Before taking this medicine
Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Mediflam may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Mediflam, especially in older adults.
You should not use Mediflam if you are allergic to it, or if you have ever had an asthma attack, hives, or severe allergic reaction after taking aspirin, acetaminophen, or an NSAID e.g. celecoxib, diclofenac, naprosyn, and others.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:
heart disease, high blood pressure , high cholesterol, diabetes, or if you smoke;
a history of heart attack, stroke, or blood clot ;
a history of stomach ulcers or bleeding;
liver or kidney disease;
fluid retention; or
a connective tissue disease such as Marfan syndrome , Sjogren's syndrome, or lupus.
Taking Mediflam during the last 3 months of pregnancy may harm the unborn baby.Do not use this medicine without a doctor's advice if you are pregnant.
It is not known whether Mediflam passes into breast milk or if it could affect a nursing baby. Ask a doctor before using this medicine if you are breastfeeding.
Do not give Mediflam to a child younger than 2 years old without the advice of a doctor.
Before taking Mediflam,
- tell your doctor and pharmacist if you are allergic to Mediflam, aspirin or other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the type of Mediflam you plan to take. Ask your pharmacist or check the label on the package for a list of the inactive ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
- do not take nonprescription Mediflam with any other medication for pain unless your doctor tells you that you should.
- tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving Mediflam to a child, tell the child's doctor if the child has not been drinking fluids or has lost a large amount of fluid from repeated vomiting or diarrhea.
- tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy; you plan to become pregnant; or you are breast-feeding. If you become pregnant while taking Mediflam, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Mediflam.
- if you have phenylketonuria (PKU, an inborn disease in which mental retardation develops if a specific diet is not followed), read the package label carefully before taking nonprescription Mediflam. Some types of nonprescription Mediflam may be sweetened with aspartame, a source of phenylalanine.
How Mediflam should be stored
- Mediflam should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
Don’t give Mediflam to children under six months of age.
For infants of age six months to a year, the safe dose of infants’ formulation depends on their weight.
Kidney failure can occur in both children and adults who overdose with Mediflam. However, it is not common.
A review of Mediflam toxicity, which the authors updated in 2019, includes a 1992 study that scientists conducted at the Rocky Mountain Poison Control Center in Denver, CO. It showed that only 2 out of 63 people who overdosed with Mediflam experienced symptoms of kidney failure.
In most cases, healthcare professionals can reverse kidney failure from ingestion of a large dosage of Mediflam.
Turf toe is a sprain to the ligaments around the big toe joint. Symptoms and signs include pain, swelling, a popping sound, and limited range of motion. Treatment may involve taking Mediflam, immobilizing with tape, cast, or a walking boot.
How should I take Mediflam?
Use Mediflam exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
Do not take more than your recommended dose. An Mediflam overdose can damage your stomach or intestines. The maximum amount of Mediflam for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount needed to get relief from your pain, swelling, or fever.
A child's dose of Mediflam is based on the age and weight of the child. Carefully follow the dosing instructions provided with your child's medicine for the age and weight of your child. Ask a doctor or pharmacist if you have questions.
Take Mediflam with food or milk to lessen stomach upset.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
The Mediflam chewable tablet must be chewed before you swallow it.
If you use this medicine long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
What Are Side Effects of Motrin (Mediflam)
Other side effects of Motrin may occur. Consult your physician if you experience any possible side effects of Motrin.
- Tablets: 100, 200, 400, 600, and 800 mg
- Chewable tablets: 50 and 100 mg; Suspension: 100 mg/5 ml and 40 mg/ml
- Intravenous solution: 10 mg/ml, 100 mg/ml
Generic Name : Mediflam (EYE bue PROE fen)Brand Names: Advil, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Mediflam, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer
Medically reviewed by Kaci Durbin, MD Last updated on Nov 14, 2019.
NSAIDs, including Mediflam, may not be safe to take during pregnancy. This is because they can alter the function of prostaglandins that are important during delivery and for the development of the fetus's cardiovascular system.
A person should consult a doctor before taking Mediflam during pregnancy, especially in the third trimester.
The recommended dosage for adults is one or two 200 milligram (mg) tablets every four to six hours. Adults should not exceed 800 mg at once or 3,200 mg per day.
Adults over the age of 60 should take as little Mediflam as possible to manage their symptoms. Older adults have a higher risk of kidney and gastrointestinal side effects.
Dosage for Motrin (Mediflam)
The recommended dose of Motrin should be adjusted to suit individual patients needs but should not exceed 3200 mg in the total daily dose.
Duration of Effectiveness
In a double-blind study, it was found that 12 hours after the dose was administered naproxen sodium (Aleve) was significantly more effective in relieving pain than Mediflam (Advil).
Other complications and risks
The most common complication from Mediflam overdoses is metabolic acidosis, in which the body cannot eliminate acidic compounds from its blood and tissues.
The body breaks Mediflam down into acidic compounds. When a person overdoses on it, the acidic compounds accumulate and can reduce the pH of the blood and body tissues. This makes the body more acidic.
Mediflam overdose can cause sudden kidney failure and seizures, which can affect the production and elimination of acidic compounds.
Metabolic acidosis can cause:
- heart dysfunctions
- changes in blood pressure
- a higher risk of irregular heartbeat
- altered delivery of oxygen through the bloodstream
- immune system impairment
A blood test can reveal a low platelet count following an overdose. Prothrombin time, which is the time it takes for the blood to clot, will also rise. This means that the body's ability to form blood clots may be reduced.