action of other drugs.

  • NeoProfen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
  • NeoProfen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
  • When NeoProfen is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
  • NeoProfen increases the negative effect of cyclosporine on kidney function.
  • Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid NeoProfen because NeoProfen also thins the blood, and excessive blood thinning may lead to bleeding.
  • If aspirin is taken with NeoProfen there may be an increased risk for developing an ulcer.
  • Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking NeoProfen or other NSAIDs.
  • Combining SSRIs or selective serotonin reuptake inhibitors (for example, fluoxetine , citalopram , paroxetine [Paxil, Paxil CR, Pexeva) with NSAIDs may increase the likelihood of upper gastrointestinal bleeding.


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