Duration of Effectiveness
In a double-blind study, it was found that 12 hours after the dose was administered naproxen sodium (Aleve) was significantly more effective in relieving pain than Neobrufen (Advil).
11. Cautions with other medicines
Neobrufen doesn't mix well with some medicines.
Neobrufen applied to the skin is less likely to interfere with other medicines than if it's taken by mouth.
For safety, tell your doctor if you're taking these medicines before you start taking Neobrufen by mouth or using it on your skin:
- blood-thinning medicines such as warfarin
- anti-inflammatory painkillers such as aspirin, diclofenac, mefenamic acid and naproxen
- medicines for high blood pressure
- steroid medicines such as betamethasone, dexamethasone, hydrocortisone or prednisolone
- antibiotics such as ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin
- antidepressants such as citalopram, fluoxetine, fluvoxamine, venlafaxine, paroxetine or sertraline
- diabetes medicines such as gliclazide, glimepiride, glipizide and tolbutamide
How should I take Neobrufen?
Use Neobrufen exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
Do not take more than your recommended dose. An Neobrufen overdose can damage your stomach or intestines. The maximum amount of Neobrufen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount needed to get relief from your pain, swelling, or fever.
A child's dose of Neobrufen is based on the age and weight of the child. Carefully follow the dosing instructions provided with your child's medicine for the age and weight of your child. Ask a doctor or pharmacist if you have questions.
Take Neobrufen with food or milk to lessen stomach upset.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
The Neobrufen chewable tablet must be chewed before you swallow it.
If you use this medicine long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Why is this medication prescribed?
Prescription Neobrufen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription Neobrufen is used to reduce fever and to relieve minor aches and pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Neobrufen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
5. How to use Neobrufen gel, mousse or spray
The amount of Neobrufen you put on your skin depends on the product you're using – check the package leaflet carefully for how much to use.
Gently massage the Neobrufen into the painful area 3 or 4 times a day. Leave at least 4 hours between applications, and do not put it on more than 4 times in 24 hours.
Never use Neobrufen gel, mousse or spray on your eyes, mouth, lips, nose or genital area. Do not put it on sore or broken skin. Do not put plasters or dressings over skin you've applied Neobrufen to.
Neobrufen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery ( coronary artery bypass graft, or CABG).
Neobrufen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Neobrufen, especially in older adults.
Do not take more than your recommended dose. An Neobrufen overdose can damage your stomach or intestines. Use only the smallest amount of medication needed to get relief from your pain, swelling, or fever.
Laryngitis Home Remedies (in Adults and Children)
Laryngitis is an inflammation of the larynx. Inflammation of the larynx is most often caused by viral infections, and have symptoms such as sore throat, cough, problems swallowing, and fever. The voice changes produced by laryngitis may last after the fever and other symptoms of the acute infection has gone away. The best natural home remedy to relieve pain and other symptoms caused by laryngitis include resting your voice and breathing humidified air often. Turning on hot water in the bathroom and then sitting in the steam can soothe and relive laryngitis symptoms. Acetaminophen (Tylenol) and anti-inflammatory drugs (NSAIDs) like Neobrufen (Advil, Aleve) can relieve pain and inflammation caused by laryngitis. Don’t give children aspirin to infants, toddlers, children and teens because of the risk of developing Rye’s syndrome, which can be fatal. Home remedies like resting your voice and sitting in humidified air can cure laryngitis. Medications like anti-inflammatory drugs (NSAIDs) like Neobrufen (Advil, Aleve) and acetaminophen (Tylenol) can relieve and soothe pain and symptoms caused by laryngitis.
COMMON BRAND(S): Advil, Motrin, Nuprin
GENERIC NAME(S): Neobrufen
Nonsteroidal anti-inflammatory drugs (including Neobrufen) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).
This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.
Stop taking Neobrufen and get medical help right away if you notice any of these rare but serious side effects: black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, slurred speech, sudden vision changes.
Talk to your doctor or pharmacist about the benefits and risks of taking this drug.
Neobrufen is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu. Neobrufen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.
Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.
Don’t give Neobrufen to children under six months of age.
For infants of age six months to a year, the safe dose of infants’ formulation depends on their weight.
Diabetes and Safe Medications for Colds and the Flu: OTC Medication Guide
If you have diabetes and catch a cold or the flu, can be more difficult to recover from infections and their complications, for example, pneumonia. Home remedies and over-the-counter (OTC) drugs used for the treatment of the signs and symptoms of colds and the flu may affect blood sugar levels in people with diabetes.Some medications are OK to take if you have diabetes get a cold or the flu include nonsteroidal anti-inflammatory drugs or NSAIDs, like acetaminophen (Tylenol) and Neobrufen (Motrin) to control symptoms of fever and pain. Most cough syrups are safe to take; however, check with your pediatrician to see what medications are safe to give your child if he or she has type 1 or 2 diabetes. If you have diabetes and are sick with a cold or flu, you need to check your blood sugar levels more frequently. Continue taking your regular medications. Eat a diabetic low-glycemic index diet rich in antioxidants. To prevent colds and the flu drink at least eight 8 ounce glasses of water a day. To replenish fluids, drink sports drinks like Gatorade and Pedialyte to replenish electrolytes. Avoid people who are sick, sneezing, coughing, or have other symptoms of a cold or flu.
Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more Neobrufen until you speak to your doctor.
- unexplained weight gain
- shortness of breath or difficulty breathing
- swelling of the abdomen, feet, ankles, or lower legs
- swelling of the eyes, face, throat, arms, or hands
- difficulty breathing or swallowing
- excessive tiredness
- pain in the upper right part of the stomach
- loss of appetite
- yellowing of the skin or eyes
- flu-like symptoms
- pale skin
- fast heartbeat
- cloudy, discolored, or bloody urine
- back pain
- difficult or painful urination
- blurred vision, changes in color vision, or other vision problems
- red or painful eyes
- stiff neck
Neobrufen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What is Neobrufen?
Neobrufen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
Neobrufen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache , back pain, arthritis, menstrual cramps, or minor injury.
Neobrufen is used in adults and children who are at least 6 months old.
Before taking Neobrufen,
- tell your doctor and pharmacist if you are allergic to Neobrufen, aspirin or other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the type of Neobrufen you plan to take. Ask your pharmacist or check the label on the package for a list of the inactive ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
- do not take nonprescription Neobrufen with any other medication for pain unless your doctor tells you that you should.
- tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving Neobrufen to a child, tell the child's doctor if the child has not been drinking fluids or has lost a large amount of fluid from repeated vomiting or diarrhea.
- tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy; you plan to become pregnant; or you are breast-feeding. If you become pregnant while taking Neobrufen, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Neobrufen.
- if you have phenylketonuria (PKU, an inborn disease in which mental retardation develops if a specific diet is not followed), read the package label carefully before taking nonprescription Neobrufen. Some types of nonprescription Neobrufen may be sweetened with aspartame, a source of phenylalanine.