Micar capsules

Micar

  • Active Ingredient: Piroxicam
  • 20 mg
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What is Micar?

The active ingredient of Micar brand is piroxicam. Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid, and most organic solvents. It is slightly soluble in alcohol and in aqueous solutions. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). The inactive ingredients in Piroxicam include: Blue 1, Red 3, lactose, magnesium stearate, sodium lauryl sulfate, starch.

Used for

Micar is used to treat diseases such as: Frozen Shoulder, Osteoarthritis, Pain, Rheumatoid Arthritis, Temporomandibular Joint Disorder.

Side Effect

Possible side effects of Micar include: stiff neck or back; hair loss or thinning of the hair; swelling of the face, fingers, feet, or lower legs; pains in the stomach, side, or abdomen, possibly radiating to the back; slow, fast, pounding, or irregular heartbeat or pulse; shakiness.

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Indications and Usage for Micar

Micar capsules, USP are indicated:

  • For relief of the signs and symptoms of osteoarthritis.
  • For relief of the signs and symptoms of rheumato > Carefully cons > .

After observing the response to initial therapy with Micar, the dose and frequency should be adjusted to suit an individual patient's needs.

For the relief of rheumatoid arthritis and osteoarthritis, the dosage is 20 mg given orally once per day. If desired, the daily dose may be divided. Because of the long half-life of Micar, steady-state blood levels are not reached for 7 days to 12 days. Therefore, although the therapeutic effects of Micar are evident early in treatment, there is a progressive increase in response over several weeks and the effect of therapy should not be assessed for two weeks.

Mechanism Of Action

Micar has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of FELDENE, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Micar is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Micar concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Micar is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Micar disease interactions

There are 12 disease interactions with Micar which include:

How it works

It isn’t completely understood how Micar works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

Micar oral capsule doesn’t cause drowsiness, but it can cause other side effects.

Metabolism of Micar occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. In vitro studies indicate cytochrome P4502C9 (CYP2C9) as the main enzyme involved in the formation to the 5’-hydroxy-Micar, the major metabolite . The biotransformation products of Micar metabolism are reported to not have any anti-inflammatory activity.

Higher systemic exposure of Micar has been noted in subjects with CYP2C9 polymorphisms compared to normal metabolizer type subjects .

Micar and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a FELDENE dose is excreted unchanged. The plasma half-life (t½ ) for Micar is approximately 50 hours.

Micar ↔ Alcohol (Ethanol)

Moderate Drug Interaction

Ask your doctor before using Micar together with ethanol. Do not drink alcohol while taking Micar. Alcohol can increase your risk of stomach bleeding caused by Micar. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.


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