Zinoxime tablets

Zinoxime

  • Active Ingredient: Cefuroxime
  • 500 mg, 250 mg
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What is Zinoxime?

The active ingredient of Zinoxime brand is cefuroxime. Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Used for

Zinoxime is used to treat diseases such as: Bacterial Infection, Bladder Infection, Bone infection, Bronchitis, Epiglottitis, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Impetigo, Joint Infection, Kidney Infections, Lyme Disease, Meningitis, Otitis Media, Peritonitis, Pneumonia, Sepsis, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, Strep Throat, Surgical Prophylaxis, Tonsillitis/Pharyngitis, Upper Respiratory Tract Infection, Urinary Tract Infection, Wound Infection.

Side Effect

Possible side effects of Zinoxime include: sleepiness or unusual drowsiness; clay-colored stools; painful or difficult urination; red or black, tarry stools; Back, leg, or stomach pains; change in taste; flushing or redness of the skin; muscle pain or stiffness.

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Storage And Handling

CEFTIN tablets, 250 mg of Zinoxime (as Zinoxime axetil), are white, capsule-shaped, film-coated tablets engraved with “GX ES7” on one side and blank on the other side as follows: 20 Tablets/Bottle NDC 0173-0387-00

CEFTIN tablets, 500 mg of Zinoxime (as Zinoxime axetil), are white, capsule-shaped, film-coated tablets engraved with “GX EG2” on one side and blank on the other side as follows: 20 Tablets/Bottle NDC 0173-0394-00

Store the tablets between 15° and 30°C (59° and 86°F). Replace cap securely after each opening.

CEFTIN for oral suspension is provided as dry, white to off-white, tutti-frutti-flavored powder. When reconstituted as directed, the suspension provides the equivalent of 125 mg or 250 mg of Zinoxime (as Zinoxime axetil) per 5 mL. It is supplied in amber glass bottles as follows:

What are the side effects of Zinoxime?

Zinoxime is generally well tolerated, and side effects are usually transient. Commonly reported side effects are:

Other important side effects include:

Since Zinoxime is chemically related to penicillin, patients allergic to penicillin may develop an allergic reaction (sometimes even anaphylaxis) to Zinoxime. Zinoxime like other antibiotics can alter the colon's normal bacteria, leading to overgrowth of a bacterium called Clostridium difficile. Overgrowth of this bacterium leads to the release of toxins that contribute to the development of Clostridium difficile-associated diarrhea, which may range in severity from mild diarrhea to fatal pseudomembranous colitis.

Zinoxime axetil is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Zinoxime axetil has activity in the presence of some β-lactamases, both penicillinases and cephalosporinases, of gram-negative and gram-positive bacteria.

How should I take Zinoxime (Ceftin)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Zinoxime tablets with or without meals. Do not crush the tablet or it could have an unpleasant bitter taste.

Zinoxime oral suspension (liquid) must be taken with food.

Shake the liquid well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

If you switch from using the tablet form to using the liquid form of Zinoxime, you may not need to use the same exact dosage in number of milligrams. This medicine may not be as effective unless you use the exact form and strength your doctor has prescribed.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Zinoxime will not treat a viral infection such as the flu or a common cold.

This medicine can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Zinoxime.

Store Zinoxime tablets at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Store Zinoxime liquid in the refrigerator. Do not allow it to freeze. Throw away any unused Zinoxime liquid that is older than 10 days.

Drug Levels

Maternal Levels. A single intravenous dose of 750 mg of Zinoxime was given to 5 women. The average peak Zinoxime level in milk was 0.37 mg/L 3 hours after the dose. Individual peak levels of 0.33 to 0.5 mg/L occurred 2 to 4 hours after the dose.

A single intramuscular injection of 750 mg of Zinoxime was given to 8 women with endometritis. Milk Zinoxime levels increased from 0.34 mg/L at 30 minutes after the injection to 1.45 mg/L at 8 hours after the injection.

After Zinoxime 750 mg three times daily intramuscularly, peak milk levels averaging 1.2 mg/L occurred 6 hours after the dose. Zinoxime was detectable at a concentration of 0.36 mg/L 30 minutes after the dose, and by 8 hours the milk level had decreased to 1.06 mg/L.

One mother received Zinoxime axetil 500 mg orally three times daily for acute mastitis of the left breast following incision and drainage of the lesion. Milk samples were taken from each breast 30 minutes after the dose on day 1 of therapy. The concentration of Zinoxime in the unaffected breast was 90 mcg/L and the concentration in the breast treated for mastitis was 590 mcg/L. On day 2 of therapy, milk samples from the right and left breast were taken 90 minutes after the dose were 57 and 59 mcg/L, respectively. On day 3, milk samples obtained 90 minutes after the dose contained 27 mcg/L in the unaffected breast and 1.07 mg/L in the affected breast.

Two women were who had been receiving intravenous Zinoxime 750 mg 3 times daily for 2 days following cesarean section donated milk samples 1 hours after the dose. Milk concentrations were 0.34 and 0.39 mg/L.

Infant Levels. Relevant published information was not found as of the revision date.

What is the most important information I should know about Zinoxime (Ceftin)?

You should not use this medicine if you are allergic to Zinoxime or to similar antibiotics, such as cefdinir (Omnicef), cefprozil (Cefzil), cephalexin (Keflex), and others.


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