Impril tablets


  • Active Ingredient: Imipramine
  • 75 mg, 50 mg,25 mg
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What is Impril?

The active ingredient of Impril brand is imipramine. Imipramine is a tricyclic antidepressant. Imipramine affects chemicals in the brain that may be unbalanced in people with depression. Imipramine hydrochloride USP is a white to off-white, odorless, or practically odorless crystalline powder. It is freely soluble in water and in alcohol, soluble in acetone, and insoluble in ether and in benzene. Inactive Ingredients: Colloidal silicon dioxide, D & C red # 30 and # 40, D & C yellow # 6 and # 10, dicalcium phosphate, F D & C blue # 1 and # 2, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, sodium starch glycolate, titanium dioxide.

Used for

Impril is used to treat diseases such as: ADHD, Depression, Enuresis, Interstitial Cystitis, Irritable Bowel Syndrome, Night Terrors, Pain, Panic Disorder, Primary Nocturnal Enuresis, Somatoform Pain Disorder.

Side Effect

Possible side effects of Impril include: dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; shakiness and unsteady walk; uncontrolled movements, especially of the face, neck, and back; stiffness of the limbs; restlessness; difficult or troubled breathing.

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Other uses for this medicine

Impril is also used occasionally to treat eating disorders and panic disorders. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

International Brand Names

Log on to for a list of all international brand names.

Ant >Impril (Canada); Chrytemin (Japan); Daypress (Japan); Depsol (India); Depsonil (India); Ethipramine (South Africa); Fronil (Taiwan); Imidol (Japan); Imiprex (Israel); Melipramin (Czech Republic, Hungary, Poland); Melipramine (Australia); Primonil (Israel); Pryleugan (Germany); Psychoforin (Bulgaria); Sermonil (Thailand); Talpramin (Mexico); Tofranil (Argentina, Brazil, Canada, Chile, Colombia, Ecuador, Hong Kong, Indonesia, Japan, Malaysia, Mexico, Paraguay, Philippines, Taiwan, Uruguay, Venezuela); Venefon (Greece)

Other warnings

  • Monoamine ox >Research has indicated that this medication, which is a drug called an anticholinergic, can raise your risk of dementia.

Impril is a prescription drug. It come as an oral tablet and oral capsule.

Impril oral tablet is available as the brand-name drug Tofranil. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Impril oral tablet may be used as part of a combination therapy. That means you may need to take it with other medications.

Impril, synthetic drug used in the treatment of depression and enuresis (bed-wetting). Introduced into medicine in the late 1950s, Impril was the first tricyclic antidepressant, a class named for its three-ring molecular structure.

Impril works by inhibiting the reuptake of certain neurotransmitters in the brain, including acetylcholine, dopamine, norepinephrine, and serotonin. It also acts on certain other receptors, such as H1 receptors for histamine.

Impril usually is administered orally but may be given by intramuscular injection. The drug has a wide variety of side effects, which include dryness of the mouth, blurred vision, constipation, difficulty in passing urine, and cardiovascular abnormalities.

Uses of Impril Tablets:

  • It is used to treat low mood (depression).
  • It is used to help prevent bedwetting in children.
  • It may be given to you for other reasons. Talk with the doctor.

How should I take Impril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use Impril in larger or smaller amounts or for longer than recommended.

If you need surgery, tell the surgeon ahead of time that you are using Impril. You may need to stop using the medicine for a short time.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Call your doctor if your symptoms do not improve, or if they get worse.

You should not stop using Impril suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Alcohol interaction warning

Drinking alcohol can increase your risk of suicidal thoughts from Impril. If you drink alcohol, talk to your doctor.

What should I avoid while taking Impril?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with Impril. Check your food and medicine labels to be sure these products do not contain alcohol.

Impril can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid exposure to sunlight or tanning beds. Impril can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Serious Side Effects of Impril

You should stop using this medicine and call your doctor if you experience any of the following serious side effects:

  • Dizziness upon standing, fainting
  • Stroke, heart attack, or changes in heart rhythm
  • Seizures
  • Parkinson's-like signs, such as hand tremors, pill-rolling of the hands, or dragging of the feet
  • Blood abnormalities, like low white blood cell count and low levels of platelets, white blood cells, and red blood cells
  • Suic >Back to Top

Impril and Alcohol

Impramine and alcohol can both cause dry mouth, dry eyes, dizziness, and confusion.

Drinking alcohol while taking Impril may worsen these side effects, so you might want to avoid, or at least limit, alcohol while taking Impril.


Liver test abnormalities have been reported to occur in up to 20% of patients on long term therapy with Impril, but elevations are uncommonly above 3 times the upper limit of normal. The aminotransferase abnormalities are usually mild, asymptomatic and transient, reversing even with continuation of medication. Rare instances of clinically apparent acute liver injury as well as prolonged jaundice have been reported due to Impril. The onset of jaundice is usually with 1 to 8 weeks of starting therapy. The pattern of enzyme elevations varies from hepatocellular to mixed or cholestatic. Signs and symptoms of hypersensitivity (fever, rash, eosinophilia) are common, but usually not very prominent. Rapid recurrence with rechallenge is common. Autoantibody formation is rare. Rare instances of acute liver failure and death attributed to Impril have been reported.

Likelihood score: B (likely rare cause of clinically apparent liver injury).

What is the most important information I should know about Impril (Tofranil, Tofranil-PM)?

You should not take this medicine if you recently had a heart attack.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Impril can be fatal.

Overdose symptoms may include extreme drowsiness, fast or irregular heart rate, fainting, or seizure (convulsions).

Is Impril safe to take if I'm pregnant or breastfeeding?

Use of Impril during pregnancy has not been adequately evaluated.

Available evidence suggests that Impril may be excreted in breast milk and may be harmful to the infant.

Rated Impril for Panic Disorder Report

Took Impramine for almost 33 years. Going off of this day medication because of Impramine-induced hyper-pigmentation. For the last year, I have noticed dark skin under and around my eyes. Dermatologist advised me to stop this drug.

What are some other side effects of Impril Tablets?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Dry mouth.
  • Constipation.
  • Upset stomach or throwing up.
  • Not hungry.
  • Diarrhea.
  • Change in taste.
  • Stomach cramps.
  • Feeling sleepy.
  • Weight gain or loss.
  • Sweating a lot.
  • Flushing.
  • Feeling tired or weak.
  • Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

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