Doxal capsules


  • Active Ingredient: Doxepin
  • 75 mg, 25 mg, 10 mg
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What is Doxal?

The active ingredient of Doxal brand is doxepin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Doxal is used to treat diseases such as: Anxiety, Depression, Insomnia, Irritable Bowel Syndrome, Major Depressive Disorder, Reflex Sympathetic Dystrophy Syndrome, Urticaria.

Side Effect

Possible side effects of Doxal include: lethargy; fruit-like breath odor; unusual tiredness or weakness; mood or mental changes; agitation; yellow eyes or skin; blurred vision; heartburn.

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Q: What is Doxal 25 mg used for?

A: Doxal is in a group of drugs called tricyclic antidepressants. Doxal affects chemicals in the brain that may become unbalanced. Doxal is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions. Doxal may also be used for other purposes. Kristen Dore, PharmD

Other warnings

  • Drowsiness warning: You shouldn’t drive, use machinery, or do other activities that require alertness until you know how this drug affects you.
  • Dementia warning:Research has indicated that this type of medication can cause effects similar to those caused by drugs called anticholinergics. This can raise your risk of dementia.

Doxal is a prescription drug. It comes as an oral tablet, oral capsule, oral solution, and topical cream.

Doxal oral capsule doesn’t have a brand-name version. It’s only available as a generic drug. Generic drugs usually cost less than brand-name drugs.

Rated Doxal (Silenor) for Insomnia Report

I am a chronic insomniac. I have tried a lot of medications. I was given Doxal because my insomnia is anxiety related. I am a chronic worrier so I have major depression, GAD, and insomnia. I have a love/hate relationship with Doxal. I love that it is very helpful for anxiety. Doxal is as good as the benzos are for anxiety in my opinion. I love that it helps for sleep. It isn't the best sleeping med as it doesn't keep you asleep but it does a good job of helping you go to sleep. The bad side of this med are its side effects. My God does this med make me tired. My body and eyes feel tired all day. I also think that this med induced tinnitus. This med alsonmakes my nose stuffy and generates a lot of mucos in my nose. All in all I would recommend it but with just a little trepidation because of the side effects. I wish you sweet dreams and I hope this can help some people out there. Peace.


Doxal is contraindicated in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.

Doxal is contraindicated in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.

What should I do if I forget a dose?

Doxal (Silenor) should only be taken at bedtime. If you did not take Doxal (Silenor) before you went to bed and you are having trouble sleeping, you may take Doxal (Silenor) if you will be able to stay in bed for at least 7 to 8 hours afterward. Do not take a double dose of Doxal (Silenor) to make up for a missed dose.

For Healthcare Professionals

Applies to Doxal: oral capsule, oral concentrate, oral tablet


NOTE: Some of the adverse reactions noted below have not been specifically reported with Doxal use. However, due to the close pharmacological similarities among the tricyclics, the reactions should be considered when prescribing Doxal hydrochloride.

Anticholinergic Effects : Dry mouth, blurred vision, constipation, and urinary retention have been reported. If they do not subside with continued therapy, or become severe, it may be necessary to reduce the dosage.

Central Nervous System Effects : Drowsiness is the most commonly noticed side effect. This tends to disappear as therapy is continued. Other infrequently reported CNS side effects are confusion, disorientation, hallucinations, numbness, paresthesias, ataxia, extrapyramidal symptoms, seizures, tardive dyskinesia, and tremor.

Cardiovascular : Cardiovascular effects including hypotension, hypertension, and tachycardia have been reported occasionally.

Allergic : Skin rash, edema, photosensitization, and pruritus have occasionally occurred.

Hematologic : Eosinophilia has been reported in a few patients. There have been occasional reports of bone marrow depression manifesting as agranulocytosis, leukopenia, thrombocytopenia, and purpura.

Gastrointestinal : Nausea, vomiting, indigestion, taste disturbances, diarrhea, anorexia, and aphthous stomatitis have been reported. (See Anticholinergic Effects.)

Endocrine : Raised or lowered libido, testicular swelling, gynecomastia in males, enlargement of breasts and galactorrhea in the female, raising or lowering of blood sugar levels, and syndrome of inappropriate antidiuretic hormone secretion have been reported with tricyclic administration.

Other : Dizziness, tinnitus, weight gain, sweating, chills, fatigue, weakness, flushing, jaundice, alopecia, headache, exacerbation of asthma, and hyperpyrexia (in association with chlorpromazine) have been occasionally observed as adverse effects.

Withdrawal Symptoms : The possibility of development of withdrawal symptoms upon abrupt cessation of treatment after prolonged Doxal administration should be borne in mind. These are not indicative of addiction and gradual withdrawal of medication should not cause these symptoms.

Rated Doxal (Silenor) for Atopic Dermatitis Report

About 5 years ago I started itching uncontrollably all over my body (minus the bottom of my feet and palms of my hand). I went to several specialists and tried many medications. The best way to describe the itchy feeling I experienced was that it felt deep down under my skin like nerve related. None of the specialists could link my unknown itching to anything in particular. As a last ditch effort, my PCP said I could try Doxal. It was a miracle in my eyes! I had itched non-stop for over 2 years, which as you can imagine was a nightmare! It also helped me sleep like a baby. My effective dose initially to help me stop itching was 75 mg twice a day. Now I only take 50 mg at night. Oddly enough, it has never made me sleepy during the day, but helped me sleep at night. I did gain weight while taking this medication, however, I have Hashimoto's Thyroiditis/Hypothyroidism as well, so I don't have anyway of knowing if the Doxal was the cause of my weight gain. For me personally, this drug has been a life saver.

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