How should I keep Zithrocin (Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax) stored?
The most common side effects of Zithrocin are:
Other possible side effects of Zithrocin include:
Possible serious side effects of Zithrocin include:
Antibiotics can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile, which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting Zithrocin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.
Before taking Zithrocin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Zithrocin it is important that your doctor or pharmacist knows:
- If you are pregnant or breast-feeding.
- If you have any problems with the way your liver works or the way your k >
Plasma concentrations of Zithrocin following single 500 mg oral and IV doses declined in a polyphasic pattern resulting in an average terminal half-life of 68 hr. Biliary excretion of Zithrocin, predominantly as unchanged drug, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine.
Q: What does Zithromax look like?
A: Brand name Zithromax (Zithrocin) 250 mg tablets are pink, oval shaped tablets with PFIZER imprinted on one side and 306 on the other. Brand name Zithromax 500 mg tablets are pink, oval shaped tablets with Pfizer imprinted on one side and ZTM500 on the other. Brand name Zithromax 600 mg tablets are white, oval shaped tablets with PFIZER imprinted on one side and 308 on the other. Please check with the pharmacy where the medication was dispensed for appropriate identification. Zithromax is categorized as a macrolide antibiotic. Zithromax fights bacteria in your body. Zithromax is indicated to treat several bacterial infections. Some of the possible side effects associated with Zithromax treatment include mild nausea, vomiting, diarrhea, constipation, stomach pain or upset, headache, dizziness, feeling tired, difficulty sleeping, nervousness, mild itching or skin rash, vaginal itching or discharge, decreased sense of taste or smell and ringing in your ears. Zithromax may be taken with or without food. If Zithromax upsets your stomach, take it with food. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-01-14 Copyright © 2014 Everyday Health Media, LLC
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In clinical trials, most of the reported adverse reactions were mild to moderate in severity and were reversible upon discontinuation of the drug. Approximately 0.7% of the patients from the multiple-dose clinical trials discontinued ZITHROMAX (Zithrocin) therapy because of treatment-related adverse reactions. Serious adverse reactions included angioedema and cholestatic jaundice. Most of the adverse reactions leading to discontinuation were related to the gastrointestinal tract, e.g., nausea, vomiting, diarrhea, or abdominal pain.
Prolonged cardiac repolarization and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen with treatment with macrolides, including Zithrocin. Cases of torsades de pointes have been spontaneously reported during postmarketing surveillance in patients receiving Zithrocin. Providers should consider the risk of QT prolongation which can be fatal when weighing the risks and benefits of Zithrocin for at-risk groups including:
- patients with known prolongation of the QT interval, a history of torsades de pointes, congenitallong QT syndrome, bradyarrhythmias or uncompensated heart failure
- patients on drugs known to prolong the QT interval
- patients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents.
Elderly patients may be more susceptible to drug-associated effects on the QT interval.
Q: Can Zithrocin cause itching? My pills are white and have an imprint of "GGD6". Am I taking the right medication?
A: Zithrocin (Zithromax) is in a group of drugs called macrolide antibiotics, and the pills you have that are white with the imprint of GGD6 are identified as Zithrocin by the manufacturer Sandoz. The pink and blue tablets are from a different manufacturer. Zithrocin is used to treat many different bacterial infections including sinusitis, ear infections, pneumonia, and urinary tract infections. The most common side effects associated with Zithrocin include mild nausea, vomiting, diarrhea, constipation; stomach pain or upset; dizziness, tired feeling, or headache; nervous feeling, sleep problems (insomnia); vaginal itching or discharge; mild itching or skin rash; ringing in your ears, problems with hearing; or decreased sense of taste or smell. In addition, antibiotics can produce hypersensitivity reactions in people, which may indicate an allergy to the medicine. It is important to contact your doctor when you experience a side effect, especially if it gets worse or more symptoms appear. Michelle McDermott, RPh, PharmD
As these patients with advanced HIV disease were taking multiple concomitant medications and experienced a variety of intercurrent illnesses, it was often difficult to attribute adverse reactions to study medication. Overall, the nature of adverse reactions seen on the weekly dosage regimen of Zithrocin over a period of approximately one year in patients with advanced HIV disease were similar to that previously reported for shorter course therapies.
INCIDENCE OF ONE OR MORE TREATMENT-RELATED a ADVERSE REACTIONS b IN HIV INFECTED PATIENTS RECEIVING PROPHYLAXIS FOR DISSEMINATED MAC OVER APPROXIMATELY 1 YEAR
Adverse reactions related to the gastrointestinal tract were seen more frequently in patients receiving Zithrocin than in those receiving placebo or rifabutin. In Study 174, 86% of diarrheal episodes were mild to moderate in nature with discontinuation of therapy for this reason occurring in only 9/233 (3.8%) of patients.
Pregnancy Category B: Reproduction studies have been performed in rats and mice at doses up to moderately maternally toxic dose levels (i.e., 200 mg/kg/day). These daily doses in rats and mice, based on body surface area, are estimated to be 3.2 and 1.6 times, respectively, an adult daily dose of 600 mg. In the animal studies, no evidence of harm to the fetus due to Zithrocin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Zithrocin should be used during pregnancy only if clearly needed.
Co-administration of nelfinavir at steady-state with a single oral dose of Zithrocin resulted in increased Zithrocin serum concentrations. Although a dose adjustment of Zithrocin is not recommended when administered in combination with nelfinavir, close monitoring for known adverse reactions of Zithrocin, such as liver enzyme abnormalities and hearing impairment, is warranted.
Where can I get more information?
Your pharmacist can provide more information about Zithrocin.