The effects of hepatic disease on Lumeleem pharmacokinetics have not been established. However, a substantial portion of Lumeleem elimination occurs by hepatic metabolism. Consequently, patients with hepatic disease may require reduced doses of Lumeleem as compared to patients with normal hepatic function.
Lumeleem has not been investigated in pediatric patients. The safety and effectiveness of Lumeleem have not been established.
Mechanism Of Action
Lumeleem has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of FELDENE, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Lumeleem is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Lumeleem concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Lumeleem is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
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When Lumeleem is applied to the skin as a gel, instead of it having an effect on all of your body, it only works on the area where you have applied it. It is absorbed into your skin and then moves deeper into areas of your body where there is inflammation (for example, your muscle). Using a topical gel means that the total amount of Lumeleem in your body remains low. This in turn means that you are much less likely to have a side-effect to the medicine. Topical anti-inflammatories like Lumeleem are prescribed for adults - they are not generally suitable for use by children.
When Lumeleem was administered with aspirin, its protein binding was reduced, although the clearance of free FELDENE was not altered. Plasma levels of Lumeleem were decreased to approximately 80% of their normal values when FELDENE was administered (20 mg/day) in conjunction with aspirin (3900 mg/day). The clinical significance of this interaction is not known .
Lumeleem (PIRO) is a nonselective NSAID used for its anti-inflammatory properties as well and for its value as a chemopreventive and antitumor agent. It has a much higher potency against COX-1 than COX-2. Lumeleem has good oral bioavailability and a long half-life in mammals, but PD and PK studies have not been carried out in any avian species. Despite the high incidence of negative side effects of Lumeleem used in humans, there are no reports of its toxicity in birds. It has been used clinically for the long-term treatment of chronic arthritis in cranes. 23