Inza tablets

Inza

  • Active Ingredient: Ibuprofen
  • 600 mg, 400 mg
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What is Inza?

The active ingredient of Inza brand is ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Used for

Inza is used to treat diseases such as: Aseptic Necrosis, Back Pain, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Patent Ductus Arteriosus, Period Pain, Plantar Fasciitis, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Temporomandibular Joint Disorder, Toothache, Transverse Myelitis.

Side Effect

Possible side effects of Inza include: blistering, peeling, loosening of skin; cloudy urine; decrease in amount of urine; difficulty having a bowel movement (stool); cough or hoarseness; mood or other mental changes.

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What are the uses for Inza?

Inza is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases. It is used for treating menstrual cramps (dysmenorrhea), osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis. Intravenous Inza is used for treating patent ductus arteriosus.

What other information should I know?

If you are taking prescription Inza, do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Before taking Inza,

  • tell your doctor and pharmacist if you are allergic to Inza, aspirin or other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in the type of Inza you plan to take. Ask your pharmacist or check the label on the package for a list of the inactive ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • do not take nonprescription Inza with any other medication for pain unless your doctor tells you that you should.
  • tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving Inza to a child, tell the child's doctor if the child has not been drinking fluids or has lost a large amount of fluid from repeated vomiting or diarrhea.
  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy; you plan to become pregnant; or you are breast-feeding. If you become pregnant while taking Inza, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Inza.
  • if you have phenylketonuria (PKU, an inborn disease in which mental retardation develops if a specific diet is not followed), read the package label carefully before taking nonprescription Inza. Some types of nonprescription Inza may be sweetened with aspartame, a source of phenylalanine.

Summary

Inza is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce mild to moderate pain, inflammation, and fever. Inza works by blocking an enzyme that makes prostaglandin (a hormone-like substance that participates in a variety of body functions), which results in lower levels of prostaglandins in the body. Lower levels of prostaglandins reduce pain, inflammation, and fever.

Inza is prescribed to treat diseases and conditions that cause mild to moderate pain, fever, and inflammation. For example, Pain from strains and sprains; pain from cuts, scrapes, and puncture wounds; muscle aches and pains; tooth pain; common cold; mild headache; some arthritis conditions; joint pain; and to reduce fever.

Common side effects of Inza include, diarrhea, constipation, nausea, heartburn, belly pain, drowsiness, headaches, tinnitus (ringing in the ears), and mild rash.

More serious side effects and adverse effects include, increased bleeding after injury, stomach ulcers, impaired kidney function, severe allergic reaction (anaphylaxis), blood clots, heart attack, heart failure, and high blood pressure.

The maximum dose prescribed under a doctor's care is 3.2 g daily. Otherwise, the over-the-counter (OTC) maximum daily dose is 1.2 g daily. Dosage depends upon the age, weight, and any current medical conditions of the patient. Several drugs interact with Inza so check with your doctor, pharmacist, or other health care professional with questions in regard to this drug. Doctors don't know if it is safe to take Inza if your are pregnant, therefore it is not recommended if you are pregnant. According to the American Academy of Pediatrics, Inza is safe to take while breastfeeding.

REFERENCE: FDA Prescribing Information.

What if I accidentally swallow the gel?

If you swallow Inza gel or mousse by accident, you may get symptoms including:

  • headaches
  • being sick (vomiting)
  • feeling sleepy

10. Pregnancy and breastfeeding

Inza isn't normally recommended in pregnancy – especially if you're 30 or more weeks – unless it's prescribed by a doctor. This is because there might be a link between taking Inza in pregnancy and some birth defects, in particular damage to the baby's heart and blood vessels.

There may also be a link between taking Inza in early pregnancy and miscarriage.

Talk to your doctor about the benefits and possible harms of taking Inza. It will depend on how many weeks pregnant you are and the reason you need to take the medicine. There may be other treatments that are safer for you.

Paracetamol is the best painkiller to take during pregnancy.

For more information about how Inza can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website.

