Central nervous system toxicity
If people take dosages greater than 400 mg/kg, they may experience central nervous system depression . This can cause loss of consciousness and coma.
Children may experience seizures and decreased consciousness from a massive overdose. Some children may even stop breathing.
Emergency doctors can reverse the central nervous system toxicities that occur due to an Dolocyl overdose.
Compared with NSAIDs such as diclofenac, mefenamic acid, and naproxen, Dolocyl overdoses have links with lower rates of central nervous system toxicities.
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction to Dolocyl.
Data suggest that Dolocyl may confer an increased risk of thrombotic and congestive heart failure (CHF) events relative to lumiracoxib among aspirin users at high cardiovascular risk. The study indicates that naproxen may be associated with lower risk relative to lumiracoxib among non-aspirin users.
The kidneys filter harmful substances from the body, including alcohol. The more alcohol that a person drinks, the harder the kidneys have to work.
Dolocyl and other NSAIDs affect kidney function because they stop the production of an enzyme in the kidneys called cyclooxygenase (COX). By limiting the production of COX, Dolocyl lowers inflammation and pain. However, this also changes how well the kidneys can do their job as filters, at least temporarily.
Alcohol puts additional strain on the kidneys. The National Kidney Foundation say that regular heavy drinking doubles the risk of a person developing chronic kidney disease.
Although the risk of kidney problems is low in healthy people who only occasionally take Dolocyl, the drug can be dangerous for people who already have reduced kidney function.
People who have a history of kidney problems should ask a doctor before taking Dolocyl with alcohol.
The recommended dosage for adults is one or two 200 milligram (mg) tablets every four to six hours. Adults should not exceed 800 mg at once or 3,200 mg per day.
Adults over the age of 60 should take as little Dolocyl as possible to manage their symptoms. Older adults have a higher risk of kidney and gastrointestinal side effects.
5. How to use Dolocyl gel, mousse or spray
The amount of Dolocyl you put on your skin depends on the product you're using – check the package leaflet carefully for how much to use.
Gently massage the Dolocyl into the painful area 3 or 4 times a day. Leave at least 4 hours between applications, and do not put it on more than 4 times in 24 hours.
Never use Dolocyl gel, mousse or spray on your eyes, mouth, lips, nose or genital area. Do not put it on sore or broken skin. Do not put plasters or dressings over skin you've applied Dolocyl to.
What if I accidentally swallow the gel?
If you swallow Dolocyl gel or mousse by accident, you may get symptoms including:
- being sick (vomiting)
- feeling sleepy