Xepin capsules


  • Active Ingredient: Doxepin
  • 75 mg, 25 mg, 10 mg
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What is Xepin?

The active ingredient of Xepin brand is doxepin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Xepin is used to treat diseases such as: Anxiety, Depression, Insomnia, Irritable Bowel Syndrome, Major Depressive Disorder, Reflex Sympathetic Dystrophy Syndrome, Urticaria.

Side Effect

Possible side effects of Xepin include: fever; rapid weight gain; dark urine; unexplained weight loss; loss of balance control; hair loss or thinning of the hair; increased sensitivity of the skin to sunlight; weight gain.

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How it works

Xepin belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t known exactly how Xepin works to treat depression or anxiety. It may block your brain from reabsorbing norepinephrine, a chemical messenger that affects your mood. This action increases the levels of norepinephrine in your body, which helps improve your mood.

Xepin oral capsule may cause drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness after taking this drug until you know how it affects you.

This drug can also cause other side effects.


  • In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (under 24 years) taking antidepressants for major depressive disorders and other psychiatric illnesses
  • This increase was not seen in patients over 24 years; a slight decrease in suicidal thinking was seen in adults over 65 years
  • In children and young adults, risks must be weighed against the benefits of taking antidepressants
  • Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial 1-2 months of therapy and dosage adjustments
  • The patient's family should communicate any abrupt changes in behavior to the healthcare provider
  • Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy
  • This drug is not approved for use in pediatric patients
  • This medication contains Xepin
  • Do not take Silenor if you are allergic to Xepin or any ingredients contained in this drug
  • Keep out of reach of children
  • In case of overdose, get medical help or contact a Poison Control Center immediately

Rated Xepin (Silenor) for Insomnia Report

i was prescribed Xepin for my sleep disorder i only take 30mg every night, it works really well, i actually still wake up but not as often when i wasn't on anything, but i am happy with the results, i can handle 2 wake-up per night compared to 5-6 wake ups before taking Xepin, plus i don't have the nightmares related to my sleep disorder which is a plus.

Dosing Modifications

Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia

Enter a drug name and Xepin

Rated Xepin (Silenor) for Anxiety Report

I had severe depression and anxiety. My doctor tried thirteen different medications, and finally, this one worked. Problem, within ten minute of doing ANY kind of exertion, I am bathed in sweat. It is horrible. I've tried to quit this medication, but my anxiety is so bad, I just can't do it. It is truly horrible sweating all day.

Dosage for depression

Adult dosage (ages 18 to 64 years)

  • Typical starting dosage: 75 mg per day. Your doctor may tell you to take the entire dose at once, or divide it into smaller doses throughout the day.
  • Dosage adjustments: Your doctor will adjust your dosage depending on how your body responds to the drug. The usual dosage range is 75 to 150 mg per day. For severe depression, your doctor may increase your dosage to 300 mg per day. For very mild depression, dosage as low as 25 to 50 mg per day may be used.
  • Maximum dosage: 300 mg per day. If given once daily, the maximum dosage is 150 mg per day, which may be given at bedtime.

Child dosage (ages 0 to 17 years)

It isn’t known if Xepin is safe and effective for children younger than 18 years.

Senior dosage (ages 65 years and older)

The liver and kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lower dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.


Xepin is recommended for the treatment of:

  • Psychoneurotic patients with depression and/or anxiety.
  • Depression and/or anxiety associated with alcoholism (not to be taken concomitantly with alcohol).
  • Depression and/or anxiety associated with organic disease (the possibility of drug interaction should be considered if the patient is receiving other drugs concomitantly).
  • Psychotic depressive disorders with associated anxiety including involutional depression and manic-depressive disorders.

The target symptoms of psychoneurosis that respond particularly well to Xepin include anxiety, tension, depression, somatic symptoms and concerns, sleep disturbances, guilt, lack of energy, fear, apprehension and worry.

Clinical experience has shown that Xepin is safe and well tolerated even in the elderly patient. Owing to lack of clinical experience in the pediatric population, Xepin is not recommended for use in pediatric patients under 12 years of age

Xepin Dosage

The usual dose of Xepin is 75 to 300 milligrams (mg) daily, administered at bedtime or in three divided doses.

The average daily dose is 150 mg daily. Optimal improvement in depressive symptoms is seen after two to three weeks; anti-anxiety effects occur much sooner.

Xepin comes as a capsule, a tablet, or concentrate (liquid) to take by mouth.

It's usually taken one to three times a day and may be taken with or without food.

Try to take Xepin at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take Xepin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Xepin concentrate (oral liquid) comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper.

Dilute the concentrate in four ounces (120 mL) of water; whole or skim milk; or orange, grapefruit, tomato, prune, or pineapple juice just before taking it. Do not mix it with carbonated beverages (soft drinks).

It may take several weeks or longer for you to feel the full effect of Xepin. Continue to take Xepin even if you feel well.

Do not stop taking Xepin without talking to your doctor. Your doctor will probably want to decrease your dose gradually.

Xepin - Clinical Pharmacology

The mechanism of action of Xepin hydrochloride is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of norepinephrine by reuptake into the nerve terminals is prevented. Animal studies suggest that Xepin hydrochloride does not appreciably antagonize the antihypertensive action of guanethidine. In animal studies anticholinergic, antiserotonin and antihistamine effects on smooth muscle have been demonstrated. At higher than usual clinical doses, norepinephrine response was potentiated in animals. This effect was not demonstrated in humans.

At clinical dosages up to 150 mg per day, Xepin can be given to man concomitantly with guanethidine and related compounds without blocking the antihypertensive effect. At dosages above 150 mg per day blocking of the antihypertensive effect of these compounds has been reported.

Xepin is virtually devoid of euphoria as a side effect. Characteristic of this type of compound, Xepin has not been demonstrated to produce the physical tolerance or psychological dependence associated with addictive compounds.

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