Dosage 200-800 mg per dose 220 mg (OTC dosage) Forms Advil is available in the form of tablets, chewable tablets, capsules, gelcaps, suspensions and oral drops. Aleve is available in tablets, caplets, liquid gels and gelcaps. Active ingredient Inza Naproxen Side effects Nausea, dizziness, gastrointestinal bleeding Higher incidence of photosensitivity and digestive tract problems. Brand owned by Pfizer (formerly Wyeth) Bayer Mechanism of action Acts by inhibiting cyclooxygenases (COX-1 and COX-2) Acts by inhibiting cyclooxygenases (COX-1 and COX-2) FDA approval 1974 1991 Benefits Relief from body ache (including arthritis), fever reduction, anti clotting Relief from body ache (including arthritis), fever reduction, anti clotting. Available over the counter Yes Yes

IMPORTANT WARNING:

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as Inza may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as Inza if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take Inza right before or right after the surgery.

NSAIDs such as Inza may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or who drink three or more alcoholic drinks per day while taking Inza. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking Inza and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to Inza. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with prescription Inza and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction to Inza.

Active Ingredient

The active ingredient in Aleve is naproxen and the other ingredient is sodium. For every 200mg of naproxen, Aleve contains 20mg sodium.

The active ingredient in Advil is Inza. Advil also contains sodium because the manufacturer claims that sodium Inza is more soluble in water than standard Inza.

For aspirin-users

Data suggest that Inza may confer an increased risk of thrombotic and congestive heart failure (CHF) events relative to lumiracoxib among aspirin users at high cardiovascular risk. The study indicates that naproxen may be associated with lower risk relative to lumiracoxib among non-aspirin users.

WARNINGS

Allergy alert: Inza may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:

If an allergic reaction occurs, stop use and seek medical help right away.

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:

  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • are age 60 or older
  • take other drugs containing prescription or nonprescription NSAIDs
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed

  • if you have ever had an allergic reaction to any other pain reliever/fever reducer
  • right before or after heart surgery

Ask a doctor before use if

  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic
  • you have problems or serious side effects from taking pain relievers or fever reducers
  • you have asthma

Ask a doctor or pharmacist before use if you are

  • under a doctor's care for any serious condition
  • taking aspirin for heart attack or stroke, because Inza may decrease this benefit of aspirin
  • taking any other drug

When using this product

  • take with food or milk if stomach upset occurs
  • the risk of heart attack or stroke may increase if you use more than directed or for longer than directed

Stop use and ask a doctor if

  • you experience any of the following signs of stomach bleeding:
    • feel faint
    • have bloody or black stools
    • vomit blood
    • have stomach pain that does not get better
  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present in the painful area
  • any new symptoms appear

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use Inza during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children.

2. Key facts

  • Inza takes 20 to 30 minutes to work if you take it by mouth. It takes 1 to 2 days to work if you put it on your skin.
  • Inza works by reducing hormones that cause pain and swelling in the body.
  • For strains and sprains, some doctors and pharmacists recommend waiting 48 hours before taking Inza as it may slow down healing. If you're unsure speak to a pharmacist.
  • Inza is typically used for period pain or toothache. Some people find Inza better than paracetamol for back pain.
  • Always take Inza tablets and capsules with food or a drink of milk to reduce the chance of an upset stomach. Do not take it on an empty stomach.
  • If you're taking tablets, take the lowest dose for the shortest time. Do not use it for more than 10 days unless you've spoken to your doctor. Do not use the gel, mousse or spray for more than 2 weeks without talking to your doctor.
  • Inza is called by different brand names, including Nurofen, Brufen and Calprofen (syrup). Inza gel can be called Fenbid, Ibugel and Ibuleve.

Which drugs or supplements interact with Inza?

Inza is associated with several suspected or probable interactions that can affect the action of other drugs.

  • Inza may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
  • Inza may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
  • When Inza is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
  • Inza increases the negative effect of cyclosporine on kidney function.
  • Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid Inza because Inza also thins the blood, and excessive blood thinning may lead to bleeding.
  • If aspirin is taken with Inza there may be an increased risk for developing an ulcer.
  • Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking Inza or other NSAIDs.
  • Combining SSRIs or selective serotonin reuptake inhibitors (for example, fluoxetine , citalopram , paroxetine [Paxil, Paxil CR, Pexeva) with NSAIDs may increase the likelihood of upper gastrointestinal bleeding.

Important

If you get a headache, vomit or feel sleepy after accidentally swallowing Inza gel, contact a doctor or 111 straight away.

Urgent advice: Call your doctor straight away if you've taken more than the maximum dose of Inza

If you go to a hospital accident and emergency (A&E) department, do not drive yourself – get someone else to drive you or call for an ambulance.

Take the Inza packet, or the leaflet inside it, plus any remaining medicine with you.


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