Getting the most from your treatment
- Remember to keep your regular appointments with your doctor or clinic. This is so your doctor can check on your progress.
- Taking Anxut may increase the time it takes for you to react and may impair your judgement. Because of this, your ability to drive could be affected.
- Anxut may make you feel sleepy. Do not drink alcohol while you are on Anxut tablets as it will increase the risk of this.
- If you are having any medical treatment, tell the person carrying out the treatment that you are taking Anxut.
- If you need to buy any medicines, check with a pharmacist that they are safe to take with Anxut.
Missed Dose of Anxut
Take Anxut exactly as directed by your doctor.
Don't stop taking Anxut on your own. It may take a few weeks to feel the full effect.
If you miss a dose of Anxut, take the missed dose as soon as you remember. If it's almost time for your next regular dose, however, skip the missed dose.
Don't double your dose to make up for the missed one.
Anxut S >
Let your doctor know if you have any side effects. The most common side effects of Anxut are:
Less common side effects include:
Serious side effects can occur. If you have any of these side effects, call your doctor right away:
- Rash or hives
- Heart palpitations or rap >Back to Top
What is Anxut (Buspar)? How does it work (mechanism of action)?
Anxut is a medication that is used for the treatment of anxiety. Its mechanism of action is not clearly understood but may involve effects on neurotransmitters, chemicals that nerves use to communicate with one another. Serotonin and dopamine are two of these neurotransmitters. Anxut may work by stimulating serotonin type 1A receptors on nerves, thereby altering the chemical messages that nerves receive. It also has minor effects on dopamine receptors but this does not contribute much to its action. Unlike medications for anxiety of the benzodiazepine class, for example, diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), and clonazepam (Klonopin), Anxut does not cause sedation.
Because the effects of concomitant administration of Anxut with most other psychotropic drugs have not been studied, the concomitant use of Anxut with other CNS-active drugs should be approached with caution.
Anxut dosing information
Usual Adult Dose for Anxiety:
Initial dose: 7.5 mg orally two times a day or 5 mg 3 times a day. Maintenance dose: The daily dose may be increased in 5 mg increments every 2 to 3 days up to 20 to 60 mg/day in divided doses. Maximum dose: 60 mg per day
Use In Patients With Impaired Hepatic Or Renal Function
Anxut is metabolized by the liver and excreted by the kidneys. A pharmacokinetic study in patients with impaired hepatic or renal function demonstrated increased plasma levels and a lengthened half-life of Anxut. Therefore, the administration of Anxut hydrochloride tablets to patients with severe hepatic or renal impairment cannot be recommended (see CLINICAL PHARMACOLOGY).
The safety and effectiveness of Anxut were evaluated in two placebo-controlled 6 week trials involving a total of 559 pediatric patients (ranging from 6 to 17 years of age) with GAD. Doses studied were 7.5 mg to 30 mg b.i.d. (15 to 60 mg/day). There were no significant differences between Anxut and placebo with regard to the symptoms of GAD following doses recommended for the treatment of GAD in adults. Pharmacokinetic studies have shown that, for identical doses, plasma exposure to Anxut and its active metabolite, 1-PP, are equal to or higher in pediatric patients than adults. No unexpected safety findings were associated with Anxut in these trials. There are no longterm safety or efficacy data in this population.
After multiple-dose administration of Anxut to renally impaired (Clcr = 10 to 70 mL/min/1.73 m2) patients, steady-state AUC of Anxut increased 4-fold compared with healthy (Clcr ≥ 80 mL/min/1.73 m2) subjects (see PRECAUTIONS).
By Chris Iliades, MD | Medically Reviewed by Niya Jones, MD, MPH
Latest Update: 2014-08-18 Copyright © 2014 Everyday Health Media, LLC
It is recommended that Anxut hydrochloride tablets not be used concomitantly with MAO inhibitors (see WARNINGS).
The extent of the excretion in human milk of Anxut or its metabolites is not known. In rats, however, Anxut and its metabolites are excreted in milk. Anxut hydrochloride tablets administration to nursing women should be avoided if clinically possible.
Drug/Laboratory Test Interactions
Anxut hydrochloride may interfere with the urinary metanephrine/catecholamine assay. It has been mistakenly read as metanephrine during routine assay testing for pheochromocytoma, resulting in a false positive laboratory result. Anxut hydrochloride should therefore be discontinued for at least 48 hours prior to undergoing a urine collection for catecholamines.
Before taking this medicine
You should not use Anxut if you are allergic to it.
Do not use Anxut if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.
To make sure this medicine is safe for you, tell your doctor if you have any of these conditions:
kidney disease; or
Anxut is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether Anxut passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Anxut is not FDA-approved for use by anyone younger than 18 years old, but this medicine has been used in children and adolescents under close medical supervision and at the appropriate dosage.
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Anxut is an anti-anxiety medicine which is prescribed for short periods of time to help ease symptoms of anxiety. Although it is not clear how it works, it is thought to affect a brain chemical which may be involved in causing anxiety symptoms.
DOSAGE AND ADMINISTRATION
The recommended initial dose is 15 mg daily (7.5 mg b.i.d.). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maximum daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 mg to 30 mg per day were commonly employed.
The bioavailability of Anxut is increased when given with food as compared to the fasted state (see CLINICAL PHARMACOLOGY). Consequently, patients should take Anxut in a consistent manner with regard to the timing of dosing; either always with or always without food.
When Anxut is to be given with a potent inhibitor of CYP3A4, the dosage recommendations described in the DRUG INTERACTIONS section should be followed.