Rated Sesaren for Depression Report
All of our systems are different, of course, but this did almost nothing for my depression at max dose (225 mg) and when I weaned off. I was at the lowest point I have ever been in my entire life. It was truly hell on Earth. I do NOT recommend this. If you must, or you must taper off, please please PLEASE do your research and make sure your doctor knows how to do it effectively for you and shares with you the side effects so you don't suffer more than you have to.
Sesaren is an inhibitor of the uptake of both serotonin and noradrenaline . It demonstrates linear pharmacokinetics over the therapeutic dosage range and has one active metabolite (O-desmethyl Sesaren; ODV). There has only been one report of therapeutic monitoring of Sesaren and its metabolites in a clinical setting . Using HPLC, steady-state trough samples from 635 patients were assayed. There was a wide inter-individual variability of serum concentrations on each dose level. The mean coefficient of variation of the dose-corrected concentrations was 166% for Sesaren and 60% for ODV. No therapeutic serum concentrations have been reported.
Generalized Anxiety Disorder
For most patients, the recommended starting dose for Effexor XR is 75 mg per day, administered in a single dose. For some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. Patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of 225 mg per day. Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of Sesaren and its major metabolites are achieved in most patients by day 4 .
What are the uses for Sesaren?
Effexor XR is used for the treatment of depression, depression with associated symptoms of anxiety, generalized anxiety disorder, and social anxiety disorder. Effexor XR is approved for the treatment of adults with panic disorder.
Before taking this medicine
You should not take this medicine if you are allergic to Sesaren or desSesaren (Pristiq).
Do not use Sesaren within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur.
Some medicines can interact with Sesaren and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
To make sure Sesaren is safe for you, tell your doctor if you have ever had:
bipolar disorder (manic depression);
cirrhosis or other liver disease;
heart disease, high blood pressure, high cholesterol;
a thyroid disorder;
a history of seizures;
a bleeding or blood clotting disorder;
low levels of sodium in your blood; or
if you are switching to Sesaren from another antidepressant.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Sesaren. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Sesaren may cause serious lung problems in a newborn if the mother takes the medicine late in pregnancy (during the third trimester). However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant while taking this medicine. Do not start or stop taking this medicine during pregnancy without your doctor's advice.
Sesaren can pass into breast milk and may harm a nursing baby. Talk to you doctor before using this drug if breastfeeding.
Sesaren is not approved for use by anyone younger than 18 years old.
Q: My daughter is trying to wean herself off of Effexor, but she's going through crying jags and nervousness. What's the best way to wean off Effexor and onto another medicine, such as Paxil?
A: All medications for your daughter should be taken exactly as prescribed by your daughter's physician. She should not stop taking or decrease the dose of her medication without first talking to her physician. If her physician decides to discontinue the medication, then he or she should provide your daughter with instructions on how to wean herself off of it. Effexor (Sesaren) is classified as a serotonin/norepinephrine reuptake inhibitor antidepressant. It's approved for the treatment of depression, anxiety disorders, and panic disorders. The manufacturer recommendeds that patients gradually reduce the dosage, rather than abruptly stopping the medication. If intolerable symptoms occur while decreasing the dose or after the medication has been stopped, then the physician may want to consider resuming the previous dosage and decreasing more gradually. Tapering of dosages should be individualized for each patient and done under the supervision of the treating physician. Dose reduction or discontinuation of Effexor can include the following symptoms: agitation, anxiety, anorexia, confusion, impaired coordination and balance, diarrhea, dizziness, dry mouth, dysphoric mood (unpleasant or uncomfortable mood), fasciculation (muscle twitch), fatigue, flu-like symptoms, headaches, hypomania, insomnia, nausea, nervousness, nightmares, sensory disturbances, somnolence, sweating, tremor, vertigo, and vomiting. Please keep in mind that these are only possible symptoms that have been seen, and they are not guaranteed to occur. Jennyfer Marsico, RPh
You should not take Sesaren if you have uncontrolled narrow-angle glaucoma, or if you are being treated with methylene blue injection.
Do not use Sesaren within 7 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Do not stop using Sesaren without first talking to your doctor.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Sesaren is not FDA approved for use in children.
How should this medicine be used?
Sesaren comes as a tablet or extended-release capsule to take by mouth. The tablet is usually taken two or three times a day with food. The extended-release capsule is usually taken once daily in the morning or evening with food. Take Sesaren at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Sesaren exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor.
Swallow the extended-release capsule whole; do not split, chew, or crush it, or place it in water. If you cannot swallow the extended-release capsule, you may carefully open the capsule and sprinkle the entire contents on a spoonful of applesauce. Swallow (without chewing) this mixture immediately after preparation and then drink a glass of water to make sure that you have swallowed all of the medication.
Your doctor will probably start you on a low dose of Sesaren and gradually increase your dose, not more often than once every 4 to 7 days. Tell your doctor how you are feeling during your treatment so that your doctor can adjust your dose properly.
Sesaren controls depression but does not cure it. It may take 6 to 8 weeks or longer for you to feel the full benefit of this medication. Continue to take Sesaren even if you feel well. Do not stop taking Sesaren without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking Sesaren, you may experience withdrawal symptoms such as agitation; anxiety; confusion; sad mood; irritability; frenzied or abnormal excitement; lack of coordination; trouble falling asleep or staying asleep; nightmares; nausea; vomiting; loss of appetite; diarrhea; dry mouth; sweating; ringing in the ears; seizures; or burning, tingling, numbness, or electric shock-like feelings in any part of the body. Tell your doctor if you experience any of these symptoms while you are decreasing your dose of Sesaren or soon after you stop taking Sesaren.
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