Cloxib capsules

Cloxib

  • Active Ingredient: Celecoxib
  • 200 mg, 100 mg
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What is Cloxib?

The active ingredient of Cloxib brand is celecoxib. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). Celecoxib works by reducing hormones that cause inflammation and pain in the body.

Used for

Cloxib is used to treat diseases such as: Ankylosing Spondylitis, Familial Adenomatous Polyposis, Fibromatosis, Juvenile Rheumatoid Arthritis, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Spondyloarthritis.

Side Effect

Possible side effects of Cloxib include: Continuing thirst; high blood pressure; troubled breathing; bleeding after defecation; bloating; buzzing or ringing noise in the ears; swelling of the face, fingers, feet, or lower legs.

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What are the side effects of Cloxib?

The most common side effects of Cloxib include:

Other and more serious side effects of Cloxib include:

Cloxib, like other NSAIDs may cause serious stomach and intestinal ulcers that may occur at any time during treatment. Cloxib does not interfere with the function of the blood platelets and, as a result, does not reduce clotting and lead to increased bleeding time like other NSAIDs.

Allergic reactions can occur with Cloxib. Individuals who have developed allergic reactions (rash, itching, difficulty breathing) from sulfonamides (for example, sulfamethoxazole and trimethoprim ), aspirin or other NSAIDs may experience an allergic reaction to Cloxib and should not take Cloxib.

NSAIDs (except for low-dose aspirin) may increase the risk of heart attacks, stroke, and related conditions, which can be fatal. This risk may increase with duration of use and in patients who have underlying risk factors for heart and blood vessel conditions. NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.

NSAIDs cause an increased risk of serious, even fatal, stomach and intestinal adverse reactions such as bleeding, ulcers, and perforation of the stomach or intestines. These events can occur at any time during treatment and without warning symptoms. Elderly patients are at greater risk for these types of reactions.

Q: Do you recommend Celebrex for mild arthritis?

A: The treatment of osteoarthritis typically follows a stepwise approach, and mild arthritis may not require drug treatment. Initially, doctors recommend that patients rest and avoid activities that cause pain, exercise to increase the strength of muscles around the affected joints, and lose weight to decrease pressure on the joints. If medication becomes necessary, it is best to start with those that have the least side effects. The first treatment is usually acetaminophen (Tylenol), which reduces pain, but does not affect inflammation. It is generally well tolerated, but taking more than recommended or having more than three alcoholic drinks per day can increase the risk of liver damage. The next treatments are nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen and naproxen. Some of these drugs are available over the counter without a prescription. They can cause stomach upset, so it is recommended that they be taken with food. Both acetaminophen and NSAIDs can interfere with blood thinners, so it is important to check with your doctor before taking these medications. Celebrex (Cloxib; //www.everydayhealth.com/drugs/celebrex) is a prescription NSAID that is also called a cyclooxygenase-2 inhibitor or COX-2 inhibitor. It causes less stomach upset than other NSAIDs; however, Celebrex and other COX-2 inhibitors may cause kidney damage or increase the risk of heart attack and stroke. COX-2 inhibitors should be taken only at the lowest dose needed to relieve your pain. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

DRUG INTERACTIONS

See Table 3 for clinically significant drug interactions with Cloxib.

Table 3: Clinically Significant Drug Interactions with CloxibDrugs That Interfere with HemostasisClinical Impact:

  • Cloxib and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of Cloxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.
  • Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.

Dictionary Entries near Cloxib

Cite this Entry

“Cloxib.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Cloxib. Accessed 27 December 2019.

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What Are Side Effects Associated with Using Cloxib?

Side effects of Cloxib include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Is Celebrex (Cloxib)?

Celebrex is the brand name for the prescription pain reliever Cloxib, the drug's active ingredient. Doctors prescribe Celebrex to treat pain, swelling, and stiffness of arthritis and some other conditions.

Celebrex is a non-steroidal anti-inflammatory drug, often referred to simply as an NSAID. NSAIDs block swelling, pain, and fever. Celebrex works by stopping the production of COX-2, a natural substance in the body that causes pain and inflammation. Celebrex is an NSAID and a COX-2 inhibitor.

The Food and Drug Administration (FDA) approved Cloxib in 1998 for the drug company G.D. Searle under the brand name Celebrex. In May 2014, the FDA approved the generic version of Cloxib.

The FDA has approved Celebrex to treat:

  • Osteoarthritis (the type of arthritis that results from wear and tear)
  • Rheumatoid arthritis (the inflammatory type of arthritis)
  • Rheumatoid arthritis in children older than 2
  • Ankylosing spondylitis (inflammatory arthritis of the spine)
  • Short-term pain caused by injury
  • Pain associated with menstrual periods
  • Polyps that grow in the colon and rectum in people with a condition called familial adenomatous polyposis.

Also, a study in the May 2014 issue of the journal Human Psychopharmacology suggested that Cloxib holds promise as an add-on treatment for people with depression. The researchers noted, though, that more study needs to be done to determine its safety and effectiveness long-term.

COMMON BRAND(S): Celebrex

GENERIC NAME(S): Cloxib

OTHER NAME(S): Cloxib Capsule

Nonsteroidal anti-inflammatory drugs (including Cloxib) may rarely increase the risk of a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop taking Cloxib and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.

This medication is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. The pain and swelling relief provided by this medication helps you perform more of your normal daily activities.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

This drug works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.

Cloxib had no effect on male or female fertility or male reproductive function in rats at oral doses up to 600 mg/kg/day (approximately 11times human exposure at 200 mg twice daily based on the AUC0-24). At ≥50 mg/kg/day (approximately 6-times human exposure based on the AUC0-24 at 200 mg twice daily) there was increased preimplantation loss.

Drug Interaction Studies

In vitro studies indicate that Cloxib is not an inhibitor of cytochrome P450 2C9, 2C19 or 3A4.

In vivo studies have shown the following:

Gastrointestinal Bleeding, Ulceration, And Perforation

NSAIDs, including Cloxib cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with CELEBREX. Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3-6 months, and in about 2%-4% of patients treated for one year. However, even short-term NSAID therapy is not without risk.

Hypersensitivity

Frequency not reported: Hypersensitivity

Hypersensitivity was reported in 0.1% to 1.9% of patients taking Cloxib 100 to 200 mg twice a day or 200 mg once a day.


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